Analysis of clinical trials carried out by U.S. Army Medical Research and Materiel Command based on ClinicalTrials.gov data

Shaoduo YAN; Yuhua ZHANG; Hui ZHAO; Xiangzhi JIA; Hong ZHANG

doi:10.16016/j.1000-5404.201904184

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Analysis of clinical trials carried out by U.S. Army Medical Research and Materiel Command based on ClinicalTrials.gov data

Military Medicine | 更新时间：2026-01-09

- Analysis of clinical trials carried out by U.S. Army Medical Research and Materiel Command based on ClinicalTrials.gov data
- Journal of Third Military Medical University Vol. 41, Issue 18, Pages: 1707-1711(2019)
- 作者机构：
  
  1.100850 北京，军事科学院军事医学研究院卫生勤务与血液研究所
  2.100012 北京，中国医科大学北京航空总医院口腔科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201904184
  CLC： R195;R82
- Received：20 April 2019，
  
  Revised：2019-07-07，
  
  Published：30 September 2019
- 稿件说明：
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Shaoduo YAN, Yuhua ZHANG, Hui ZHAO, et al. Analysis of clinical trials carried out by U.S. Army Medical Research and Materiel Command based on ClinicalTrials.gov data[J]. Journal of Third Military Medical University, 2019, 41(18): 1707-1711.
DOI：

Shaoduo YAN, Yuhua ZHANG, Hui ZHAO, et al. Analysis of clinical trials carried out by U.S. Army Medical Research and Materiel Command based on ClinicalTrials.gov data[J]. Journal of Third Military Medical University, 2019, 41(18): 1707-1711. DOI： 10.16016/j.1000-5404.201904184.

摘要

目的

分析美国陆军医学研究与物资部(U.S. Army Medical Research and Materiel Command，USAMRMC)临床试验特点，了解美国军队军事医学研究的主要动向。

方法

通过ClinicalTrials.gov数据库检索USAMRMC发起或参与完成的临床试验，从主题词、研究内容、进展状态、临床分期、任务分配及地域分布等方面对临床试验项目进行统计和分析。

结果

USAMRMC主要关注于感染性疾病、创伤及神经系统疾病的临床试验，并在上述疾病的疫苗、药物和医疗器械研发中投入大量研究力量。其主导或参与的临床试验中约57.7%已完成并公布研究结果，77.9%在美国本土组织开展，43.1%由美国军队医学机构直接参与。

结论

USAMRMC主要依托美国本土力量，通过高效的军地协作机制，在战场传染病防治、战伤救治等的基础和临床研究方面开展了大量工作；启示我国军事医学研究要高度重视地域性疾病防治，强化关键核心技术的协同创新。

Abstract

Objective

To analyze the clinical trials carried out by the U.S. Army Medical Research and Materiel Command (USAMRMC) to understand the general trends of US military medical researches.

Methods

We retrieved the data of the clinical researches sponsored or participated by the USAMRMC from ClinicalTrials.gov and analyzed the data in terms of the subject words

research contents

progress

clinical stages

task allocation and geographical distribution of the clinical registers.

Results

The USAMRMC focuses on researches of infectious diseases

trauma and nervous system diseases

and invested heavily on the development of vaccines

drugs and medical equipment. About 57.7% of the clinical researches sponsored or participated by the USAMRMC have been completed and the results have been published; 77.9% of the studies were carried out by the local institutions in the USA

and the military medical institutions participated directly in 43.1% of the studies.

Conclusion

Relying on the local institutions and efficient military-civilian cooperations

the USAMRMC has carried out considerable work in pre-clinical and clinical studies. The practice of the USAMRMC suggests the importance of studies for prevention and treatment of regional diseases and of the collaborative innovation of key technologies between the civilian and military institutions.

关键词

Keywords

references

ZUABI N, PATEL B, LANGDORF M I. U.S. food and drug administration: review for the emergency physician of approval process and limitations[J]. West J Emerg Med, 2016, 17(6): 741-746. DOI:10.5811/westjem.2016.8.31197.

晏小勇, 陈永法.美国临床试验注册与结果公开制度研究[J].中国新药杂志, 2011, 20(7): 577-581.

YAN X Y, CHEN Y F. The US clinical trial registration and result disclosure[J]. Chin J New Drugs, 2011, 20(7): 577-581.

李昕雪, 韩梅, 王禹毅, 等.临床试验的国际注册及在美国临床试验注册平台注册的意义与方法[J].中医杂志, 2013, 54(19): 1640-1643.

