Significance of retinal structural and functional damage in diagnosis of Alzheimer's disease

Hanyun WU; Xin LI; Zhangjin QIN; Wenkai YANG; Yang LYU; Li ZHANG

doi:10.16016/j.1000-5404.201912022

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Significance of retinal structural and functional damage in diagnosis of Alzheimer's disease

更新时间：2026-01-09

- Significance of retinal structural and functional damage in diagnosis of Alzheimer's disease
- Journal of Third Military Medical University Vol. 42, Issue 8, Pages: 848-854(2020)
- 作者机构：
- 作者简介：
- 基金信息：
  
  Supported by the General Project of Graduate Education Reform Program of Chongqing Municipal Education Committee(yjg153108)
- DOI：10.16016/j.1000-5404.201912022
  CLC：
- Received：03 December 2019，
  
  Published：30 April 2020
- 稿件说明：
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Hanyun WU, Xin LI, Zhangjin QIN, et al. Significance of retinal structural and functional damage in diagnosis of Alzheimer's disease[J]. Journal of Third Military Medical University, 2020, 42(8): 848-854.
DOI：

Hanyun WU, Xin LI, Zhangjin QIN, et al. Significance of retinal structural and functional damage in diagnosis of Alzheimer's disease[J]. Journal of Third Military Medical University, 2020, 42(8): 848-854. DOI： 10.16016/j.1000-5404.201912022.

摘要

Abstract

Objective

To assess the value of detecting retinal changes with pattern visual evoked potential (PVEP) combined with optical coherence tomography (OCT) in the diagnosis of Alzheimer's disease (AD).

Methods

This study was conducted among 31 patients with established diagnosis of AD in the First Affiliated Hospital of Chongqing Medical University between August

2018 and November

2019

with 37 age-matched healthy elderly individuals from local community as the control group. All the subjects underwent examinations with both PVEP and OCT. The latency and amplitude of P100 wave in PVEP and peripapillary retinal nerve fiber layer (pRNFL) thickness in each quadrant in OCT were recorded and compared between the two groups to assess the diagnostic value of these parameters for AD.

Results

Compared with the healthy control group

the patients with AD had significantly lowered amplitude of P100 wave (

0.05) without obvious changes in the latency of P100 wave (

0.05); they also exhibited significantly thinner pRNFL in the nasal

superonasal

superotemporal and inferotemporal quadrants (

0.05)

but not in the temporal or inferonasal quadrant (

0.05). ROC curve analysis showed that the area under curve (AUC) of a single functional or structural parameter of the retina was smaller than that of multiple retinal parameters combined.

Conclusion

The amplitude of P100 wave combined with superonasal and superotemporal pRNFL thickness has a high diagnostic value for AD

which supports the combination of PVEP and OCT for clinical diagnosis of AD.

关键词

Keywords

references

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