Stem cell transplantation for retinal degeneration: current status and future prospects

Yong LIU

doi:10.16016/j.1000-5404.201807157

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Stem cell transplantation for retinal degeneration: current status and future prospects

更新时间：2026-03-02

- Stem cell transplantation for retinal degeneration: current status and future prospects
- Journal of Third Military Medical University Vol. 41, Issue 3, Pages: 187-191(2019)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院全军眼科中心，视觉损伤与再生修复重庆市重点实验室Department of Ophthalmology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China
- 作者简介：
- 基金信息：
  
  the National Key Research and Development Plan(2016YFC1101103)
- DOI：10.16016/j.1000-5404.201807157
  CLC： R617;R774.1
- Received：21 July 2018，
  
  Published：15 February 2019
- 稿件说明：
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Yong LIU. Stem cell transplantation for retinal degeneration: current status and future prospects[J]. Journal of Third Military Medical University, 2019, 41(3): 187-191.
DOI：

Yong LIU. Stem cell transplantation for retinal degeneration: current status and future prospects[J]. Journal of Third Military Medical University, 2019, 41(3): 187-191. DOI： 10.16016/j.1000-5404.201807157.

摘要

Abstract

Age-related macular degeneration (AMD) and retinitis pigmentosa (RP)

characterized by dysfunction and loss of retinal pigment epithelium (RPE) and photoreceptors and then retinal degeneration

are major causes of blindness. Currently

there is still no curable treatment available. Recent clinical trials showed that stem cell therapy provided a safe and promising efficiency for these retinal diseases. Transplantation of human embryonic stem cells (hESCs) and induced pluripotent stem (iPS) cells have obtained safe outcomes for RPE replacement and achieved certain efficacy in treatment of AMD. Fetal retinal progenitor cells for photoreceptor replacement have also confirmed long-term safety and feasibility in vision repair for RP patients. However

there still exist some challenges in this field

including developing novo transplantation technique

ensuring long-term cellular survival and promoting the integration of transplanted cells into the retina. This article provided an analysis of ongoing studies and challenges ahead in this aspect.

关键词

Keywords

references

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