Evaluation of rabbit left ventricular systolic function at low temperature by two-dimensional speckle-tracking echocardiography

Dongni WANG; Junying CAO; Lulu WU; Yi WANG; Fang LIU; Yingna DONG

doi:10.16016/j.1000-5404.201912187

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Evaluation of rabbit left ventricular systolic function at low temperature by two-dimensional speckle-tracking echocardiography

更新时间：2026-01-09

- Evaluation of rabbit left ventricular systolic function at low temperature by two-dimensional speckle-tracking echocardiography
- Journal of Third Military Medical University Vol. 42, Issue 11, Pages: 1086-1090(2020)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the General Program of the "Twelfth Five-year Plan" of PLA(CSY13J005)
- DOI：10.16016/j.1000-5404.201912187
  CLC：
- Received：19 December 2019，
  
  Published：15 June 2020
- 稿件说明：
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Dongni WANG, Junying CAO, Lulu WU, et al. Evaluation of rabbit left ventricular systolic function at low temperature by two-dimensional speckle-tracking echocardiography[J]. Journal of Third Military Medical University, 2020, 42(11): 1086-1090.
DOI：

Dongni WANG, Junying CAO, Lulu WU, et al. Evaluation of rabbit left ventricular systolic function at low temperature by two-dimensional speckle-tracking echocardiography[J]. Journal of Third Military Medical University, 2020, 42(11): 1086-1090. DOI： 10.16016/j.1000-5404.201912187.

摘要

Abstract

Objective

To investigate the change of left ventricular systolic function in rabbits at low temperature by using two-dimensional speckle-tracking technique.

Methods

Thirty New Zealand rabbits were randomly and equally divided into control group

hypothermia for 4 h(group A) and for 8 h(group B) groups. After routine cardiac measurements were performed firstly

then tissue Doppler imaging (TDI) was carried out to record peaks in the S

E and Aspectra of the septal side of the mitral valve

followed by speckle-tracking imaging (STI) to obtain global peak longitudinal strain (SL)

circumferential strain (SC) and radial strain (SR)

and the peak values in the basal

medium and apical segments. The indexes of myocardial enzyme spectrum were detected by hematology

and the changes of myocardial pathology were observed by HE staining.

Results

Significant differences were seen in the conventional ultrasound parameters

such as left ventricular end-systolic diameter (LAESd)

left ventricular end-diastolic diameter (LVEDd)

left ventricular ejection fraction (LVEF)

peak systolic velocity (Sm)

peak early diastolic velocity (Em)

and peak end diastolic velocity (Am) between the control group and group B(

0.05). Compared with the control group

the global SL

SC and SR and the values in apical segment were obviously decreased in group A

and the above global values and those in basal

medium and apical segments were all reduced in group B(

0.05). The global SL and SR values and those in the 3 segments were notably lower in group Bthan group A(

0.05). The serum levels of aspartate aminotransferase (AST)

creatine kinase (CK)

creatine kinase isozyme (CK-MB)

and high-sensitivity cardiac troponin T(HS-TNT) were significantly increased in groups Aand Bthan the control group (

0.05). HE staining showed that partially broken myocardial fibers

disintegrated cardiomyocytes

dissolved nuclei

lightly stained chromatin

and Alot of inflamma

tory cells were seen in group B.

Conclusions

With the extension of low temperature time

the myocardial tissue shows damage at different degrees. Two-dimensional speckle-tracking technology can find declined left ventricular function earlier than LVEF and TDI.

关键词

Keywords

references

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