Effect of different durations of post-resuscitation oxygen ventilation on neurological function in rats after cardiac arrest

Yiming1 SHEN; Qiuhong2 WANG; Jianjie WANG; Yongqin LI; Dan ZHANG

doi:10.16016/j.1000-5404.201912232

您当前的位置：

首页 >

文章列表页 >

Effect of different durations of post-resuscitation oxygen ventilation on neurological function in rats after cardiac arrest

更新时间：2026-01-09

- Effect of different durations of post-resuscitation oxygen ventilation on neurological function in rats after cardiac arrest
- Journal of Third Military Medical University Vol. 42, Issue 11, Pages: 1078-1085(2020)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the Key Project of Chongqing Municipal Committee of Health and Family Planning(2016ZDXM001);the General Program of National Natural Science Foundation of China(81372102)
- DOI：10.16016/j.1000-5404.201912232
  CLC：
- Received：24 December 2019，
  
  Published：15 June 2020
- 稿件说明：
移动端阅览
Yiming1 SHEN, Qiuhong2 WANG, Jianjie WANG, et al. Effect of different durations of post-resuscitation oxygen ventilation on neurological function in rats after cardiac arrest[J]. Journal of Third Military Medical University, 2020, 42(11): 1078-1085.
DOI：

Yiming1 SHEN, Qiuhong2 WANG, Jianjie WANG, et al. Effect of different durations of post-resuscitation oxygen ventilation on neurological function in rats after cardiac arrest[J]. Journal of Third Military Medical University, 2020, 42(11): 1078-1085. DOI： 10.16016/j.1000-5404.201912232.

摘要

Abstract

Objective

To investigate the effect of pure oxygen ventilation under normothermia for different durations on the neurological outcome in

rat model of asphyxia cardiac arrest.

Methods

total of 32 male SD rats were treated with cardiopulmonary resuscitation 6 min after cardiac arrest induced by asphyxia. After return of spontaneous circulation (ROSC)

the rats were randomly divided into 4 groups according to the duration of ventilation of pure oxygen (8 in each group)

that is

0 min group (O

-0 min)

20 min group (O

-20 min)

60 min group (O

-60 min) and 180 min group (O

-180 min). Physiological parameters

continuous electroencephalography (EEG) waveforms

and EEG power of each band during post-resuscitation were recorded and compared among the groups. The serum contents of cardiac troponin

(cTnT) and S100 β protein were measured by enzyme-linked immunosorbent assay (ELISA) at the basic state and 6

after resuscitation. The neurological deficit score (NDS)

96-hour survival rate and histological changes of hippocampus were compared in the groups.

Results

After resuscitation

the mean arterial pressure (MAP) was decreased significantly

and the left ventricular ejection fraction (LVEF) was decreased first and then increased in the 4 groups. The 2 indicators were significantly higher in the O

-180 min group than the O

-0 min group (

0.05). With the increase of oxygen ventilation

shorter EEG recovery time and gradually stronger EEG power spectrum energy were observed in all the groups. The O

-180 min group had significantly shorter time and stronger energy than the O

-0 min group (

0.05). At 6

after resuscitation

cerebral and myocardial injuries were obviously milder in the O

-180 min group than the O

-0 min group (S100β

0.01; cTnT

0.05). NDS

survival rate and hippocampal injury were significantly improved in the O

-180 min group when compared with the O

-0 min group.

Conclusions

In this rat model of asphyxia cardiac arrest

prolonged pure oxygen inhalation under normothermia can alleviate cerebral injury

improve neurological outcome and increase the survival rate.

关键词

Keywords

references

BERDOWSKI J BERG R A TIJSSEN J G Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies Resuscitation 2010 81 11 1479 1487 10.1016/j.resuscitation.2010.08.006 BERDOWSKI J, BERG R A, TIJSSEN J G, et al . Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies[J ] . Resuscitation, 2010, 81(11): 1479-1487. DOI:10.1016/j.resuscitation. 2010.08.006.