LI X X, HAN M, WANG Y Y, et al . Significance and method of international registration of Clinical Trials and Registration of Clinical Trials Platform in the US[J ] . J Tradit Chin Med, 2013, 54(19): 1640-1643.

张音, 刁天喜.美陆军医学研究与卫生物资部设置及新研究领域[J].人民军医, 2009, 52(11): 729-730.

ZHANG Y, DIAO T X. New research areas in the U.S. army medical research and materiel command[J]. People Mil Surg, 2009, 52(11): 729-730.

李哲, 李长芹, 李超, 等.美国陆军医学研究与卫生物资部高级研发计划进展情况简介[J].人民军医, 2019, 62(1): 37-40.

LI Z, LI C Q, LI C, et al . The Introduction of advanced research and development program of the U.S. Army Medical Research and Materiel Command[J ] . People Mil Surg, 2019, 62(1): 37-40.

张音.美陆军医学研究与卫生物资部的科研管理体制[J].人民军医, 2010, 53(1): 17-18.

ZHANG Y. Research management system of the U.S. Army Medical Research and Materiel Command[J]. People Mil Surg, 2010, 53(1): 17-18.

于河, 刘建平.国际临床试验注册概述[J].中西医结合学报, 2007, 5(3): 234-242.

YU H, LIU J P. A review of international clinical trial registration[J]. J Chin Integr Med, 2007, 5(3): 234-242.

杨莉, 田丽娟, 林琳.药物临床试验数据公开制度研究及启示[J].中国新药杂志, 2017, 26(9): 990-998.

YANG L, TIAN L J, LIN L. Research and enlightenment on the drug clinical trial transparency system[J]. Chin J New Drugs, 2017, 26(9): 990-998.

[U.S. National Library of Medicine. ClinicalTrials.gov[EB/OL ] . [2019-02-28 ] . https://www.clinicaltrials.gov/ https://www.clinicaltrials.gov/ .

SHANE R T. The food and drug administration amendments act of 2007: drug safety and health-system pharmacy implications[J]. Am J Health- Syst Pharm, 2009, 66(24_Supplement_7): S2-S3. DOI:10.2146/ajhp090459.

刘传和, 杜永莉.美国临床试验信息及其检索[J].中华医学图书情报杂志, 2004, 13(3): 55-56. DOI: 10.3969/j.issn.1671-3982.2004.03.031.

LIU C H, DU Y L. Clinical trial information of the US on the internet and it's search[J]. Chin J Med Lib Inform Sci, 2004, 13(3): 55-56. DOI: 10.3969/j.issn.1671-3982.2004.03.031.

ZARIN D A, TSE T, WILLIAMS R J, et al . Trial reporting in Clinical Trials.gov—the final rule[J ] . N Engl J Med, 2016, 375(20): 1998-2004. DOI:10.1056/NEJMsr1611785.

TASNEEM A, ABERLE L, ANANTH H, et al . The database for aggregate analysis of ClinicalTrials.gov (AACT) and subsequent regrouping by clinical specialty[J ] . PLoS ONE, 2012, 7(3): e33677. DOI: 10.1371/journal.pone.0033677.

LOWE H J, BARNETT G O. Understanding and using the medical subject headings (MeSH) vocabulary to perform literature[J]. JAMA, 1994, 271(14): 1103-1108. DOI: 10.1001/jama.1994.03510380059038.

BAUMANN N. How to use the medical subject headings (Me SH)[J]. Int J Clin Pract, 2016, 70(2): 171-174. DOI: 10.1111/ijcp.12767.

梁洁.军事力量走出去, 法律保障紧相随[J].法制与社会, 2017(33): 172-173.

LIANG J. When military forces go out, legal safeguards follow closely[J]. Legal Syst Soc, 2017(33): 172-173.

[张建华.提升制造业关键核心技术创新力[EB/OL ] . [2019-01-11 ] . http://www.cssn.cn/ http://www.cssn.cn/ .

[ZHANG J H. Enhancing the innovative ability of key technologies in manufacturing industry[EB/OL ] . [2019-01-11 ] . http://www.cssn.cn/ http://www.cssn.cn/ .

阎少多, 赵慧, 张玉华, 等.美国军队血液保障技术发展情况介绍[J].人民军医, 2019, 62(4): 311-313, 371.

YANS D, ZHAO H, ZHANG Y H, et al . A brief introduction to the development of blood support technology in the U.S. Army[J ] . People Mil Surg, 2019, 62(4): 311-313, 371.

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