Nanomaterial fullerenol attenuates liver and kidney impairments and hematological abnormalities in lead-poisoned rats

Yingying ZHA; Jin GE; Chao ZHENG; Xiaowen YU

doi:10.16016/j.1000-5404.201805079

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Nanomaterial fullerenol attenuates liver and kidney impairments and hematological abnormalities in lead-poisoned rats

更新时间：2026-01-09

- Nanomaterial fullerenol attenuates liver and kidney impairments and hematological abnormalities in lead-poisoned rats
- Journal of Third Military Medical University Vol. 40, Issue 21, Pages: 1962-1966,1977(2018)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the National Natural Science Foundation for Young Scholars of China(81601158);the Natural Science Foundation for Young Scholars of Anhui Province(1508085SQC203)
- DOI：10.16016/j.1000-5404.201805079
  CLC：
- Received：15 November 2017，
  
  Published：15 November 2018
- 稿件说明：
移动端阅览
Yingying ZHA, Jin GE, Chao ZHENG, et al. Nanomaterial fullerenol attenuates liver and kidney impairments and hematological abnormalities in lead-poisoned rats[J]. Journal of Third Military Medical University, 2018, 40(21): 1962-1966,1977.
DOI：

Yingying ZHA, Jin GE, Chao ZHENG, et al. Nanomaterial fullerenol attenuates liver and kidney impairments and hematological abnormalities in lead-poisoned rats[J]. Journal of Third Military Medical University, 2018, 40(21): 1962-1966,1977. DOI： 10.16016/j.1000-5404.201805079.

摘要

Abstract

Objective

To investigate the repair effects of nanomaterial fullerenol on the liver and kidney impairments and hematological abnormalities in lead-poisoned rats and explore its possible mechanism.

Methods

Newborn Wistar rats (5±1 g

regardless of sex) were randomly divided into normal control group (

=10

normal feeding)

lead-poisoning model group (

=10

0.2% of lead acetate in drinking water) and fullerenol intervention group (

=10

0.2% of lead acetate in drinking water

intraperitoneal injection of 5 mg/kg fullerenol once every day for 10 d from the age of 3 weeks). When the rats were at 5 weeks old

they were sacrificed

and HE staining was used to observe the pathological changes in the liver and kidney tissues. And the hematological indexes were analyzed using routine blood test. Total nitric oxide (NO) concentration detection kit and Western blotting were employed to measure the concentration of NO and the expression of inducible nitric oxide synthase (iNOS)

respectively.

Results

Fullerenol greatly changed the morphological abnormalities of liver and kidney

including hepatocyte swelling

nuclear conde

nsation and glomerular atrophy. Meanwhile

fullerenol significantly increased the hematological indexes associated with anemia (all

0.05)

such as red blood cell (RBC)

hemoglobin (HGB)

mean corpuscle volume (MCV) and mean corpuscle concentration (MCHC). What's more

compared with the lead-poisoning model group (0.58±0.06)

the expression of iNOS in the brain tissue was significantly reduced in the fullerenol intervention group (0.39±0.05

0.05).

Conclusion

By regulating NO-NOS system

fullerenol repairs the damages caused by lead poisoning

including the morphological abnormalities of the liver and kidneys as well as the important hematological indexes related to anemia.

关键词

Keywords

references

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