BOYCE L W VLIET VLIELAND T P BOSCH J High survival rate of 43% in out-of-hospital cardiac arrest patients in an optimised chain of survival Neth Heart J 2015 23 1 20 25 10.1007/s12471-014-0617-x BOYCE L W, VLIET VLIELAND T P, BOSCH J, et al . High survival rate of 43% in out-of-hospital cardiac arrest patients in an optimised chain of survival[J ] . Neth Heart J, 2015, 23(1): 20-25. DOI:10.1007/s12471-014-0617-x.

SHAO F LI C S LIANG L R Outcome of out-of-hospital cardiac arrests in Beijing, China Resuscitation 2014 85 11 1411 1417 10.1016/j.resuscitation.2014.08.008 SHAO F, LI C S, LIANG L R, et al . Outcome of out-of-hospital cardiac arrests in Beijing, China[J ] . Resuscitation, 2014, 85(11): 1411-1417. DOI:10.1016/j.resuscitation.2014.08.008.

CALLAWAY C W DONNINO M W FINK E L Part 8: post-cardiac arrest care Circulation 2015 132 18 suppl 2 S465 S482 10.1161/cir.0000000000000262 CALLAWAY C W, DONNINO M W, FINK E L, et al . Part 8: post-cardiac arrest care[J ] . Circulation, 2015, 132(18 suppl 2): S465-S482. DOI:10.1161/cir.0000000000 000262.

DELL'ANNA A M LAMANNA I VINCENT J L How much oxygen in adult cardiac arrest? Crit Care 2014 18 5 555 10.1186/s13054-014-0555-4 DELL'ANNA A M, LAMANNA I, VINCENT J L, et al . How much oxygen in adult cardiac arrest?[J ] . Crit Care, 2014, 18(5): 555. DOI:10.1186/s13054-014-0555-4.

TERAN F ABELLA B S Oxygen delivery after cardiac arrest: Adding fuel to the fire? Resuscitation 2018 128 A5 A6 10.1016/j.resuscitation.2018.05.016 TERAN F, ABELLA B S. Oxygen delivery after cardiac arrest: Adding fuel to the fire?[J]. Resuscitation, 2018, 128: A5-A6. DOI:10.1016/j.resuscitation.2018.05.016.

ROBERTS B W KILGANNON J H HUNTER B R Association between early hyperoxia exposure after resuscitation from cardiac arrest and neurological disability: prospective multicenter protocol-directed cohort study Circulation 2018 137 20 2114 2124 10.1161/CIRCULATIONAHA.117.032054 ROBERTS B W, KILGANNON J H, HUNTER B R, et al . Association between early hyperoxia exposure after resuscitation from cardiac arrest and neurological disability: prospective multicenter protocol-directed cohort study[J ] . Circulation, 2018, 137(20): 2114-2124. DOI:10.1161/CIRCULATIONAHA.117.032054.

WANG H E PRINCE D K DRENNAN I R Post-resuscitation arterial oxygen and carbon dioxide and outcomes after out-of-hospital cardiac arrest Resuscitation 2017 120 113 118 10.1016/j.resuscitation.2017.08.244 WANG H E, PRINCE D K, DRENNAN I R, et al . Post-resuscitation arterial oxygen and carbon dioxide and outcomes after out-of-hospital cardiac arrest[J ] . Resuscitation, 2017, 120: 113-118. DOI:10.1016/j.resuscitation.2017.08.244.

VARVAROUSIS D VARVAROUSI G IACOVIDOU N The pathophysiologies of asphyxial vs dysrhythmic cardiac arrest: implications for resuscitation and post-event management Am J Emerg Med 2015 33 9 1297 1304 10.1016/j.ajem.2015.06.066 VARVAROUSIS D, VARVAROUSI G, IACOVIDOU N, et al . The pathophysiologies of asphyxial vs dysrhythmic cardiac arrest: implications for resuscitation and post-event management[J ] . Am J Emerg Med, 2015, 33(9): 1297-1304. DOI:10.1016/j.ajem.2015.06.066.

