Efficacy and safety of transurethral laser versus transurethral resection for non-muscle invasive bladder urothelial carcinoma: a meta-analysis

Guanqiang TIAN; Liang CHENG; Zhihao ZHOU; Yanlin CHEN; Chang LIANG; Yusheng LEI; Tingbo FU; Xirong ZHANG; Peihe LIANG

doi:10.16016/j.1000-5404.201901104

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Efficacy and safety of transurethral laser versus transurethral resection for non-muscle invasive bladder urothelial carcinoma: a meta-analysis

Public Health and Preventive Medicine | 更新时间：2026-01-09

- Efficacy and safety of transurethral laser versus transurethral resection for non-muscle invasive bladder urothelial carcinoma: a meta-analysis
- Journal of Third Military Medical University Vol. 41, Issue 14, Pages: 1387-1396(2019)
- 作者机构：
  
  400010 重庆，重庆医科大学附属第二医院泌尿外科
- 作者简介：
- 基金信息：
  
  the Key Project of Medical Science Research of Chongqing Health Bureau(2011-1-054);the Basic Science and Frontier Technology Research Project of Chongqing(CSTC2017jcyjAX0435);the Fourth-Batch Young and Middle-aged High-end Medical Talents Support Program of Chongqing
- DOI：10.16016/j.1000-5404.201901104
  CLC： R699.5; R730.56; R737.14
- Received：12 January 2019，
  
  Revised：2019-03-15，
  
  Published：30 July 2019
- 稿件说明：
移动端阅览
Guanqiang TIAN, Liang CHENG, Zhihao ZHOU, et al. Efficacy and safety of transurethral laser versus transurethral resection for non-muscle invasive bladder urothelial carcinoma: a meta-analysis[J]. Journal of Third Military Medical University, 2019, 41(14): 1387-1396.
DOI：

Guanqiang TIAN, Liang CHENG, Zhihao ZHOU, et al. Efficacy and safety of transurethral laser versus transurethral resection for non-muscle invasive bladder urothelial carcinoma: a meta-analysis[J]. Journal of Third Military Medical University, 2019, 41(14): 1387-1396. DOI： 10.16016/j.1000-5404.201901104.

摘要

目的

对比分析经尿道激光与经尿道电切手术对非肌层浸润性膀胱尿路上皮癌(non-muscle invasive bladder cancer

NMIBC)的疗效及安全性。

方法

在PubMed、Cochrane图书馆、Medline、Embase、Web of science、社会科学引文索引、中国期刊网全文数据库(CNKI)、中国生物医学文献数据库、维普医学数据库、万方数据库中，检索NMIBC使用经尿道激光与经尿道电切手术治疗的随机对照研究、半随机对照研究(队列研究和病例对照研究)文献，并使用RevMan 5.3软件对数据进行荟萃分析。

结果

共纳入16篇文献，病例2 570例。对比结果如下：手术时间(MD=-0.70；95%

: -2.78~1.38；

=0.51)及术后尿道狭窄发生率(

=0.70；95%

: 0.24~2.06；

=0.52)差异无统计学意义；术中闭孔神经反射(

=0.05；95%

:0.02~0.10；

0.001)、膀胱穿孔发生率(

=0.11；95%

: 0.04~0.29；

0.001)、术后导尿时间(

= -1.08；95%

:-1.46~-0.71；

0.001)、住院时间(MD= -1.00；95%

: -1.66~-0.34；

=0.003)、膀胱冲洗(

=0.21；95%

: 0.13~0.35；

0.001)、12个月复发率(

=0.67；95%

: 0.48~0.93；

=0.02)及24个月复发率(

=0.60；95%

:0.41~0.86；

=0.005)上激光优于电切。

结论

经尿道激光手术治疗NMIBC术中并发症(闭孔神经反射、膀胱穿孔)发生率、术后复发率低，恢复较快，较经尿道电切术具有一定优势。

Abstract

Objective

To compare the safety and efficacy of transurethral laser and transurethral resection for treatment of non-muscle invasive bladder cancer (NMIBC).

Methods

Randomized controlled trials

cohort studies and case-control studies comparing transurethral laser and transurethral resection of NMIBC were retrieved from PubMed

Medline

Embase

Cochrane Library

Web of Science

Social Science Citation Index

China Journal Full-text Database (CNKI)

Chinese Biomedical Literature Database and VIP medical database. RevMan 5.3 software was used for meta-analysis of the data extracted from the eligible studies.

Results

We retrieved 16 eligible studies involving a total of 2 570 patients from the databases. Meta-analysis of the data from these studies showed no significant difference between the 2 surgical modalities in terms of the operation time (

=-0.70

95%

: -2.78~1.38

=0.51) or the occurrence of postoperative urethral stricture (

=0.70

95%

: 0.24~2.06

=0.52). Compared with transurethral resection

transurethral laser surgery was associated with significantly lower incidences of intraoperative obturator nerve reflex (

=0.05

95%

: 0.02~0.10;

0.001) and bladder perforation (

=0.11

95%

: 0.04~0.29

0.001)

shorter postoperative catheterization time (

=-1.08

95%

: -1.46~-0.71

0.001) and length of hospital stay (

=0.05

95%

: 0.02~0.10

0.001)

and lower rates of bladder irrigation (

=0.21

95%

: 0.13~0.35

0.001) and postoperative recurrence at 12 months (

=0.67

95%

: 0.48~0.93

=0.02) and 24 months (

=0.60

95%

: 0.41~0.86

=0.005).

Conclusion

Transurethral laser surgery for NMIBC

as compared with transurethral resection

is associated with lower incidences of intraoperative complications (obsessive nerve reflex and bladder perforation)

a lower postoperative recurrence rate

and faster postoperative recovery.

关键词

Keywords

references

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