Expression differences of CD105 in recipient bone marrow stromal cells between patients with good and poor graft function after allogeneic hematopoietic stem cell transplantation

Siheng LIU; Cenxia RAN; Xiaocui YI; Jia LI; Xiangui PENG; Yao LIU

doi:10.16016/j.1000-5404.201803059

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Expression differences of CD105 in recipient bone marrow stromal cells between patients with good and poor graft function after allogeneic hematopoietic stem cell transplantation

更新时间：2026-01-09

- Expression differences of CD105 in recipient bone marrow stromal cells between patients with good and poor graft function after allogeneic hematopoietic stem cell transplantation
- Journal of Third Military Medical University Vol. 40, Issue 17, Pages: 1568-1573(2018)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(81670100);the General Program of National Natural Science Foundation of China(81370594)
- DOI：10.16016/j.1000-5404.201803059
  CLC：
- Received：08 March 2018，
  
  Published：15 September 2018
- 稿件说明：
移动端阅览
Siheng LIU, Cenxia RAN, Xiaocui YI, et al. Expression differences of CD105 in recipient bone marrow stromal cells between patients with good and poor graft function after allogeneic hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2018, 40(17): 1568-1573.
DOI：

Siheng LIU, Cenxia RAN, Xiaocui YI, et al. Expression differences of CD105 in recipient bone marrow stromal cells between patients with good and poor graft function after allogeneic hematopoietic stem cell transplantation[J]. Journal of Third Military Medical University, 2018, 40(17): 1568-1573. DOI： 10.16016/j.1000-5404.201803059.

摘要

Abstract

Objective

To investigate the expression profiles of adhesion molecule-related antigens in bone marrow stromal cells of the recipients with good and poor graft function after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods

A total of 118 patients underwent allo-HSCT in our department in 2016 were recruited in this study. According to the functional status of the graft after allo-HSCT

the recipients were divided into good graft function (GGF) group and poor graft function (PGF) for comparison of age

primary disease

stem cell source

HLA typing

gender matching

ABO blood group matching

bone marrow hyperplasia before transplantation

recurrence rates

and mortality rates. For 28 recipients with PGF and 27 with GGF

the pre-transplant bone marrow biopsy specimens were obtained for immunohistochemical analysis of the adhesion molecules including CD44

CD105

CD29

intercellular adhesion molecule-1 (ICAM-1)

and vascular cell adhesion molecule-1 (VCAM-1).

Results

The recipients with PGF and GGF did not show significant differences in age

primary disease

stem cell source

HLA typing

gender matching

ABO blood group matching or the degree of bone marrow hyperplasia before transplantation (

0.05). Compared with those with GGF

the recipients with PGF had a significantly higher CMV infection rate after transplantation and a significantly lower remission rate before transplantation (

0.05). Cox regression analysis showed that the recipients with PGF following allo-HSCT had a significantly lower survival rate than those with GGF (

0.05

=3.598). The expression levels of CD44

CD29

ICAM-1 and VCAM-1 in recipient bone marrow stromal cells were comparable between the recipients with GGF and PGF (

0.05)

but the recipients with PGF following allo-HSCT had a significantly higher expression level of CD105 in the stromal cells than those with GGF (

0.05).

Conclusion

PGF following allo-HSCT is associated with a significantly decreased survival rate of the recipients. The occurrence of PGF following allo-HSCT is probably linked with an increased expression of CD105 in the bone marrow stromal cells of the recipients before transplantation.

关键词

Keywords

references

王莹樊星王苓异基因造血干细胞移植后死亡原因分析内科理论与实践 2014 9 4 270 273 10.3969/j.issn.1673-6087.2014.04.008 王莹, 樊星, 王苓, 等.异基因造血干细胞移植后死亡原因分析[J].内科理论与实践, 2014, 9(4):270-273. DOI: 10.3969/j.issn.1673-6087.2014.04.008.

WANG Y FAN X WANG L Analysis of the causes of death after allogeneic hematopoietic stem cell transplantation J Intern Med Concepts Pract 2014 9 4 270 273 10.3969/j.issn.1673-6087.2014.04.008 WANG Y, FAN X, WANG L, et al . Analysis of the causes of death after allogeneic hematopoietic stem cell transplantation[J ] . J Intern Med Concepts Pract, 2014, 9(4): 270-273. DOI: 10.3969/j.issn.1673-6087. 2014.04.008.

