Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents

Tong WU; Liuyi RAN; Jiajia JIN; Suya WANG; Wei LIU; Ming AI; Jianmei CHEN; LI KUANG

doi:10.16016/j.1000-5404.201811215

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Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents

Basic Medicine | 更新时间：2026-01-09

- Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents
- Journal of Third Military Medical University Vol. 41, Issue 11, Pages: 1065-1069(2019)
- 作者机构：
  
  1.401331 重庆，重庆医科大学附属大学城医院心理卫生中心
  2.400016 重庆，重庆医科大学附属第一医院心理卫生中心
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(81671360)
- DOI：10.16016/j.1000-5404.201811215
  CLC： R181.23;R394.1;R749.91
- Received：29 November 2018，
  
  Revised：2019-01-22，
  
  Published：15 June 2019
- 稿件说明：
移动端阅览
Tong WU, Liuyi RAN, Jiajia JIN, et al. Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents[J]. Journal of Third Military Medical University, 2019, 41(11): 1065-1069.
DOI：

Tong WU, Liuyi RAN, Jiajia JIN, et al. Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents[J]. Journal of Third Military Medical University, 2019, 41(11): 1065-1069. DOI： 10.16016/j.1000-5404.201811215.

摘要

目的

探讨脑源性神经营养因子(brain-derived neurotrophic factor，BDNF)基因与神经营养性酪氨酸激酶受体2型(neurotrophic tyrosine kinase receptor type 2，NTRK2)基因交互作用与青年自杀未遂行为的关系。

方法

使用IMLDR

多重SNP分型技术对病例组(70例自杀未遂青年人)和对照组(112例健康青年人)的BDNF基因1个多态性位点rs1491851和NTRK2基因3个多态性位点rs1147198、rs11140800、rs1565445进行分型，采用广义多因子降维法(generalized multifactor dimensionality reduction，GMDR)分析基因-基因交互作用。

结果

在病例组与对照组中，BDNF rs1491851、NTRK2 rs1147198、rs11140800、rs1565445基因型频率与等位基因频率的分布差异均无统计学意义(

0.05)。GMDR分析结果显示，BDNF基因与NTRK2基因的2~4阶交互作用，分别为两位点模型(rs1491851、rs1147198)、三位点模型(rs1491851、rs1147198、rs11140800)和四位点模型(rs1491851、rs1147198、rs11140800、rs1565445)。其中四位点模型(rs1491851、rs1147198、rs11140800、rs1565445，测试样本精度为0.632 5，交叉一致性检验为10/10，1 000次置换检验

值为0.032~0.033)为最佳模型。

结论

BDNF基因与NTRK2基因存在交互作用，可能与青年自杀未遂行为相关。

Abstract

Objective

To investigate the association of the interaction between brain-derived neurotrophic factor (BDNF) gene and neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene with suicide attempt in adolescents.

Methods

One single nucleotide polymorphism (SNP) of BDNF gene (rs1491851) and 3 SNPs of NTRK2 (rs1147198

rs11140800

rs1565445) were tested by IMLDR

multiplex SNP typing in 70 suicide attempters (15~24 years old) and 111 healthy young individuals (control). Analysis on gene-gene interaction was conducted by generalized multifactor dimensionality reduction (GMDR).

Results

No significant differences were found in genotype frequencies and allele frequencies between the attempters and controls at 4 SNPs (BDNF rs1491851

and NTRK2 rs1147198

rs1140800

rs1565445)(

0.05). GMDR analysis indicated the interactions between BDNF gene and NTRK2 gene included a two-locus combination (rs1491851

rs1147198)

a three-locus combination (rs1491851

rs1147198

rs11140800) and four-locus combination (rs1491851

rs1147198

rs11140800

rs1565445). The four-locus combination was identified as the best model (Bal. Acc. CV test: 0.632 5

CVC consistency: 10/10

permutation test:

=0.032~0.033).

Conclusion

There are interactions between BDNF gene and NTRK2 gene

which may be associated with suicide attempt in adolescents.

关键词

Keywords

references

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