Efficacy and safety of drug-eluting balloon dilatation for coronary bifurcation disease in diabetic patients

Yuou XIA; Yaoming SONG

doi:10.16016/j.1000-5404.201808097

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Efficacy and safety of drug-eluting balloon dilatation for coronary bifurcation disease in diabetic patients

Clinical Medicine | 更新时间：2026-01-09

- Efficacy and safety of drug-eluting balloon dilatation for coronary bifurcation disease in diabetic patients
- Journal of Third Military Medical University Vol. 40, Issue 24, Pages: 2260-2265(2018)
- 作者机构：
  
  400037 重庆, 陆军军医大学(第三军医大学)第二附属医院心血管内科, 全军心血管病研究所
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201808097
  CLC： R181.32;R541.405;R587.1
- Received：14 August 2018，
  
  Revised：2018-10-22，
  
  Published：30 December 2018
- 稿件说明：
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Yuou XIA, Yaoming SONG. Efficacy and safety of drug-eluting balloon dilatation for coronary bifurcation disease in diabetic patients[J]. Journal of Third Military Medical University, 2018, 40(24): 2260-2265.
DOI：

Yuou XIA, Yaoming SONG. Efficacy and safety of drug-eluting balloon dilatation for coronary bifurcation disease in diabetic patients[J]. Journal of Third Military Medical University, 2018, 40(24): 2260-2265. DOI： 10.16016/j.1000-5404.201808097.

摘要

目的

观察冠状动脉分叉病变合并糖尿病患者接受紫杉醇药物洗脱球囊(drug eluted balloon

DEB)扩张术后的疗效。

方法

本研究纳入了2016年5月-2017年7月于陆军军医大学(第三军医大学)第二附属医院心血管内科诊断为冠状动脉分叉病变，分支血管行DEB扩张术患者共105例。按照是否合并糖尿病分组，两组患者术后随访第6、9、12个月主要不良心血管事件(包括心绞痛、急性心肌梗死、靶器官血运重建及心源性死亡)的发生情况；术后第12个月复查选择性冠状动脉造影。

结果

两组患者在性别、年龄及冠心病危险因素等临床资料差异均无统计学意义(

0.05)。多因素COX回归模型分析表明：经过1年随访，合并糖尿病与发生主要不良心血管事件(major adverse cardiac events，MACE)之间差异无统计学意义(

=0.235)。两组患者复查选择性冠状动脉造影出现分支血管狭窄数目差异无统计学意义(

0.05)。

结论

合并糖尿病不会增加冠状动脉分叉病变患者行紫杉醇药物洗脱球囊扩张术后出现主要不良心血管事件和血管再狭窄的发生率，该类患者行紫杉醇药物洗脱球囊扩张术安全有效。

Abstract

Objective

To evaluate the efficacy and safety of paclitaxel drug-eluting balloon (DEB) dilatation for treatment of coronary bifurcation disease in patients with diabetes mellitus.

Methods

This study was conducted among 105 patients with coronary artery bifurcation disease undergoing DEB dilation in our department between May

2016 and July

2017. The patients with and without diabetes were compared for major adverse cardiovascular events (MACE; including angina

acute myocardial infarction

target organ revascularization and cardiogenic death) at 6

9 and 12 months following the intervention. At 12 months after surgery

all the patients underwent selective coronary angiography to detect branch stenosis of the coronary artery.

Results

The patients in the diabetic and non-diabetic groups were comparable for gender

age and risk factors of coronary heart disease. Multivariate COX regression model analysis showed no significant correlation between diabetes and MACE at 1 year after the operation (

=0.235). Selective coronary angiography at 1 year after the operation showed no significant difference in the number of stenotic coronary artery branches between the 2 groups (

0.05).

Conclusion

Diabetes does not increase the risks of MACE or coronary artery branch restenosis after DEB dilatation

which is safe and effective for intervention of coronary artery bifurcation disease in diabetic patients.

关键词

Keywords

references

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