马俐君胡晓霞周虹间充质干细胞与人脐血CD34 + 细胞共移植对NOD/SCID小鼠造血重建的影响中华血液学杂志 2008 29 10 684 688 10.3321/j.issn:0253-2727.2008.10.009 马俐君, 胡晓霞, 周虹, 等.间充质干细胞与人脐血CD34 + 细胞共移植对NOD/SCID小鼠造血重建的影响[J ] .中华血液学杂志, 2008, 29(10): 684-688. DOI: 10.3321/j.issn:0253-2727.2008.10.009.

MA L J HU X X ZHOU H Study on hematopoiesis reconstitution by co-transplant of human bone marrow mesenchymal stem cells and umbilical cord blood CD34 + cells at different ratios in NOD/SCID mice Chin J Hematol 2008 29 10 684 688 10.3321/j.issn:0253-2727.2008.10.009 MA L J, HU X X, ZHOU H, et al . Study on hematopoiesis reconstitution by co-transplant of human bone marrow mesenchymal stem cells and umbilical cord blood CD34 + cells at different ratios in NOD/SCID mice[J ] . Chin J Hematol, 2008, 29(10): 684-688.DOI: 10.3321/j.issn:0253-2727.2008.10.009.

HAEN S P SCHUMM M FAUL C Poor graft function can be durably and safely improved by CD34 + -selected stem cell boosts after allogeneic unrelated matched or mismatched hematopoietic cell transplantation J Cancer Res Clin Oncol 2015 141 12 2241 2251 10.1007/s00432-015-2027-x HAEN S P, SCHUMM M, FAUL C, et al . Poor graft function can be durably and safely improved by CD34 + -selected stem cell boosts after allogeneic unrelated matched or mismatched hematopoietic cell transplantation[J ] . J Cancer Res Clin Oncol, 2015, 141(12): 2241-2251. DOI: 10.1007/s00432-015-2027-x.

MASOURIDI-LEVRAT S SIMONETTA F CHALANDON Y Immunological basis of bone marrow failure after allogeneic hematopoietic stem cell transplantation Front Immunol 2016 7 4 362 10.3389/fimmu.2016.00362 MASOURIDI-LEVRAT S, SIMONETTA F, CHALANDON Y. Immunological basis of bone marrow failure after allogeneic hematopoietic stem cell transplantation[J]. Front Immunol, 2016, 7(4): 362. DOI: 10.3389/fimmu.2016.00362.

KONG Y WANG Y T HU Y The bone marrow micro environment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function Bone Marrow Transplant 2016 51 2 249 255 10.1038/bmt.2015.229 KONG Y, WANG Y T, HU Y, et al . The bone marrow micro environment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function[J ] . Bone Marrow Transplant, 2016, 51(2): 249-255. DOI: 10.1038/bmt.2015.229.

SNELL M CHAU C HENDRIX D Lack of iso-hemagglutinin production following minor ABO incompatible unrelated HLA mismatched umbilical cord blood transplantation Bone Marrow Transplant 2006 38 2 135 140 10.1038/sj.bmt.1705409 SNELL M, CHAU C, HENDRIX D, et al . Lack of iso-hemagglutinin production following minor ABO incompatible unrelated HLA mismatched umbilical cord blood transplantation[J ] . Bone Marrow Transplant, 2006, 38(2): 135-140. DOI: 10.1038/sj.bmt.1705409.

KONG Y CHANG Y J WANG Y Z Association of an impaired bone marrow microenvironment with secondary poor graft function after allogeneic hematopoietic stem cell transplantation Biol Blood Marrow Transplant 2013 19 10 1465 1473 10.1016/j.bbmt.2013.07.014 KONG Y, CHANG Y J, WANG Y Z, et al . Association of an impaired bone marrow microenvironment with secondary poor graft function after allogeneic hematopoietic stem cell transplantation[J ] . Biol Blood Marrow Transplant, 2013, 19(10): 1465-1473. DOI: 10.1016/j.bbmt.2013.07.014.

