Influence of timing of prophylactic antibiotics for premature rupture of membranes on maternal and infant outcomes

Mingyu ZHENG; Lili CAO; Shuhua YI; Lu DONG; Ruiwei WANG; Dan WANG; Qing CHANG

doi:10.16016/j.1000-5404.201908053

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Influence of timing of prophylactic antibiotics for premature rupture of membranes on maternal and infant outcomes

Clinical Medicine | 更新时间：2026-01-09

- Influence of timing of prophylactic antibiotics for premature rupture of membranes on maternal and infant outcomes
- Journal of Third Military Medical University Vol. 42, Issue 2, Pages: 197-201(2020)
- 作者机构：
  
  1.400038 重庆，陆军军医大学(第三军医大学)第一附属医院:药学部
  2.400038 重庆，陆军军医大学(第三军医大学)第一附属医院:妇产科
  3.400037 重庆，陆军军医大学(第三军医大学)第二附属医院药学部
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201908053
  CLC： R714.433; R715.3; R978.1
- Received：07 August 2019，
  
  Revised：2019-09-15，
  
  Published：30 January 2020
- 稿件说明：
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Mingyu ZHENG, Lili CAO, Shuhua YI, et al. Influence of timing of prophylactic antibiotics for premature rupture of membranes on maternal and infant outcomes[J]. Journal of Third Military Medical University, 2020, 42(2): 197-201.
DOI：

Mingyu ZHENG, Lili CAO, Shuhua YI, et al. Influence of timing of prophylactic antibiotics for premature rupture of membranes on maternal and infant outcomes[J]. Journal of Third Military Medical University, 2020, 42(2): 197-201. DOI： 10.16016/j.1000-5404.201908053.

摘要

目的

探讨产前预防使用抗生素的时机对于足月胎膜早破孕妇母婴结局的影响。

方法

回顾性分析2016年1月至2017年12月在我院产科住院分娩的246例低危足月胎膜早破孕妇病例，以预防用药距破膜时间8 h为界将病例分为A组(< 8 h)和B组(≥8 h)；再以12 h为界行亚组分析，分为C亚组(8~12 h)和D亚组(> 12 h)；以18 h为界行亚组分析，分为E组(12~18 h)和F组(> 18 h)。收集母婴感染指标及结局。

结果

A组与B组孕妇分娩前、后感染指标及母婴不良结局发生率，差异无统计学意义；C组新生儿脐动脉血pH值高于D组，差异有统计学意义(

0.05)，但均在正常范围；其余感染指标及母婴不良结局发生率差异无统计学意义。E组产前WBC值及Neu%均高于F组，E组产后PCT值低于F组，WBC值和PCT值差异有统计学意义(

0.05)，其余感染指标及母婴不良结局发生率差异无统计学意义。

结论

对于低危的足月胎膜早破孕妇分娩前可适当推迟抗生素使用时间，即 > 18 h。

Abstract

Objective

To explore the influence of the timing of prophylactic antibiotic treatment for premature rupture of membranes on maternal and infant outcomes.

Methods

We retrospectively analyzed the data of 246 cases of low-risk premature rupture of membranes in our hospital between January

2016 and December

2017. According to the timing of prophylactic antibiotic treatment

the cases were divided into groups A and B with the antibiotics administered within 8 h and over 8 h

groups C and D with drug administration in 8–12 h and > 12 h

and groups E and F with administration in 12-18 h and > 18 h prior to premature rupture of membranes

respectively. The incidence of maternal infections and the maternal and infant outcomes were compared among the groups.

Results

No significant differences were found between groups A and B in the indicators of maternal infection either before or after the delivery or in the occurrence of adverse maternal and infant outcomes. The pH value of umbilic

al arterial blood was significantly higher in group C than in group D (

0.05)

but all within the normal range. The prenatal WBC count and Neu% was significantly higher in group E than in group F (

0.05)

and the postpartum PCT was significantly higher in group F than in group E (

0.05); the other infection indicators or the occurrence of adverse maternal and infant outcomes did not differ significantly between the 2 groups.

Conclusion

In pregnant women with low-risk full-term premature rupture of membranes

prophylactic administration of antibiotics can be delayed to > 18 h before delivery.

关键词

Keywords

references

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