中国研究型医院学会心肺复苏学专业委员会 2016中国心肺复苏专家共识中华危重病急救医学 2016 28 12 1059 1079 10.3760/cma.j.issn.2095-4352.2016.12.002 中国研究型医院学会心肺复苏学专业委员会. 2016中国心肺复苏专家共识[J].中华危重病急救医学, 2016, 28(12): 1059-1079. DOI: 10.3760/cma.j.issn.2095-4352.2016.12.002.

Cardiopulmonary Resuscitation Specialized Committee of Chinese Research Hospital Association National consensus on cardiopulmonary resuscitation in China in 2016 Chin Crit Care Med 2016 28 12 1059 1079 10.3760/cma.j.issn.2095-4352.2016.12.002 Cardiopulmonary Resuscitation Specialized Committee of Chinese Research Hospital Association. National consensus on cardiopulmonary resuscitation in China in 2016[J]. Chin Crit Care Med, 2016, 28(12): 1059-1079. DOI: 10.3760/cma.j.issn.2095-4352.2016.12.002.

ZHANG Y LI C S WU C J Comparison of cerebral metabolism between pig ventricular fibrillation and asphyxial cardiac arrest models Chin Med J (Engl) 2015 128 12 1643 1648 10.4103/0366-6999.158340 ZHANG Y, LI C S, WU C J, et al .Comparison of cerebral metabolism between pig ventricular fibrillation and asphyxial cardiac arrest models[J ] . Chin Med J (Engl), 2015, 128(12): 1643-1648.DOI: 10.4103/0366-6999.158340.

LIPINSKI C A HICKS S D CALLAWAY C W Normoxic ventilation during resuscitation and outcome from asphyxial cardiac arrest in rats Resuscitation 1999 42 3 221 229 10.1016/s0300-9572(99)00083-0 LIPINSKI C A, HICKS S D, CALLAWAY C W. Normoxic ventilation during resuscitation and outcome from asphyxial cardiac arrest in rats[J]. Resuscitation, 1999, 42(3): 221-229. DOI:10.1016/s0300-9572(99)00083-0.

HU T Y WANG J J WANG S W Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model Sci Rep 2019 9 1 16500 10.1038/s41598-019-52477-y HU T Y, WANG J J, WANG S W, et al . Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model[J ] . Sci Rep, 2019, 9(1): 16500. DOI:10.1038/s41598-019-52477-y.

VAN ZELLEM L DE JONGE R VAN ROSMALEN J High cumulative oxygen levels are associated with improved survival of children treated with mild therapeutic hypothermia after cardiac arrest Resuscitation 2015 90 150 157 10.1016/j.resuscitation.2014.12.013 VAN ZELLEM L, DE JONGE R, VAN ROSMALEN J, et al . High cumulative oxygen levels are associated with improved survival of children treated with mild therapeutic hypothermia after cardiac arrest[J ] . Resuscitation, 2015, 90: 150-157. DOI:10.1016/j.resuscitation. 2014.12.013.

YOUN C S PARK K N KIM S H The cumulative partial pressure of arterial oxygen is associated with neurological outcomes after cardiac arrest treated with targeted temperature management Crit Care Med 2018 46 4 e279 e285 10.1097/CCM.0000000000002935 YOUN C S, PARK K N, KIM S H, et al . The cumulative partial pressure of arterial oxygen is associated with neurological outcomes after cardiac arrest treated with targeted temperature management[J ] . Crit Care Med, 2018, 46(4): e279-e285. DOI:10.1097/CCM. 0000000000002935.

