Combination of transcranial ultrasound and susceptibility weighted imaging in diagnosis of Parkinsonism

Cuncheng ZHANG; Jing LING; Ying HUANG; Yaling DU; Zhigang WANG; Qilin LI

doi:10.16016/j.1000-5404.201907201

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Combination of transcranial ultrasound and susceptibility weighted imaging in diagnosis of Parkinsonism

Neurosciences | 更新时间：2026-01-09

- Combination of transcranial ultrasound and susceptibility weighted imaging in diagnosis of Parkinsonism
- Journal of Third Military Medical University Vol. 42, Issue 1, Pages: 25-30(2020)
- 作者机构：
  
  1.400016 重庆，重庆医科大学附属第二医院超声科，超声分子影像重庆市重点实验室
  2.400014 重庆，中国科学院大学重庆医院，重庆市人民医院超声科
- 作者简介：
- 基金信息：
  
  the General Program of Medical Scientific Research of Chongqing Health Commission(2017MSXM054)
- DOI：10.16016/j.1000-5404.201907201
  CLC： R445.1;R742.5
- Received：26 July 2019，
  
  Revised：2019-09-29，
  
  Published：15 January 2020
- 稿件说明：
移动端阅览
Cuncheng ZHANG, Jing LING, Ying HUANG, et al. Combination of transcranial ultrasound and susceptibility weighted imaging in diagnosis of Parkinsonism[J]. Journal of Third Military Medical University, 2020, 42(1): 25-30.
DOI：

Cuncheng ZHANG, Jing LING, Ying HUANG, et al. Combination of transcranial ultrasound and susceptibility weighted imaging in diagnosis of Parkinsonism[J]. Journal of Third Military Medical University, 2020, 42(1): 25-30. DOI： 10.16016/j.1000-5404.201907201.

摘要

目的

研究帕金森综合征(Parkinsonism)人群利用经颅超声(transcranial ultrasound，TCS)发现中脑黑质回声增强(SN

)及磁敏感加权成像(susceptibility weighted imaging

SWI)发现“燕尾征”消失(loss of swallow tail sign，LSTS

)对帕金森病(Parkinson’s disease

PD)诊断的临床应用价值。

方法

以2016年7月至2018年12月在重庆市人民医院住院治疗的116例帕金森综合征患者为研究对象，其中62例为PD组，54例为非PD组。分析帕金森综合征人群中脑黑质TCS及SWI的图像特征，通过比较分别使用TCS发现SN

和SWI发现LSTS

，以及联合

使用以上两种方法诊断PD的敏感性与特异性和ROC曲线，研究TCS结合SWI在帕金森综合征诊断中的价值。

结果

PD患者SWI发现LSTS

及TCS发现SN

较非PD患者比例明显增高，以SN

与LSTS

为指标诊断帕金森病的敏感性、特异性、曲线下面积分别为80.6%、66.7%、0.737和88.7%、64.8%、0.768，联合应用两种指标诊断PD的敏感性、特异性、曲线下面面积分别为71.0%、88.9%、0.809。

结论

帕金森综合征患者人群中，使用TCS和SWI的结果为指标诊断PD的效能相似，但使用TCS的经济性与便捷性更佳，联合两种指标较单一指标诊断PD的敏感性下降，特异性有所提高。

Abstract

Objective

To analyze the diagnostic value of combination of transcranial ultrasound (TCS) found substantia nigra hyperechogenicity (SN

) and susceptibility weighted imaging (SWI) found loss of "swallow tail sign" (LSTS

) to diagnose parkinsonism

and assess the clinical value of TCS and SWI in the diagnosis of Parkinson's disease (PD).

Methods

A total of 116 patients with parkinsonism admitted the Chongqing People's Hospital from July 2016 to December 2018 were recruited in this study. And 62 of them were in the PD group and 54 in the non-PD group. The image features of TCS for nigra and SWI were analyzed in these parkinsonism patients. With SN

found by TCS and LSTS

found by SWI as indicators

receiver operating characteristic (ROC) curve was used to analyze the sensitivity

specificity

and area under the curve (AUC) of the 2 examinations alone or combined together in diagnosis of PD.

Results

There were more patients with SN

by TCS or LSTS

by SWI in the PD patients than the non-PD patients. The sensitivity

specificity and AUC of diagnosis of by using SN

and LSTS

to diagnose PD were 80.6%

66.7%

0.737 and 88.7%

64.8%

0.768

respectively. However

the sensitivity and specificity and AUC of their combination for the diagnosis were 71.0%

88.9%

and 0.809.

Conclusion

In patients with parkinsonism

the results of TCS and SWI have similar efficacy in the diagnosis of PD

but TCS is better in economics and convenience. Although the sensitivity is decreased when the 2 examinations combine together

the specificity is greatly improved.

关键词

Keywords

references

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