Expression and clinical significance of high mobility group protein B1 in patients with hemophagocytic lymphohistiocytosis

Ying CHEN; Hang SUN; Shifeng LOU; Kang ZHOU; Ying ZHANG; Shu CHEN; Yun LUO; Yan SHEN; Xianli LONG; Jianchuan DENG

doi:10.16016/j.1000-5404.201906057

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Expression and clinical significance of high mobility group protein B1 in patients with hemophagocytic lymphohistiocytosis

更新时间：2026-01-09

- Expression and clinical significance of high mobility group protein B1 in patients with hemophagocytic lymphohistiocytosis
- Journal of Third Military Medical University Vol. 41, Issue 23, Pages: 2307-2312(2019)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(81871608)
- DOI：10.16016/j.1000-5404.201906057
  CLC：
- Received：11 June 2019，
  
  Published：25 December 2019
- 稿件说明：
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Ying CHEN, Hang SUN, Shifeng LOU, et al. Expression and clinical significance of high mobility group protein B1 in patients with hemophagocytic lymphohistiocytosis[J]. Journal of Third Military Medical University, 2019, 41(23): 2307-2312.
DOI：

Ying CHEN, Hang SUN, Shifeng LOU, et al. Expression and clinical significance of high mobility group protein B1 in patients with hemophagocytic lymphohistiocytosis[J]. Journal of Third Military Medical University, 2019, 41(23): 2307-2312. DOI： 10.16016/j.1000-5404.201906057.

摘要

Abstract

Objective

To detect the expression of high mobility group box 1 (HMGB1) in hemophagocytic lymphohistiocytosis (HLH) patients and explore its clinical significance in the disease.

Methods

A total of 26 HLH patients admitted in our hospital from July 2018 to May 2019 were recruited

and their clinical data were collected in this study. Thirty healthy volunteers were recruited as normal control. The serum level and mRNA level of HMGB1 in peripheral blood samples were measured by ELISA and quantitative real-time PCR

respectively. The correlation between HMGB1 level and clinical data were analyzed

and the optimal cut-off value

sensitivity and specificity of HMGB1 for the diagnosis of HLH were analyzed.

Results

The serum HMGB1 level was significantly higher in HLH patients than healthy volunteers (1 992.77±883.74

1 237.49±272.85 ng/mL

0.01)

]

. And the mRNA level of the molecule was also obviously increased in the HLH patients than the heal

thy control (4.56±2.10

2.34±1.32

0.05). The serum level of HMGB1 was negatively correlated with red blood cell count (

=-0.514 6

0.05)

hemoglobin level (

=-0.453 6

0.05) and platelet count (

=-0.505 5

0.05). The serum level of HMGB1 was notably higher in the HLH patients with hemophagocytosis in bone marrow than those without (2 246.27±935.14

1 422.38±317.33 ng/mL

0.05). The area under the curve (AUC) of HLH diagnosed by HMGB1 was 0.812 2 (

0.05) and the optimal cut-off value was 1 522 ng/mL

with a sensitivity of 69.23% and specificity of 86.67%.

Conclusion

HMGB1 is highly expressed in the peripheral blood of HLH patients

and can be used in the diagnosis

evaluation and prognosis of the disease.

关键词

Keywords

references

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