ZHOU D W LI Z M ZHANG S L The optimal peripheral oxygen saturation may be 95-97% for post-cardiac arrest patients: a retrospective observational study Am J Emerg Med 2020 S0735 S6757 10.1016/j.ajem.2020.01.038 ZHOU D W, LI Z M, ZHANG S L, et al . The optimal peripheral oxygen saturation may be 95-97% for post-cardiac arrest patients: a retrospective observational study[J ] . Am J Emerg Med, 2020: S0735-S6757(20)30038-3. DOI:10.1016/j.ajem.2020.01.038.

DAMIANI E DONATI A GIRARDIS M Oxygen in the critically ill Curr Opin Anaesthesiol 2018 31 2 129 135 10.1097/aco.0000000000000559 DAMIANI E, DONATI A, GIRARDIS M. Oxygen in the critically ill[J]. Curr Opin Anaesthesiol, 2018, 31(2): 129-135. DOI:10.1097/aco.0000000000000559.

DENG R X XIONG W JIA X F Electrophysiological monitoring of brain injury and recovery after cardiac arrest Int J Mol Sci 2015 16 11 25999 26018 10.3390/ijms161125938 DENG R X, XIONG W, JIA X F. Electrophysiological monitoring of brain injury and recovery after cardiac arrest[J]. Int J Mol Sci, 2015, 16(11): 25999-26018. DOI:10.3390/ijms161125938.

SADAKA F DOERR D HINDIA J Continuous electroencephalogram in comatose postcardiac arrest syndrome patients treated with therapeutic hypothermia: outcome prediction study J Intensive Care Med 2015 30 5 292 296 10.1177/0885066613517214 SADAKA F, DOERR D, HINDIA J, et al . Continuous electroencephalogram in comatose postcardiac arrest syndrome patients treated with therapeutic hypothermia: outcome prediction study[J ] . J Intensive Care Med, 2015, 30(5): 292-296. DOI:10.1177/0885066613517214.

NOIRHOMME Q LEHEMBRE R DEL ROSARIO LUGO Z Automated analysis of background EEG and reactivity during therapeutic hypothermia in comatose patients after cardiac arrest Clin EEG Neurosci 2014 45 1 6 13 10.1177/1550059413509616 NOIRHOMME Q, LEHEMBRE R, DEL ROSARIO LUGO Z, et al . Automated analysis of background EEG and reactivity during therapeutic hypothermia in comatose patients after cardiac arrest[J ] . Clin EEG Neurosci, 2014, 45(1): 6-13. DOI:10.1177/1550059413509616.

OH S H PARK K N SHON Y M Continuous amplitude-integrated electroencephalographic monitoring is a useful prognostic tool for hypothermia-treated cardiac arrest patients Circulation 2015 132 12 1094 1103 10.1161/CIRCULATIONAHA.115.015754 OH S H, PARK K N, SHON Y M, et al . Continuous amplitude-integrated electroencephalographic monitoring is a useful prognostic tool for hypothermia-treated cardiac arrest patients[J ] . Circulation, 2015, 132(12): 1094-1103. DOI:10.1161/CIRCULATIONAHA. 115.015754.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Protective effect of hypoxia-inducible factor-1α on brain injury in mice with necrotizing enterocolitis

Effects of necrotizing enterocolitis on brain injury and its severity in neonatal mice

Correlation of serum bilirubin with quantitative electroencephalographic parameters in neonatal infants

Protective effect of sodium butyrate on brain injury in mice with necrotizing enterocolitis

Role of Notch signaling in hyperoxia-induced oligodendrocyte maturation disorder of neonatal mice

Related Author

Ying XU

Wei ZHAO

Yujuan YU

Xue WANG

Mou ZOU

Xue WANG

Mou ZOU

Shaoqing ZHANG

Related Institution

Department of Anesthesiology, National Clinical Research Center for Child Health and Disorders, Key Laboratory of Child Development and Disorders of Ministry of Education, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University

Department of Neonatology, the Third Xiangya Hospital, Central South University

Department of Pediatrics, the First Changsha Hospital

⁰