STASIA A GHISO A GALAVERNA F CD34 selected cells for the treatment of poor graft function after allogeneic stem cell transplantation Biol Blood Marrow Transplant 2014 20 9 1440 1443 10.1016/j.bbmt.2014.05.016 STASIA A, GHISO A, GALAVERNA F, et al . CD34 selected cells for the treatment of poor graft function after allogeneic stem cell transplantation[J ] . Biol Blood Marrow Transplant, 2014, 20(9): 1440-1443. DOI: 10.1016/j.bbmt.2014.05.016.

李明辉田丁刘聪燕人骨髓间充质干细胞的培养及研究首都医科大学学报 2005 26 2 183 186 10.3969/j.issn.1006-7795.2005.02.023 李明辉, 田丁, 刘聪燕, 等.人骨髓间充质干细胞的培养及研究[J].首都医科大学学报, 2005, 26(2): 183-186.

LI M H TIAN D LIU C Y Culture of human bone marrow mesenchymal stem cells J Capital Med Univ 2005 26 2 183 186 10.3969/j.issn.1006-7795.2005.02.023 LI M H, TIAN D, LIU C Y, et al . Culture of human bone marrow mesenchymal stem cells[J ] . J Capital Med Univ, 2005, 26(2): 183-186.

李梅朱艳华张瑜 CD105的研究现状现代医药卫生 2004 20 21 2255 2256 10.3969/j.issn.1009-5519.2004.21.041 李梅, 朱艳华, 张瑜, 等. CD105的研究现状[J].现代医药卫生, 2004, 20(21): 2255-2256.

LI M ZHU Y H ZHANG Y Research status of CD105 Mod Med Health 2004 20 21 2255 2256 10.3969/j.issn.1009-5519.2004.21.041 LI M, ZHU Y H, ZHANG Y, et al . Research status of CD105[J ] . Mod Med Health, 2004, 20(21): 2255-2256.

常城陈幸华孔佩艳全反式维甲酸对外周血干细胞移植患者骨髓基质细胞黏附分子表达及黏附力的影响中国实验血液学杂志 2006 14 4 768 772 10.3969/j.issn.1009-2137.2006.04.030 常城, 陈幸华, 孔佩艳, 等.全反式维甲酸对外周血干细胞移植患者骨髓基质细胞黏附分子表达及黏附力的影响[J].中国实验血液学杂志, 2006, 14(4): 768-772.

CHANG C CHEN X H KONG P Y In vitro effect of all-trans retinoic acid on cell adhesion molecule expression and adhesion capacity of bone marrow stromal cells in patients received peripheral blood stem cell transplantation J Exp Hematol 2006 14 4 768 772 10.3969/j.issn.1009-2137.2006.04.030 CHANG C, CHEN X H, KONG P Y, et al . In vitro effect of all-trans retinoic acid on cell adhesion molecule expression and adhesion capacity of bone marrow stromal cells in patients received peripheral blood stem cell transplantation[J ] . J Exp Hematol, 2006, 14(4): 768-772.

FONSATTI E DEL VECCHIO L ALTOMONTE M Endoglin: an accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies J Cell Physiol 2001 188 1 1 7 10.1002/jcp.1095 FONSATTI E, DEL VECCHIO L, ALTOMONTE M, et al . Endoglin: an accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies[J ] . J Cell Physiol, 2001, 188(1): 1-7. DOI: 10.1002/jcp.1095.

WANG J M KUMAR S PYE D Breast carcinoma: comparative study of tumor vasculature using two endothelial cell markers J Natl Cancer Inst 1994 86 5 386 388 10.1093/jnci/86.5.386 WANG J M, KUMAR S, PYE D, et al . Breast carcinoma: comparative study of tumor vasculature using two endothelial cell markers[J ] . J Natl Cancer Inst, 1994, 86(5): 386- 388. DOI: 10.1093/jnci/86.5.386.

AKAGI K IKEDA Y SUMIYOSHI Y Estimation of angiogenesis with anti-CD105 immunostaining in the process of colorectal cancer development Surgery 2002 131 1suppl S109 S113 10.1067/msy.2002.119361 AKAGI K, IKEDA Y, SUMIYOSHI Y, et al . Estimation of angiogenesis with anti-CD105 immunostaining in the process of colorectal cancer development[J ] . Surgery, 2002, 131(1suppl): S109-S113. DOI: 10.1067/msy.2002.119361.

