Incidence and risk factors for <italic style="font-style: italic">Clostridium difficile</italic> infection in patients with diarrhea during autologous hematopoietic stem cell transplantation

Lei MAO; Bing XIA; Chen TIAN; Haifeng ZHAO; Hongliang YANG; Yong YU; Jing CHEN; Yizhuo ZHANG

doi:10.16016/j.1000-5404.201907204

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Incidence and risk factors for Clostridium difficile infection in patients with diarrhea during autologous hematopoietic stem cell transplantation

更新时间：2026-01-09

- Incidence and risk factors for Clostridium difficile infection in patients with diarrhea during autologous hematopoietic stem cell transplantation
- Journal of Third Military Medical University Vol. 41, Issue 23, Pages: 2285-2289(2019)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201907204
  CLC：
- Received：26 July 2019，
  
  Published：25 December 2019
- 稿件说明：
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Lei MAO, Bing XIA, Chen TIAN, et al. Incidence and risk factors for Clostridium difficile infection in patients with diarrhea during autologous hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2019, 41(23): 2285-2289.
DOI：

Lei MAO, Bing XIA, Chen TIAN, et al. Incidence and risk factors for Clostridium difficile infection in patients with diarrhea during autologous hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2019, 41(23): 2285-2289. DOI： 10.16016/j.1000-5404.201907204.

摘要

Abstract

Objective

To investigate the incidence and risk factors for

Clostridium difficile

infection (CDI) in patients with diarrhea during autologous hematopoietic stem cell transplantat

ion (auto-HSCT) and provide guidance for clinical diagnosis and treatment.

Methods

Clinical data of patients with diarrhea during auto-HSCT between May 2005 and July 2019 were collected and retrospectively analyzed. The patients with positive results of

Clostridium difficile

anaerobic culture and

Clostridium difficile

toxin A/B test were assigned into the CDI group

and the others were into the non-CDI group. The incidence and risk factors for CDI were analyzed in this case-control study.

Results

A total of 202 patients developed diarrhea during auto-HSCT in this study. Thirty-three patients suffered from CDI

with an incidence rate of 16.3% and a median onset of 12(8~17) d since the admission of transplantation ward. The results of the univariate analysis indicated that the incidence of CDI was associated with the administration of busulfan

bortezomib and carmustine (all

0.05). The multivariate analysis showed that busulfan and bortezomib were the independent risk factors for CDI (all

0.05). The median time of diarrhea was 6(4~9) d in CDI patients

and 2 patients (6.0%) developed septic shock and died.

Conclusion

The incidence rate of CDI is quite high in the patients with diarrhea during auto-HSCT. The administration of busulfan and bortezomib are risk factors for CDI.

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Keywords

references

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⁰

Incidence and risk factors for Clostridium difficile infection in patients with diarrhea during autologous hematopoietic stem cell transplantation

DOI：10.16016/j.1000-5404.201907204

摘要

Abstract

关键词

Keywords

references