Progress in <italic style="font-style: italic">Fusobacterium nucleatum</italic>

Xuhu MAO; Yanan TONG

doi:10.16016/j.1000-5404.201908133

您当前的位置：

首页 >

文章列表页 >

Progress in Fusobacterium nucleatum

Expert Reviews | 更新时间：2026-01-09

- Progress in Fusobacterium nucleatum
- Journal of Third Military Medical University Vol. 41, Issue 19, Pages: 1867-1872(2019)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)药学与检验医学系临床微生物与免疫学教研室
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201908133
  CLC： R378.99
- Received：18 August 2019，
  
  Revised：2019-09-01，
  
  Published：15 October 2019
- 稿件说明：
移动端阅览
Xuhu MAO, Yanan TONG. Progress in Fusobacterium nucleatum[J]. Journal of Third Military Medical University, 2019, 41(19): 1867-1872.
DOI：

Xuhu MAO, Yanan TONG. Progress in Fusobacterium nucleatum[J]. Journal of Third Military Medical University, 2019, 41(19): 1867-1872. DOI： 10.16016/j.1000-5404.201908133.

摘要

具核梭杆菌(

Fusobacterium nucleatum

nucleatum

)是口腔微生物群中常驻成员，并且可以与其宿主产生共生关系。具核梭杆菌能够引起多种机会性感染。最近的研究发现其感染与结直肠癌的发生、发展密切相关。现就具核梭杆菌与宿主的共生关系、作为感染因子在疾病中的角色，以及促进肿瘤进程的作用等方面进行评述，并深入探讨目前对该菌的一些新见解和未来的研究方向。这些新观点希望可以帮助我们不断认识具核梭杆菌及其促进结直肠癌作用的新机制，为寻找具核梭杆菌诊断与治疗的新方法提供依据。

Abstract

Fusobacterium nucleatum

(

nucleatum

) is one of the resident members in oral microflora

and has a symbiotic relationship with the host.

nucleatum

can cause a variety of opportunistic infections

and many recent studies have linked it to the occurrence and development of colorectal cancer. In this paper

we review the symbiotic relationship between

nucleatum

and its host

and its roles as an infectious factor in disease and as a promoter for tumor progress. In addition

some new views and future research directions of this bacterium are also discussed. We hope that these new ideas will help us understand the role of

nucleatum

in promoting colorectal cancer and the related mechanisms

as well as provide a basis for new methods in the diagnosis and treatment of

nucleatum

associated colorectal cancer.

关键词

Keywords

references

PARKS D H, RINKE C, CHUVOCHINA M, et al .Recovery of nearly 8, 000 metagenome-assembled genomes substantially expands the tree of life[J ] .Nat Microbiol, 2017, 2(11): 1533-1542.DOI:10.1038/s41564-017-0012-7.

ALLAN L, TRUANT, SUSAN MENGE, et al . Fusobacterium nucleatum pericarditis[J ] .J Clin Microbiol, 1983, 17(2):349-351..

HAN X Y, WEINBERG J S, PRABHU S S, et al .Fusobacterial brain abscess: a review of five cases and an analysis of possible pathogenesis[J ] .J Neurosurg, 2003, 99(4): 693-700.DOI:10.3171/jns.2003.99.4.0693.

SWIDSINSKI A, DORFFEL Y, LOENING-BAUCKE V, et al . Acute appendicitis is characterised by local invasion with Fusobacterium nucleatum /necrophorum[J ] .Gut, 2011, 60(1): 34-40.DOI:10.1136/gut.2009.191320..

GREGORY S W, BOYCE T G, LARSON A N, et al . Fusobacterium nucleatum osteomyelitis in 3 previously healthy children: A case series and review of the literature[J ] .J Pediatr Infect Dis Soc, 2015, 4(4): e155-e159.DOI:10.1093/jpids/piv052..

ALTSHULER G, HYDE S.Clinicopathologic considerations of fusobacteria chorioamnionitis[J].Acta Obstet Gynecol Scand, 1988, 67(6): 513-517.DOI:10.3109/0001634880902 9862.

