Progress of a cause-unidentified disease: negative AIDS

Hongyan XIONG; Taiwu WANG

doi:10.16016/j.1000-5404.201905187

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Progress of a cause-unidentified disease: negative AIDS

Expert Reviews | 更新时间：2026-01-09

- Progress of a cause-unidentified disease: negative AIDS
- Journal of Third Military Medical University Vol. 41, Issue 19, Pages: 1832-1839(2019)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)军事预防医学系军队流行病学教研室
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201905187
  CLC： R181.37;R512.91
- Received：29 May 2019，
  
  Revised：2019-07-30，
  
  Published：15 October 2019
- 稿件说明：
移动端阅览
Hongyan XIONG, Taiwu WANG. Progress of a cause-unidentified disease: negative AIDS[J]. Journal of Third Military Medical University, 2019, 41(19): 1832-1839.
DOI：

Hongyan XIONG, Taiwu WANG. Progress of a cause-unidentified disease: negative AIDS[J]. Journal of Third Military Medical University, 2019, 41(19): 1832-1839. DOI： 10.16016/j.1000-5404.201905187.

摘要

近年来，我们研究小组跟踪观察了一群不被临床医生识别的、被称为“阴性艾滋病”或恐艾症的“患者”。由于“患者”主诉症状与临床常规检测结果不一致，往往被作为心理问题予以处置。调查显示，大多数“患者”是在不安全性行为后不久即发生类似感冒、呼吸道感染、肠道感染的症状，急性期后又出现持续、迁延的慢性症状，涉及咽喉、皮肤、肌肉、骨骼、神经等系统。“患者”因疾病所致的衰弱，生活质量明显下降。初步的血清学指标测试显示，“患者”体内存在明显的免疫功能异常及炎性反应。此外，其肠道细菌种类也发生了明显变化。进一步研究表明，“阴性艾滋病”“患者”与国际学术界报道的慢性疲劳综合征(chronic fatigue syndrome

CFS)在症状特征和认识历程方面非常相似。2015年，美国卫生部门确认CFS属于具有生物学基础的疾病，不是纯粹的心理问题。最新的研究信息显示，CFS与病原体感染有明显的关联，“患者”体内呈现免疫功能障碍，激素调节、新陈代谢和氧化应激反应异常等现象。由此，我们认为“阴性艾滋病”“患者”可能是CFS的一个病例亚组，其症状是因病原体感染引起的系列病理反应所致。现有临床常规检测指标项目的局限可能人为掩盖了疾病的危害效应。

Abstract

In recent years

our research team has followed up and observed a group of "patients" who are unknown by clinicians and called as "negative AIDS" or "AIDS phobia". Because the complaint symptoms of these "patients" are not consistent with the results of clinical routine tests

they are often treated as patients with psychological disorders. Our questionnaire investigation showed that most of the "patients" have symptoms similar to cold

respiratory tract infection and intestinal infection shortly after an unsafe sexual behavior. And after acute period

the chronic symptoms persist and delay

involving the pharynx

larynx

skin

muscle

skeleton

nerve and other systems. These "patients" are weakened by illness

and loss of the quality of life. The preliminary tests about serological indicators showed that there are obvious immunological abnormalities and inflammatory reactions

in vivo

. In addition

the analysis of gut microbiota diversity also showed significant changes. Further literature studies showed that "negative AIDS" patients are very similar to chronic fatigue syndrome (CFS) reported by international academic community in terms of symptomatic characteristics and cognitive process. In 2015

the U.S health departments confirmed that CFS is a biologically based disease

not a purely psychological problem. Recent research information shows that CFS is significantly associated with pathogenic infections. The patients present immune dysfunction and abnormal response in hormone regulation

metabolism and oxidative stress reaction. In summary

we could

propose that the "negative AIDS" patients may be a subgroup of CFS

whose symptoms are induced by a series of pathological reactions caused by pathogen infection. The limitations of current routine clinical indicators could artificially cover the hazard the disease.

关键词

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references

刘雅琼, 林辉, 于磊, 等.类获得性免疫缺陷(阴性HIV)"患者"的流行病学调查[J].第三军医大学学报, 2013, 35(5):369-375. DOI:10.16016/j.1000-5404.2013.05.001.

LIU Y Q, LIN H, YU L, et al .Epidemiological investigation of cases with complained AIDS-related complex (HIV negative)[J ] .J Third Mil Med Univ, 2013, 35(5):369-375. DOI:10.16016/j.1000-5404.2013.05.001.

裴迎新, 李兴旺, 张智清, 等.59例经网络征集的"自疑HIV感染者"流行病学特征与临床表现分析[J].中华流行病学杂志, 2010, 31(12):1379-1382.

PEI Y X, LI X W, ZHANG Z Q, et al . Epidemiologic and clinical characteristics of 59 persons suspecting of being infected by the HIV virus despite having repeated negative laboratory findings[J ] . Chin J Epidemiol, 2010, 31(12):1379-1382.

国家卫生计生委疾控局.阴滋病研讨会会议纪要(附件)[Z].2015.6.

Disease Control Bureau of National Health and Family Planning Commission. Summary of Seminar on negative-AIDS (Annex)[Z]. 2015.6.

