Near infrared brain functional imaging of working memory in health young individuals

Li WANG; Linqiong SANG; Ye ZHANG; Jingna ZHANG; Yongjian NIAN; Pengyue LI; Liang QIAO; Mingguo QIU

doi:10.16016/j.1000-5404.201905034

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Near infrared brain functional imaging of working memory in health young individuals

Basic Medicine | 更新时间：2026-01-09

- Near infrared brain functional imaging of working memory in health young individuals
- Journal of Third Military Medical University Issue 21, Pages: 2061-2068(2019)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学) 生物医学工程系医学图像学教研室
- 作者简介：
- 基金信息：
  
  the Young Scientists Development Program of Third Military Medical University(2016XPY05);the Young Scientists Development Program of Third Military Medical University(2017XQN04);the Youth Training Program of Third Military Medical University(2018XQN04)
- DOI：10.16016/j.1000-5404.201905034
  CLC： R338.2;R338.64;R445.7
- Received：07 May 2019，
  
  Revised：2019-06-18，
  
  Published：15 November 2019
- 稿件说明：
移动端阅览
Li WANG, Linqiong SANG, Ye ZHANG, et al. Near infrared brain functional imaging of working memory in health young individuals[J]. Journal of Third Military Medical University, 2019, (21): 2061-2068.
DOI：

Li WANG, Linqiong SANG, Ye ZHANG, et al. Near infrared brain functional imaging of working memory in health young individuals[J]. Journal of Third Military Medical University, 2019, (21): 2061-2068. DOI： 10.16016/j.1000-5404.201905034.

摘要

目的

通过功能近红外光谱技术研究健康青年人工作记忆脑神经机制。

方法

选取本校在校师生23例，男性10例，女性13例，年龄20~24(22.48±1.24)岁。实验组块设计，利用近红外光谱技术对23例健康青年人进行数字正序、倒序记忆的数据采集，采用LAB_NIRS软件进行数据分析，分别探讨数字记忆的编码期、维持期、检索期的前额叶皮层的HbO

相对含量及脑区激活。

结果

数字正序记忆平均反应时间低于倒序记忆，平均正确率高于倒序记忆，两组差异无统计学意义(

=0.402

=0.696)。倒序任务诱发的双侧背外侧前额叶HbO

相对浓度高于正序。数字正序、倒序任务经单样本

检验，大脑激活模式显示编码期、检索期显著激活了大脑双侧的背外侧前额叶；两个任务相比，倒序任务右脑背外侧前额叶的激活更强；两个任务在维持期脑区激活均明显下降(

0.05)。

结论

功能近红外光谱技术能够实时监测脑活动，倒序任务比正序任务激活更多的脑区，双侧的背外侧前额叶共同参与完成信息编码、检索信息处理。

Abstract

Objective

To study the neurological mechanism of working memory in healthy young people by functional near infrared spectroscopy (fNIRS).

Methods

Twenty-three health teachers and students were recruited from our university

and they were 10 males and 13 females

and at an age of 20~24 (22.48±1.24) years. fNIRS was applied on them to collect the data of digital positive and reverse order memories

and the data were analyzed by the software of LAB_NIRS. Brain activation and relative content of HbO

in prefrontal cortex during encoding

maintaining and retrieval of digital memory was discussed respectively.

Results

For positive order memory

the average response time was shorter

and the average correct rate was higher than those of reverse order memory

though no statistical differences between the 2 tasks (

=0.402

=0.696). The relative content of HbO

in bilateral dorsolateral prefrontal lobes induced by inversion task was obviously higher than that induced by positive sequence. After the single-sample

-test of digital positive and reverse task

the brain activation pattern showed that the dorsolateral prefrontal lobes of both sides of the brain were

remarkably activated during the coding period and retrieval period; The activation of the dorsolateral prefrontal lobe was stronger in the digital reverse task than in the digital positive task; The activation in brain areas were significantly decreased in both tasks during maintenance (

0.05).

Conclusion

fNIRS can monitor brain activity in real time. Reverse sequence task activates more brain areas than positive sequence task

and both dorsolateral and prefrontal lobes participate in the completion of information coding and retrieval processing.

关键词

Keywords

references

张世娟, 卢洁, 王晓怡, 等.正常老年人数字记忆功能的磁共振成像[J].中国老年学杂志, 2011, 31(3): 384-386. DOI:10.3969/j.issn.1005-9202.2011.03.007.

ZHANG S J, LU J, WANG X Y, et al . Functional MRI study of digital working memory in the healthy old people[J ] . Chin J Gerontol, 2011, 31(3): 384-386. DOI:10.3969/j.issn.1005-9202.2011.03.007.

吴永明, 柏林, 张增强, 等.正常人长时数字记忆信息提取的神经基础的功能磁共振研究[J].生理学报, 2011, 63(4): 319-324. DOI:10.13294/j.aps.2011.04.006.

WU Y M, BAI L, ZHANG Z Q, et al . A study on the neuronal mechanism of retrieval of long-term digital memory in human by functional magnetic resonance imaging[J ] . Acta Physiol Sin, 2011, 63(4): 319-324. DOI:10.13294/j.aps.2011.04.006.