KOLENBRANDER P E, PALMER R J Jr, PERIASAMY S, et al .Oral multispecies biofilm development and the key role of cell-cell distance[J ] .Nat Rev Microbiol, 2010, 8(7): 471-480.DOI:10.1038/nrmicro2381.

LANCY P JR, DIRIENZO J M, APPELBAUM B, et al .Corncob formation between Fusobacterium nucleatum and Streptococcus sanguis [J ] .Infect Immun, 1983, 40(1): 303-309..

KAPLAN C W, MA X Y, PARANJPE A, et al . Fusobacterium nucleatum outer membrane pro teins Fap2 and RadD induce cell death in human lymphocytes[J ] .Infect Immun, 2010, 78(11): 4773-4778.DOI:10.1128/IAI.00567-10..

HENDRICKSON E L, WANG T S, BECK D A, et al .Proteomics of Fusobacterium nucleatum within a model developing oral microbial community[J ] .Microbiologyopen, 2014, 3(5): 729-751.DOI:10.1002/mbo3.204..

TAN K H, SEERS C A, DASHPER S G, et al . Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses[J ] .PLoS Pathog, 2014, 10(3): e1003955.DOI:10.1371/journal.ppat.1003955..

SAITO A, KOKUBU E, INAGAKI S, et al .Porphyromonas gingivalis entry into gingival epithelial cells modulated by Fusobacterium nucleatum is dependent on lipid rafts[J ] . Microb Pathog, 2012, 53(5/6): 234-242.DOI:10.1016/j.micpath.2012.08.005..

METZGER Z, LIN Y Y, DIMEO F, et al .Synergistic pathogenicity of Porphyromonas gingivalis and Fusobacterium nucleatum in the mouse subcutaneous chamber model[J ] .J Endod, 2009, 35(1): 86-94.DOI:10.1016/j.joen.2008.10.015..

HAN Y W, REDLINE R W, LI M, et al . Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth[J ] .Infect Immun, 2004, 72(4): 2272-2279.DOI:10.1128/iai.72.4.2272-2279.2004..

AAGAARD K, MA J, ANTONY K M, et al .The placenta harbors a unique microbiome[J ] .Sci Transl Med, 2014, 6(237): 237ra65.DOI:10.1126/scitranslmed.3008599.

KINDER HAAKE S, LINDEMANN R A. Fusobacterium nucleatum T18 aggregates human mononuclear cells and inhibits their PHA-stimulated proliferation[J ] .J Periodontol, 1997, 68(1): 39-44.DOI:10.1902/jop.1997.68.1.39.

HATAKEYAMA M.Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis[J].Cell Host Microbe, 2014, 15(3): 306-316.DOI:10.1016/j.chom.2014.02.008.

KOSTIC A D, CHUN E, ROBERTSON L, et al . Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment[J ] .Cell Host Microbe, 2013, 14(2): 207-215.DOI:10.1016/j.chom.2013.07.007..

KOSTIC A D, GEVERS D, PEDAMALLU C S, et al . Genomic analysis identifies association of Fusobacterium with colorectal carcinoma[J ] .Genome Res, 2012, 22(2): 292-298.DOI:10.1101/gr.126573.111..

MCCOY A N, ARAÚJO-PÉREZ F, AZCÁRATE-PERIL A, et al . Fusobacterium is associated with colorectal adenomas[J ] .PLoS ONE, 2013, 8(1): e53653.DOI:10.1371/journal.pone.0053653..

SU L K, KINZLER K W, VOGELSTEIN B, et al .Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene[J ] .Science, 1992, 256(5057): 668-670.DOI:10.1126/science.1350108.

KOMIYA Y, SHIMOMURA Y, HIGURASHI T, et al . Patients with colorectal cancer have identical strains of Fusobacterium nucleatum in their colorectal cancer and oral cavity[J ] .Gut, 2019, 68(7): 1335-1337.DOI:10.1136/gutjnl-2018-316661..

