Feasibility of blood gas analysis device for injury assessment following limb fracture in rabbits: simulation of the combat casualty evacuation scenario

Yao JIANG; Xiaolin ZHOU; Xin ZHONG; Zhao YE; Renqing JIANG; Xuan YU; Yungui WANG; Zhaowen ZONG

doi:10.16016/j.1000-5404.201912263

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Feasibility of blood gas analysis device for injury assessment following limb fracture in rabbits: simulation of the combat casualty evacuation scenario

更新时间：2026-01-09

- Feasibility of blood gas analysis device for injury assessment following limb fracture in rabbits: simulation of the combat casualty evacuation scenario
- Journal of Third Military Medical University Vol. 42, Issue 8, Pages: 747-751(2020)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the Clinical Technical Innovation Training Project of Army Medical University in 2019(CX2019JS107);the Project of Clinical Major Innovation technology of Xinqiao Hospital(2018JSLC0023)
- DOI：10.16016/j.1000-5404.201912263
  CLC：
- Received：27 December 2019，
  
  Published：30 April 2020
- 稿件说明：
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Yao JIANG, Xiaolin ZHOU, Xin ZHONG, et al. Feasibility of blood gas analysis device for injury assessment following limb fracture in rabbits: simulation of the combat casualty evacuation scenario[J]. Journal of Third Military Medical University, 2020, 42(8): 747-751.
DOI：

Yao JIANG, Xiaolin ZHOU, Xin ZHONG, et al. Feasibility of blood gas analysis device for injury assessment following limb fracture in rabbits: simulation of the combat casualty evacuation scenario[J]. Journal of Third Military Medical University, 2020, 42(8): 747-751. DOI： 10.16016/j.1000-5404.201912263.

摘要

Abstract

Objective

To study the value of point-of-care blood gas analyzer for evaluation of blood loss and the effect of resuscitation following limb fracture in rabbits and explore the feasibility of using the device for injury assessment and guiding resuscitation measures in the scenario of evacuation of combat casualties with limb fractures.

Methods

Fifteen rabbits were randomized equally into simple fracture group

fracture with massive hemorrhage group

and fracture with hemorrhage resuscitation group (

=5). Models of tibial fracture were established in all the rabbits by cutting the middle part of tibia with a circular saw. Twenty percent of the total blood volume was extracted from the femoral artery in the fracture with hemorrhage group

and in the resuscitation group

the extracted blood was transfused back 30 min after the injury. The level of lactate

base excess value and pH value of the rabbits were measured at 0 and 30 min

and 1 and 2 h using a point-of-care blood gas analyzer.

Results

The point-of-care blood gas analyzer detected significant changes in base excess value in the rabbits as early as 30 min after tibial fracture with massive hemorrhage

as compared with 2 h following a simple tibial fracture; significant changes in base excess value occurred 2 h after resuscitation for fracture with massive hemorrhage. Significant changes in lactate level were observed 30 min after fracture with massive hemorrhage and 2 h after simple fracture

but not found following resuscitation in the case of fracture with massive hemorrhage. pH value did not show significant variations after the injuries.

Conclusion

Lactate level and base excess value measured by point-of-care blood gas analysis can be indicative of the severity of limb fracture and blood loss in the course of patient evacuation

and the base excess value following resuscitation before admission can reflect the effect of injury control and resuscitation.

关键词

Keywords

references

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