Outcomes of pregnancy-associated breast cancer: a Meta-analysis

Hao TANG; Jinsong WANG; Deyang GUO; Lei CHEN; Jian ZHANG; Zheng YU

doi:10.16016/j.1000-5404.201810028

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Outcomes of pregnancy-associated breast cancer: a Meta-analysis

Public Health and Preventive Medicine | 更新时间：2026-01-09

- Outcomes of pregnancy-associated breast cancer: a Meta-analysis
- Journal of Third Military Medical University Vol. 41, Issue 6, Pages: 624-630, 封三(2019)
- 作者机构：
  
  402160 重庆，重庆医科大学附属永川医院普外一科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201810028
  CLC： R181.23;R714.25;R737.9
- Received：08 October 2018，
  
  Revised：2018-11-27，
  
  Published：30 March 2019
- 稿件说明：
移动端阅览
Hao TANG, Jinsong WANG, Deyang GUO, et al. Outcomes of pregnancy-associated breast cancer: a Meta-analysis[J]. Journal of Third Military Medical University, 2019, 41(6): 624-630, 封三.
DOI：

Hao TANG, Jinsong WANG, Deyang GUO, et al. Outcomes of pregnancy-associated breast cancer: a Meta-analysis[J]. Journal of Third Military Medical University, 2019, 41(6): 624-630, 封三. DOI： 10.16016/j.1000-5404.201810028.

摘要

目的

比较妊娠相关乳腺癌(pregnancy associated breast cancer

PABC)和非妊娠相关乳腺癌(non-pregnancy associated breast cancer，non-PABC)的病死率(case-fatality rate，CFR)和复发率(relapse rate

RR)差异，以及探究造成差异的可能因素以期改善患者的预后。

方法

检索MEDLINE(PubMed)数据库、中国知网(CNKI)数据库、万方数据库、维普数据库，收集在怀孕期间或之后1年内诊断乳腺癌患者的研究文献，并使用纽卡斯尔-渥太华量表(Newcastle-Ottawa Scale，NOS)来进行文献质量评价，数据分析采用RevMan5.3软件，计算合并危险比值比(odds ratio，

)及95%可信区间(

)并对发表偏倚进行评估。

结果

23篇文献纳入病死率对比的Meta分析(PABC组1 999例，non-PABC组13 271例)结果显示：与non-PABC组相比，PABC组的病死风险更高(

=1.46，95%

：1.31-1.63；

=0.40，

=5%)。5篇文献纳入复发率对比的Meta分析(PABC组188例，non-PABC组493例)结果显示：与non-PABC组相比，PABC组的复发风险也更高(

=2.10，9

：1.45-3.04；

=0.30，

=18%)。漏斗图均提示不存在发表偏倚。

结论

PABC患者相对non-PABC患者的预后更差。

Abstract

Objective

To compare the case-fatality rate (CFR) and relapse rate (RR) between patients with pregnancy-associated breast cancer (PABC) and non-PABC and explore the possible factors contributing to such differences.

Methods

We searched the online databases including PubMed

CNKI

Wanfang

and VIP for case-control or cohort studies describing the outcomes of patients with breast cancer diagnosed during or within 1 year after pregnancy. The Newcastle-Ottawa Scale (NOS) was used for literature quality evaluation. The odds ratio (

) and 95% confidence interval (95%

) were calculated using RevMan5.3

and the publication bias of the retrieved articles was evaluated.

Results

We retrieved 23 articles that compared the CFR between patients with PABC (

=1 999) and non-PABC (

=13 271). The results of meta-analysis showed that the patients with PABC had a significantly higher CFR than those with non-PABC (

=1.46

95%

: 1.31-1.63;

=0.40

=5%). Meta-analysis of 5 articles that compared the RR between patients with PABC (

=188) and non-PABC (

=493) showed that the patients with PABC had a significantly higher RR than those with non-PABC (

=2.10

95%

: 1.45-3.04;

=0.30

=18%). The funnel plots indicated no publication bias in all the articles included in this analysis.

Conclusion

The patients with PABC have a poorer prognosis than those with non-PABC.

关键词

Keywords

references

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