YANG G Y, SHAMSUDDIN A M.Gal-GalNAc: a biomarker of colon carcinogenesis[J].Histol Histopathol, 1996, 11(3): 801-806.

RUBINSTEIN M R, WANG X W, LIU W, et al . Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin[J ] .Cell Host Microbe, 2013, 14(2): 195-206.DOI:10.1016/j.chom.2013.07.012..

YU T, GUO F F, YU Y N, et al . Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy[J ] .Cell, 2017, 170(3): 548-563.e16.DOI:10.1016/j.cell.2017.07.008..

GUR C, IBRAHIM Y, ISAACSON B, et al .Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack[J ] .Immunity, 2015, 42(2): 344-355.DOI:10.1016/j.immuni.2015.01.010..

DOUGALL W C, KURTULUS S, SMYTH M J, et al .TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy[J ] .Immunol Rev, 2017, 276(1): 112-120.DOI:10.1111/imr.12518.

NOUGAYRÈDE J P, HOMBURG S, TAIEB F, et al . Escherichia coli induces DNA double-strand breaks in eukaryotic cells[J ] .Science, 2006, 313(5788): 848-851.DOI:10.1126/science.1127059..

SANDERS B E, UMANA A, LEMKUL J A, et al . FusoPortal: an interactive repository of hybrid MinION-sequenced Fusobacterium genomes improves gene identification and characterization[J ] .mSphere, 2018, 3(4): e00228-e00218.DOI:10.1128/mSphere.00228-18..

ZARKAVELIS G, BOUSSIOS S, PAPADAKI A, et al .Current and future biomarkers in colorectal cancer[J ] .Ann Gastroenterol, 2017, 30(6): 613-621.DOI:10.20524/aog.2017.0191.

WANG H F, LI L F, GUO S H, et al .Evaluation of antibody level against Fusobacterium nucleatum in the serological diagnosis of colorectal cancer[J ] .Sci Rep, 2016, 6: 33440.DOI:10.1038/srep33440..

TAHARA T, YAMAMOTO E, SUZUKI H, et al . Fusobacterium in colonic flora and molecular features of colorectal carcinoma[J ] .Cancer Res, 2014, 74(5): 1311-1318.DOI:10.1158/0008-5472.CAN-13-1865..

DEJEA C M,FATHI P, CRAIG J M, et al .Patients with fa milial adenomatous polyposis harbor colonic biofilms containing tumorigenic Bacteria[J ] .Science, 2018, 359(6375): 592-597.DOI:10.1126/science.aah3648.

BY WILLIAM JOHN HANNAN MCBRIDE R.Mandell, Douglas and Bennett's principles and practice of infectious diseases 7th edition[J].Sex Health, 2010, 7(2): 218.DOI:10.1071/shv7n2_br3.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

MiR-543/SNTB1 axis modulates immune microenvironment in colorectal cancer

Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancer

Preparation of nanosized hypoxia-inducible factor 1α inhibitor and its application in reversing chemoresistance in colorectal cancer cells

Plateau hypoxia improves tumor immune microenvironment and inhibits subcutaneous tumor growth of colorectal cancer

Association between polymorphisms of human positive coactivator 4 gene promoter and risk of colorectal cancer

Related Author

ZHANG Min

LI Min

XIAO Meng

CHEN Cai

ZHENG Xiaoju

LEI Yuguang

ZHAO Wensi

SONG Jian

Related Institution

School of Medicine, Xinyang Hospital of Traditional Chinese Medicine

School of Pharmaceutical Sciences， Xinyang Vocational and Technical College， Xinyang， Henan, Xinyang Hospital of Traditional Chinese Medicine

Department of Pathology, Xinyang Hospital of Traditional Chinese Medicine

Department of Oncology, Renmin Hospital of Wuhan University

Department of Pharmacy, Renmin Hospital of Wuhan University

⁰

Progress in Fusobacterium nucleatum

DOI：10.16016/j.1000-5404.201908133

摘要

Abstract

关键词

Keywords

references