Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation

Hongyun LIU; Guo CHEN; Yunjing ZENG; Xi ZHANG; Li GAO

doi:10.16016/j.1000-5404.201907007

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Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation

更新时间：2026-01-09

- Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation
- Journal of Third Military Medical University Vol. 41, Issue 23, Pages: 2296-2300(2019)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201907007
  CLC：
- Received：02 July 2019，
  
  Published：25 December 2019
- 稿件说明：
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Hongyun LIU, Guo CHEN, Yunjing ZENG, et al. Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2019, 41(23): 2296-2300.
DOI：

Hongyun LIU, Guo CHEN, Yunjing ZENG, et al. Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2019, 41(23): 2296-2300. DOI： 10.16016/j.1000-5404.201907007.

摘要

Abstract

Objective

To investigate the efficiency and safety of the infusion of umbilical cord mesenchymal stromal cells (UCMSCs) for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods

Clinical data of patients with hemorrhages cystitis after allo-HSCT in our medical center from January 2014 to December 2018 were collected and analyzed retrospectively in this study. The duration of hemorrhagic cystitis

response rate and pain scores were compared between the patients undergoing UCMSCs infusion (

=28) and those without (

=24). The safety of the infusion was also observed.

Results

The UCMSCs infusion group had significantly higher overall response rate (100.0%

45.8%

0.05)

shorter median time of pain disappearance (20.6±13.5

33.9±21.7 d

0.05)

and shorter duration of hematuria macroscopically (26.3±14.8

38.9±24.0 d

0.05) and microscopically (31

.3±13.6

48.9±22.0 d

0.05) when compared the infusion group. Infusion of UCMSCs had no effect on the infection rates of blood cytomegalovirus and urinary BK virus.

Conclusion

Infusion of UCMSCs can significantly shorten the course of hemorrhagic cystitis

reduce pain

improve general prognosis

and have no side effect in the patients after allo-HSCT.

关键词

Keywords

references

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