Influencing factors of non-sentinel lymph node metastasis in breast cancer patients with 1~2 positive sentinel lymph nodes

Lei MENG; Qi XIAO; Zhao LI; Junfeng HE; Yuanyuan WANG; Jinxiang TAN

doi:10.16016/j.1000-5404.201912219

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Influencing factors of non-sentinel lymph node metastasis in breast cancer patients with 1~2 positive sentinel lymph nodes

更新时间：2026-01-09

- Influencing factors of non-sentinel lymph node metastasis in breast cancer patients with 1~2 positive sentinel lymph nodes
- Journal of Third Military Medical University Vol. 42, Issue 11, Pages: 1130-1135(2020)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the National Natural Science Foundation for Young Scholars of China(81102008)
- DOI：10.16016/j.1000-5404.201912219
  CLC：
- Received：24 December 2019，
  
  Published：15 June 2020
- 稿件说明：
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Lei MENG, Qi XIAO, Zhao LI, et al. Influencing factors of non-sentinel lymph node metastasis in breast cancer patients with 1~2 positive sentinel lymph nodes[J]. Journal of Third Military Medical University, 2020, 42(11): 1130-1135.
DOI：

Lei MENG, Qi XIAO, Zhao LI, et al. Influencing factors of non-sentinel lymph node metastasis in breast cancer patients with 1~2 positive sentinel lymph nodes[J]. Journal of Third Military Medical University, 2020, 42(11): 1130-1135. DOI： 10.16016/j.1000-5404.201912219.

摘要

Abstract

Objective

To investigate the metastasis of non-sentinel lymph node (NSLN) in breast cancer patients with 1~2 positive axillary sentinel lymph nodes (SLN) and the related risk factors.

Methods

Clinicopathologic parameters of 383 breast cancer patients with 1~2 positive SLNs admitted in our hospital from 2016 to 2018 were collected and retrospectively studied. Univariate and multivariate analysis were used to explore the related predictors of NSLN metastasis.

Results

In the enrolled 383 patients

only 149 (38.9%) were observed with NSLN metastasis. Univariate analysis showed ultrasound axillary lymph node (ALN)

status (

0.001)

number of positive SLN (

=0.007)

number of negative SLN (

0.001)

number of SLN dissected (

0.001)

metastatic rate of SLN (

0.001) and lymph-vascular invasion (LVI

=0.003) were related with NSLN metastasis. Multivariate logistic regressive analysis indicated that ultrasound ALN status (

=0.001)

number of negative SLN (

=0.019)

metastatic rate of SLN (

=0.037)

LVI (

=0.039) and HER2 over-expression (

=0.026) were the independent predictive factors of NSLN metastasis.

Conclusion

Ultrasound ALN status

number of negative SLN

metastatic rate of SLN

LVI and HER2 over-expression can be used as the independent predictive factors of NSLN metastasis. Attention should be paid to the clinicopathological characteristics when decision of avoiding axillary lymph node dissection in breast cancer patients with 1~2 positive SLNs.

关键词

Keywords

references

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