Correlation of lipoprotein-associated phospholipase A2 and hemoglobin A1c levels with severity of coronary artery disease in diabetic patients

Yunlong CHEN; Chuan LIU; Xiaoyan LIU; Zhinian GUO; Xiangui WENG; Rong WANG; Jiang WANG

doi:10.16016/j.1000-5404.201803083

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Correlation of lipoprotein-associated phospholipase A2 and hemoglobin A1c levels with severity of coronary artery disease in diabetic patients

Clinical Medicine | 更新时间：2026-01-09

- Correlation of lipoprotein-associated phospholipase A2 and hemoglobin A1c levels with severity of coronary artery disease in diabetic patients
- Journal of Third Military Medical University Vol. 40, Issue 12, Pages: 1136-1141(2018)
- 作者机构：
  
  400037 重庆，陆军军医大学(第三军医大学)第二附属医院心血管内科, 全军心血管病研究所
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201803083
  CLC： R446.11;R543.3;R587.2
- Received：12 March 2018，
  
  Revised：2018-04-03，
  
  Published：2018-01
- 稿件说明：
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Yunlong CHEN, Chuan LIU, Xiaoyan LIU, et al. Correlation of lipoprotein-associated phospholipase A2 and hemoglobin A1c levels with severity of coronary artery disease in diabetic patients[J]. Journal of Third Military Medical University, 2018, 40(12): 1136-1141.
DOI：

Yunlong CHEN, Chuan LIU, Xiaoyan LIU, et al. Correlation of lipoprotein-associated phospholipase A2 and hemoglobin A1c levels with severity of coronary artery disease in diabetic patients[J]. Journal of Third Military Medical University, 2018, 40(12): 1136-1141. DOI： 10.16016/j.1000-5404.201803083.

摘要

目的

探讨脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2，Lp-PLA2)、糖化血红蛋白(HbA1c)水平与糖尿病患者冠脉病变程度的相关性。

方法

选取2017年7月至12月在陆军军医大学(第三军医大学)第二附属医院心血管内科住院患者241例；按冠脉狭窄程度及糖尿病病史分为冠心病组(42例)、糖尿病组(34例)、糖尿病合并冠心病组(127例)、正常对照组(38例)。按左心室射血分素(LVEF)结果分为LVEF＜50%组(91例)和LVEF≥50%(150例)。检测循环Lp-PLA2和HbA1c水平并进行统计学分析。

结果

糖尿病合并冠心病组Lp-PLA2水平显著高于糖尿病组和正常对照组(

0.05)；HbA1c在糖尿病合并冠心病组显著高于冠心病组和正常对照组(

0.05)。多元线性回归分析Lp-PLA2、HbA1c与冠脉狭窄程度(Gensini积分)正相关(

值：0.189、0.138

0.05)。多因素Logistic回归分析Lp-PLA2、HbA1c为冠脉狭窄程度的独立危险因素(

值：1.012、0.097、

0.05)。LVEF＜50%组Lp-PLA2水平显著高于LVEF≥50%组(

0.05)；HbA1c水平两组间比较差异无统计学意义(

0.05)。

结论

糖尿病合并冠心病患者循环Lp-PLA2和HbA1c水平明显升高且与冠状动脉狭窄程度呈正相关，二者联合检测对预测糖尿病患者冠脉病变程度有较好的临床价值。

Abstract

Objective

To explore the correlation of circulating lipoprotein-associated phospholipase A2 (Lp-PLA2) and hemoglobin A1c (HbA1c) levels with the severity of coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM).

Methods

A total of 241 inpatients with suspected coronary artery disease (CHD) admitted in our department between July

2017 and December

2017 were enrolled in this study. According to the findings in coronary angiography

the patients were divided into CHD

T2DM

CHD with T2DM and healthy control groups. The patients were also stratified according to their left ventricular ejection fraction (LVEF) into LVEF < 50% group and LVEF≥50% group. For all the participants

circulating HbA1c level was determined with chemiluminescence detection and Lp-PLA2 level with enzyme-linked immunosorbent assay (ELISA).

Results

Lp-PLA2 level was significantly higher in diabetic patients with CHD than in those with T2DM and the healthy control subjects (

0.05). The diabetic patients with CHD also showed a significantly higher level of HbA1c than those with CHD and the control subjects (

0.05). Multivariate linear regression analysis showed that Lp-PLA2 (

=0.189

0.05) and HbA1c (

=0.138

0.05) levels were both positively correlated with the severity of coronary stenosis (Gensini score). Multivariate logistic regression analysis identified Lp-PLA2 (

=1.012

0.05) and HbA1c (

=0.097

0.05) as independent risk factors for coronary stenosis. The patients with a LVEF

50% had a significantly higher Lp-PLA2 level than those with a LVEF ≥50% (

0.05)

but their HbA1c level did not differ significantly (

0.05).

Conclusion

In diabetic patients with CHD

Lp-PLA2 and HbA1c levels are positively correlated with the severity of coronary artery stenosis

and the combined detection of Lp-PLA2 and HbA1c can be clinically informative for predicting the severity of coronary artery stenosis.

关键词

Keywords

references

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