OGAWA Y, KOTANI K, JIMBO Y. Relationship between working memory performance and neural activation measured using near-infrared spectroscopy[J]. Brain Behav, 2014, 4(4): 544-551. DOI:10.1002/brb3.238.

SHEN J, ZHANG G, YAO L, et al . Real-time fMRI training-induced changes in regional connectivity mediating verbal working memory behavioral performance[J ] . Neuroscience, 2015, 289: 144-152. DOI:10.1016/j.neuroscience.2014.12.071.

WIJEAKUMAR S, HUPPERT T J, MAGNOTTA V A, et al . Validating an image-based fNIRS approach with fMRI and a working memory task[J ] . Neuroimage, 2017, 147: 204-218. DOI:10.1016/j.neuroimage.2016.12.007.

BASSO MORO S, CUTINI S, URSINI M L, et al . Prefrontal cortex activation during story encoding/retrieval: a multi-channel functional near-infrared spectroscopy study[J ] . Front Hum Neurosci, 2013, 7: 925. DOI:10.3389/fnhum.2013.00925.

张静娜, 王莉, 张晔, 等.基于功能近红外光谱技术的镜像运动脑激活特征的初步研究[J].第三军医大学学报, 2018, 40(18): 1682-1687. DOI:10.16016/j.1000-5404.201804010.

ZHANG J N, WANG L, ZHANG Y, et al . Brain activation characteristics during mirror movements in healthy subjects: findings by functional near-infrared spectroscopy[J ] . J Third Mil Med Univ, 2018, 40(18): 1682-1687. DOI:10.16016/j.1000-5404.201804010.

FERRARI M, QUARESIMA V. A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application[J]. Neuroimage, 2012, 63(2): 921-935. DOI:10.1016/j.neuroimage.2012.03.049.

TIAN F H, YENNU A, SMITH-OSBORNE A, et al . Prefrontal responses to digit span memory phases in patients with post-traumatic stress disorder (PTSD): a functional near infrared spectroscopy study[J ] . Neuroimage Clin, 2014, 4: 808-819. DOI:10.1016/j.nicl.2014.05.005.

BOTDORF M, RIGGINS T. When less is more: Thinner fronto-parietal cortices are associated with better forward digit span performance during early childhood[J]. Neuropsychologia, 2018, 121: 11-18. DOI:10.1016/j.neuropsychologia.2018.10.020.

SIDHU M K, STRETTON J, WINSTON G P, et al . A functional magnetic resonance imaging study mapping the episodic memory encoding network in temporal lobe epilepsy[J ] . Brain, 2013, 136(Pt 6): 1868-1888. DOI:10.1093/brain/awt099.

KHARITONOVA M, WINTER W, SHERIDAN M A. As working memory grows: A developmental account of neural bases of working memory capacity in 5- to 8-year old children and adults[J]. J Cogn Neurosci, 2015, 27(9): 1775-1788. DOI:10.1162/jocn_a_00824.

SCHAEFFER J D, YENNU A S, GANDY K C, et al . An fNIRS investigation of associative recognition in the prefrontal cortex with a rapid event-related design[J ] . J Neurosci Methods, 2014, 235: 308-315. DOI:10.1016/j.jneumeth.2014.07.011.

BOAS D A, ELWELL C E, FERRARI M, et al . Twenty years of functional near-infrared spectroscopy: introduction for the special issue[J ] . Neuroimage, 2014, 85(Pt 1): 1-5. DOI:10.1016/j.neuroimage.2013.11.033.

JAHANI S, FANTANA A L, HARPER D, et al . fNIRS can robustly measure brain activity during memory encoding and retrieval in healthy subjects[J ] . Sci Rep, 2017, 7(1): 9533. DOI:10.1038/s41598-017-09868-w.

MCCARTHY G, PUCE A, CONSTABLE R T, et al . Activation of human prefrontal cortex during spatial and nonspatial working memory tasks measured by functional MRI[J ] . Cereb Cortex, 1996, 6(4): 600-611. DOI:10.1093/cercor/6.4.600.

D'ESPOSITO M, AGUIRRE G K, ZARAHN E, et al . Functional MRI studies of spatial and nonspatial working memory[J ] . Brain Res Cogn Brain Res, 1998, 7(1): 1-13.

LUNDSTROM B N, INGVAR M, PETERSSON K M. The role of precuneus and left inferior frontal cortex during source memory episodic retrieval[J]. Neuroimage, 2005, 27(4): 824-834. DOI:10.1016/j.neuroimage.2005.05.008.

SALA J B, RÄMÄP, COURTNEY S M. Functional topography of a distributed neural system for spatial and nonspatial information maintenance in working memory[J]. Neuropsychologia, 2003, 41(3): 341-356.

MCKENDRICK R, MEHTA R, AYAZ H, et al . Prefrontal hemodynamics of physical activity and environmental complexity during cognitive work[J ] . Hum Factors, 2017, 59(1): 147-162. DOI:10.1177/0018720816675053.

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