Efficacy of non-invasive high frequency oscillatory ventilation as post-extubation respiratory support in preterm neonates: a randomized controlled trial

Huanhuan LI; Xingwang ZHU; Wanjun WANG

doi:10.16016/j.1000-5404.201903161

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Efficacy of non-invasive high frequency oscillatory ventilation as post-extubation respiratory support in preterm neonates: a randomized controlled trial

Clinical Medicine | 更新时间：2026-01-09

- Efficacy of non-invasive high frequency oscillatory ventilation as post-extubation respiratory support in preterm neonates: a randomized controlled trial
- Journal of Third Military Medical University Vol. 41, Issue 17, Pages: 1688-1692(2019)
- 作者机构：
  
  1.400000 重庆，九龙坡区人民医院新生儿科
  2.400014 重庆，重庆医科大学附属儿童医院新生儿诊疗中心
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201903161
  CLC： R181.32;R454.4;R722.6
- Received：20 March 2019，
  
  Revised：2019-06-13，
  
  Published：15 September 2019
- 稿件说明：
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Huanhuan LI, Xingwang ZHU, Wanjun WANG. Efficacy of non-invasive high frequency oscillatory ventilation as post-extubation respiratory support in preterm neonates: a randomized controlled trial[J]. Journal of Third Military Medical University, 2019, 41(17): 1688-1692.
DOI：

Huanhuan LI, Xingwang ZHU, Wanjun WANG. Efficacy of non-invasive high frequency oscillatory ventilation as post-extubation respiratory support in preterm neonates: a randomized controlled trial[J]. Journal of Third Military Medical University, 2019, 41(17): 1688-1692. DOI： 10.16016/j.1000-5404.201903161.

摘要

目的

比较无创高频振荡通气(noninvasive high-frequency oscillatory ventilation，NHFOV)和经鼻持续气道正压通气(nasal continuous positive airway pressure

NCPAP)作为胎龄26

周~31

周早产儿有创机械通气拔管后无创呼吸支持的疗效。

方法

收集2017年1月至2019年1月九龙坡区人民医院新生儿科和重庆医科大学附属儿童医院新生儿诊疗中心收治的早产儿114例，通过抽取信封法随机分成两组:治疗组接受NHFOV治疗(

=56)；对照组接受NCPAP治疗(

=58例)。主要评价指标是两组早产儿在撤离有创机械通气后7 d内无创通气失败需要再次气管插管的比例，次要评价指标包括无创通气支持时间、住院天数和住院死亡、气胸、校正胎龄36周或离院时支气管肺发育不良(bronchopulmonary dysplasia，BPD)、坏死性小肠结肠炎(necrotizing enterocolitis，NEC)、颅内出血(intracranial hemorrhage，IVH)发生情况。

结果

在撤离有创机械通气后7 d内无创通气失败需要再次气管插管的比例方面，NHFOV组明显低于NCPAP组(14.2%

31.0%，

=0.033)；两组次要评价指标比较差异均无统计学意义。

结论

与NCPAP比较，NHFOV作为早产儿有创机械通气拔管后无创呼吸支持可以提高撤机成功率，减少再次气管插管。

Abstract

Objective

To compare the efficacy of non-invasive high-frequency oscillatory ventilation (NHFOV) with nasal continuous positive airway pressure (NCPAP) in preterm infants aged 26

~31

weeks as post-extubation respiratory support.

Methods

A total of 114 infants admitted to Department of Neonatology

Jiulongpo District People's Hospital and Diagnosis and Treatment Center for Neonates of Children's Hospital of Chongqing Medical University during January 2017 to January 2019 were recruited

and randomized to NCPAP gr

oup (

=58

control) and NHFOV group (

=56) by envelope extraction. The primary outcomes were treatment failure and need for re-intubation within 7 d after extubation. Secondary outcomes included duration of noninvasive ventilation

length of hospitalization

mortality

and incidences of pneumothorax

bronchopulmonary dysplasia (BPD) at 36 weeks of postmenstrual age or discharge

intracranial hemorrhage (IVH) and necrotizing enterocolitis (NEC).

Results

The rate of treatment failure and need for re-intubation within 7 d after extubation was significantly lower in the NHFOV group than the NCPAP group (14.2%

31.0%

=0.033). There were no statistically differences in all other secondary outcomes between the 2 groups.

Conclusion

NHFOV can improve the success rate of weaning and reduce the need for re-intubation as compared with NCPAP in preterm infants after extubation.

关键词

Keywords

references

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