Application value of umbilical cord blood inflammatory markers in neonatal pulmonary infectious diseases

Hui LIU; Wei CHENG; Li WANG

doi:10.16016/j.1000-5404.202001021

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Application value of umbilical cord blood inflammatory markers in neonatal pulmonary infectious diseases

更新时间：2026-01-09

- Application value of umbilical cord blood inflammatory markers in neonatal pulmonary infectious diseases
- Journal of Third Military Medical University Vol. 42, Issue 11, Pages: 1124-1129(2020)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the Project of Technology Innovation and Application Demonstration in Social Livelihood of Chongqing(CSTC2018jscx-msybX0054)
- DOI：10.16016/j.1000-5404.202001021
  CLC：
- Received：03 January 2020，
  
  Published：15 June 2020
- 稿件说明：
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Hui LIU, Wei CHENG, Li WANG. Application value of umbilical cord blood inflammatory markers in neonatal pulmonary infectious diseases[J]. Journal of Third Military Medical University, 2020, 42(11): 1124-1129.
DOI：

Hui LIU, Wei CHENG, Li WANG. Application value of umbilical cord blood inflammatory markers in neonatal pulmonary infectious diseases[J]. Journal of Third Military Medical University, 2020, 42(11): 1124-1129. DOI： 10.16016/j.1000-5404.202001021.

摘要

Abstract

Objective

To investigate the application value of umbilical cord blood inflammatory markers in neonatal pulmonary infectious diseases.

Methods

Samples of umbilical cord blood from the women with gestational age between 34 weeks and 42 weeks during delivery in our hospital were enrolled from Jane 2018 to September 2019. Thirty-nine samples were assigned into case group

with the neonates with high risk signs of maternal infection

respiratory distress and respiratory support within 24 h after birth

and another 40 samples from normal neonates without any signs of maternal infection and being healthy after birth were assigned into control group (40 cases). All blood samples were tested for the levels of neutrophils CD64 and inflammatory factors

including IL-2R

IL-8

IL-10

TNF-α and IL-6. The case group was further divided into pulmonary edema subgroup and non-pulmonary edema subgroup

and acute respiratory distress syndrome (ARDS) subgroup and non-ARDS subgroup. The levels of inflammatory markers were analyzed and compared between the groups and subgroups. Receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC) were used to assess their values.

Results

The levels of IL-2R

IL-8

IL-10

TNF-α and IL-6 were significantly higher in the case group than the control group (

0.05)

but no obvious difference was seen in the level of CD64 between them (

0.05). The levels of TNF-α and IL-6 in the pulmonary edema subgroup were notably higher than those in the non-pulmonary edema subgroup (

0.05). The ARDS subgroup had statistically higher TNF-α and IL-2R levels when compared with the non-ARDS subgroup (

0.05).

Conclusion

For the near-term and full-term neonates with high risk of intrauterine infection

inflammatory markers in the umbilical cord blood are expected to be early warning markers of neonatal pulmonary infectious diseases. TNF-α and IL-6 have clinical value in the early estimation of pulmonary edema

and TNF-α and IL-2R have the potential for ARDS.

关键词

Keywords

references

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