Clinical application of CAR-T cells in treatment of hematologic malignancies

Xi ZHANG; Ruihao HUANG

doi:10.16016/j.1000-5404.201907013

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Clinical application of CAR-T cells in treatment of hematologic malignancies

更新时间：2026-01-09

- Clinical application of CAR-T cells in treatment of hematologic malignancies
- Journal of Third Military Medical University Vol. 41, Issue 23, Pages: 2261-2266(2019)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the Special Project of Science and Technology Innovation for Social Undertakings and Livelihood Guarantee of Chongqing(CSTC2016shms-ztzx10003);the Clinical Project of Major Technology Innovation of Army Medical University(CX2019LC111);the Military and Civilian Integration Project of Clinical Major Innovative Technology From Second Affiliated Hospital of Army Medical University(2018JSLC0020)
- DOI：10.16016/j.1000-5404.201907013
  CLC：
- Received：02 July 2019，
  
  Published：25 December 2019
- 稿件说明：
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Xi ZHANG, Ruihao HUANG. Clinical application of CAR-T cells in treatment of hematologic malignancies[J]. Journal of Third Military Medical University, 2019, 41(23): 2261-2266.
DOI：

Xi ZHANG, Ruihao HUANG. Clinical application of CAR-T cells in treatment of hematologic malignancies[J]. Journal of Third Military Medical University, 2019, 41(23): 2261-2266. DOI： 10.16016/j.1000-5404.201907013.

摘要

Abstract

The stunning benefits of chimeric antigen receptor T (CAR-T) cell therapy in treatment of relapsed and/or refractory (R/R) B cell acute lymphoblastic leukemia have brought hope to the patients with R/R hematologic malignancies. With the aims of achieving more effective and more accessible CAR-T cell therapy

large-scale hospitals all over the world have launched clinical trails by adjusting the CAR structure

complementary treatment and management of side-effects. Great progresses had been made in the CAR structure optimization

efficiency and safety of clinical application

and transformation and survival of CAR-T cells. The process of clinical application of CAR-T cell therapy is gradually clear

and the effective measures for complications are gradually enriched. However

there still are some disappointing outcomes from clinical trails aimed at acute myeloblastic leukemia (AML)

which are the challenges badly in need of solutions. In order to finally grasp the success or failure

we must analyze the causes in multiple aspects

from preparation to clinical application

and continuously improve and optimize. In this paper

we sorted out the development trend of CAR-T cell therapy and problems needing be urgently solved in the treatment of hematological malignancies in recent years

and made the prospect for the future.

关键词

Keywords

references

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