KOMAROFF A L, FAGIOLI L R, GEIGER A M, et al . An examination of the working case definition of chronic fatigue syndrome[J ] . Am J Med, 1996, 100(1): 56-64. DOI:10.1016/s0002-9343(96)90012-1.

FUKUDA K, STRAUS S E, HICKIE I, et al . The chronic fatigue syndrome: a comprehensive approach to its definition and study. international chronic fatigue syndrome study group[J ] . Ann Intern Med, 1994, 121(12): 953-959. DOI:10.7326/0003-4819-121-12-199412150-00009.

CLAYTON E W. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: an IOM report on redefining an illness[J]. JAMA, 2015, 313(11): 1101-1102. DOI:10.1001/jama.2015.1346.

[REYES M, GARY JR. H E, DOBBINS J G, et al . Surveillance for chronic fatigue syndrome—four U.S. cities, September 1989 through August 1993[EB/OL ] . https://www.cdc.gov/mmwr/preview/mmwrhtml/00046433.htm?c_cid=journal_search_promotion_2018/ https://www.cdc.gov/mmwr/preview/mmwrhtml/00046433.htm?c_cid=journal_search_promotion_2018/ ..

[CDC. Myalgic encephalomyelitis/chronic fatigue syndrome[EB/OL ] .[2019-04-18 ] . https://www.cdc.gov/me-cfs/index.html https://www.cdc.gov/me-cfs/index.html .

COCKSHELL S J, MATHIAS J L. Cognitive functioning in chronic fatigue syndrome: a meta-analysis[J]. Psychol Med, 2010, 40(8): 1253-1267. DOI:10.1017/S003329170 9992054.

CHRISTLEY Y, DUFFY T, EVERALL I P, et al . The neuropsychiatric and neuropsychological features of chr onic fatigue syndrome: revisiting the enigma[J ] . Curr Psychiatry Rep, 2013, 15(4): 353. DOI:10.1007/s11920-013-0353-8.

BRODERICK G, CRADDOCK T J. Systems biology of complex symptom profiles: capturing interactivity across behavior, brain and immune regulation[J]. Brain Behav Immun, 2013, 29: 1-8. DOI:10.1016/j.bbi.2012.09.008.

徐聪, 王太武, 莫明露, 等.基于知识图谱的慢性疲劳综合征领域可视化研究[J].军事医学, 2015, 39(10): 781-786.

XU C, WANG T W, MO M L, et al . Visualization research in chronic fatigue syndrome based on mapping knowledge domain[J ] . Mil Med Sci, 2015, 39(10): 781-786.

[Group on Scientific Research into Myalgic Encephalomyelitis. Inquiry into the status of status of CFS/M.E. and research into causes and treatment[EB/OL ] .[2019-03-07 ] . http://www.erythos.com/gibsonenquiry/Docs/ME_Inquiry_Report.pdf http://www.erythos.com/gibsonenquiry/Docs/ME_Inquiry_Report.pdf .

[Chronic fatigue syndrome[EB/OL ] .[2019-04-06 ] . https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome https://en.wikipedia.org/wiki/Chronic_fatigue_syndrome .

[Chronic fatigue patients criticise study that says exercise can help[EB/OL ] .[2019-04-06 ] . https://www.theguardian.com/society/2015/oct/28/chronic-fatigue-patients-criticise-oxford-university-study-exercise-cbt-cfs https://www.theguardian.com/society/2015/oct/28/chronic-fatigue-patients-criticise-oxford-university-study-exercise-cbt-cfs .

[May 12 is ME/CFS and Fibromyalgia International Awareness Day.[2019-04-06 ] . https://www.cdc.gov/features/cfsawarenessday/ https://www.cdc.gov/features/cfsawarenessday/ .

[NINDS CDE Project: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDEs) Overall Working Group Summary.[EB/OL ] http://www.commondataelements.ninds.nih.gov/Doc/MECFS/MECFS_Overall_Working_Group_Summary.pdf http://www.commondataelements.ninds.nih.gov/Doc/MECFS/MECFS_Overall_Working_Group_Summary.pdf .

MORRIS G, MICHAEL M. Mechanisms explaining muscle fatigue and muscle pain in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a review of recent findings[J]. Curr Rheumatol Rep, 2017, 19(1): 1-10.

HULME K, HUDSON J L, ROJCZYK P, et al . Biop sychosocial risk factors of persistent fatigue after acute infection: A systematic review to inform interventions[J ] . J Psychosom Res, 2017, 99: 120-129. DOI:10.1016/j.jpsychores.2017.06.013.

MONTOYA J G, HOLMES T H, ANDERSON J N, et al . Cytokine signature associated with disease severity in chronic fatigue syndrome patients[J ] . Proc Natl Acad Sci USA, 2017, 114(34): E7150-E7158. DOI:10.1073/pnas.1710519114.

HATZIAGELAKI E, ADAMAKI M, TSILIONI I, et al . Myalgic encephalomyelitis/chronic fatigue syndrome-metabolic disease or disturbed homeostasis due to focal inflammation in the hypothalamus?[J ] . J Pharmacol Exp Ther, 2018, 367(1): 155-167. DOI:10.1124/jpet.118.250845.

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