Application value of <sup>99m</sup>Tc-HTOC in diagnosis and staging of neuroblastoma in children

Yalan XIONG; Gengbiao YUAN; Chengxi ZHENG; Maohua RAO

doi:10.16016/j.1000-5404.201812134

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Application value of ^99mTc-HTOC in diagnosis and staging of neuroblastoma in children

Clinical Medicine | 更新时间：2026-01-09

- Application value of ^99mTc-HTOC in diagnosis and staging of neuroblastoma in children
- Journal of Third Military Medical University Vol. 41, Issue 13, Pages: 1275-1280(2019)
- 作者机构：
  
  400010 重庆，重庆医科大学附属第二医院核医学科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201812134
  CLC： R739.4;R814.42;R981
- Received：16 December 2018，
  
  Revised：2019-01-07，
  
  Published：15 July 2019
- 稿件说明：
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Yalan XIONG, Gengbiao YUAN, Chengxi ZHENG, et al. Application value of ^99mTc-HTOC in diagnosis and staging of neuroblastoma in children[J]. Journal of Third Military Medical University, 2019, 41(13): 1275-1280.
DOI：

Yalan XIONG, Gengbiao YUAN, Chengxi ZHENG, et al. Application value of ^99mTc-HTOC in diagnosis and staging of neuroblastoma in children[J]. Journal of Third Military Medical University, 2019, 41(13): 1275-1280. DOI： 10.16016/j.1000-5404.201812134.

摘要

目的

探讨全身奥曲肽显像在儿童神经母细胞瘤(neuroblastoma，NB)诊断及分期中的应用价值。

方法

对本院2016年3月至2018年3月接诊的32例临床疑似NB并至少接受了一项传统影像学检查[超声、计算机断层扫描(computed tomography

CT)及核磁共振成像(magnetic resonance imaging

MRI)

]

的患儿进行全身

99m

Tc-奥曲肽显像(

99m

Technetium-Hydrazinonicotinyl- Tyr 3-Octreotide，

99m

Tc-HTOC)检查，结果由两位主治或主任医师进行判定，参照标准为组织病理学、传统影像学及临床随访结果相结合。

结果

99m

Tc-HTOC显像诊断灵敏度96.7%(29/30例)，特异度50%(1/2例)，阳性预测值96.7%(29/30例)，阴性预测值50%(1/2例)，诊断符合率达93.8%(30/32例)。有3例(10%)患儿行

99m

Tc-HTOC显像后改变了初始分期，其中1例患儿从ⅡA期上升到Ⅳ期，其余2例患儿从Ⅲ期上升到Ⅳ期。

结论

99m

Tc-HTOC显像提高了NB初始分期的准确性，可应用于儿童NB的诊断及分期。

Abstract

Objective

To investigate the application value of

99m

technetium-hydrazinonicotinyl-tyr 3-octreotide (

99m

Tc-HTOC) imaging in the diagnosis and staging of neuroblastoma (NB) in children.

Methods

99m

Tc-HTOC scintigraphy was performed on 32 NB suspected children who received at least 1 conventional imaging examination [ultrasound examination

computed tomography (CT)

or magnetic resonance imaging (MRI)

]

from March 2016 to March 2018 in our hospital. Images were evaluated by 2 experienced nuclear medicine physicians or archiaters. The combination of the results of pathological examination

traditional imaging examination and clinical follow-up wer

e reference standards.

Results

The sensitivity of

99m

Tc-HTOC imaging was 96.7% (29/30)

specificity was 50% (1/2)

positive predictive value was 96.7% (29/30)

negative predictive value was 50% (1/2) and diagnostic coincidence rate was 93.8% (30/32). The initial stage was changed in 3 patients (10%) after the

99m

Tc-HTOC imaging. One of the patients was increased from stage ⅡA to stage Ⅳ

and the remaining 2 patients were increased from stage Ⅲ to stage Ⅳ.

Conclusion

99m

Tc-HTOC imaging improves the accuracy of NB initial staging

and can be used in the diagnosis and staging of NB in children.

关键词

Keywords

references

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⁰

Application value of 99mTc-HTOC in diagnosis and staging of neuroblastoma in children

DOI：10.16016/j.1000-5404.201812134

摘要

Abstract

关键词

Keywords

references

Application value of ^99mTc-HTOC in diagnosis and staging of neuroblastoma in children