王晓宁张梅贺鹏程异基因造血干细胞移植中回输造血干细胞的量和回输时受者白细胞数与疾病预后关系分析中国实验血液学杂志 2013 21 6 1530 1534 10.7534/j.issn.1009-2137.2013.06.031 王晓宁, 张梅, 贺鹏程, 等.异基因造血干细胞移植中回输造血干细胞的量和回输时受者白细胞数与疾病预后关系分析[J].中国实验血液学杂志, 2013, 21(6): 1530-1534. DOI: 10.7534/j.issn.1009-2137.2013.06.031.

WANG X N ZHANG M HE P C Relation of reinfused hematopoietic stem cell volume and recipient's leukocyte count at reinfusion with prognosis of disease in allo-hematopoietic stem cell transplantation J Exp Hematol 2013 21 6 1530 1534 10.7534/j.issn.1009-2137.2013.06.031 WANG X N, ZHANG M, HE P C, et al . Relation of reinfused hematopoietic stem cell volume and recipient's leukocyte count at reinfusion with prognosis of disease in allo-hematopoietic stem cell transplantation[J ] . J Exp Hematol, 2013, 21(6): 1530-1534. DOI: 10.7534/j.issn.1009-2137.2013.06.031.

蔡雪娇孙岚谢作听 ABO血型不合对清髓异基因造血干细胞移植造血重建的影响中华移植杂志:电子版 2012 6 4 250 253 10.3877/cma.j.issn.1647-3903.2012.04.004 蔡雪娇, 孙岚, 谢作听, 等. ABO血型不合对清髓异基因造血干细胞移植造血重建的影响[J].中华移植杂志:电子版, 2012, 6(4): 250-253. DOI: 10.3877/cma.j.issn.1647-3903.2012.04.004.

CAI X J SUN L XIE Z T Effect of ABO-incompatible myeloablative allogeneic hematopoietic stem cell transplantation on hematopoietic engraftment Chin J Transplant (Electronic Edition) 2012 6 4 250 253 10.3877/cma.j.issn.1647-3903.2012.04.004 CAI X J, SUN L, XIE Z T, et al . Effect of ABO-incompatible myeloablative allogeneic hematopoietic stem cell transplantation on hematopoietic engraftment[J ] . Chin J Transplant (Electronic Edition), 2012, 6(4): 250-253. DOI : 10.3877/cma.j.issn.1647-3903.2012.04.004.

宋国梁潘彬齐昆明 HSCT联合不同剂量内皮祖细胞输注对小鼠造血重建的影响中华器官移植杂志 2011 32 11 688 692 10.3760/cma.j.issn.0254-1785.2011.11.012 宋国梁, 潘彬, 齐昆明, 等. HSCT联合不同剂量内皮祖细胞输注对小鼠造血重建的影响[J].中华器官移植杂志, 2011, 32(11): 688-692. DOI: 10.3760/cma.j.issn.0254-1785.2011.11.012.

SONG G L PAN B QI K M Effects of endothelial progenitor cell combined with allogeneic bone marrow transplantation on hematopoietic reconstitution in mice Chin J Organ Transplant 2011 32 11 688 692 10.3760/cma.j.issn.0254-1785.2011.11.012 SONG G L, PAN B, QI K M, et al . Effects of endothelial progenitor cell combined with allogeneic bone marrow transplantation on hematopoietic reconstitution in mice[J ] . Chin J Organ Transplant, 2011, 32(11): 688-692. DOI: 10.3760/cma.j.issn.0254-1785.2011.11.012.

杨贞吴德沛徐杨造血干细胞移植前营养状态与造血重建的关系中华血液学杂志 2012 33 6 496 498 10.3760/cma.j.issn.0253-2727.2012.06.019 杨贞, 吴德沛, 徐杨, 等.造血干细胞移植前营养状态与造血重建的关系[J].中华血液学杂志, 2012, 33(6):496-498. DOI: 10.3760/cma.j.issn.0253-2727.2012.06.019.

YANG Z WU D P XU Y Relationship between nutritional status and hematopoietic reconstitution before transplantation of hematopoietic stem cells Chin J Hematol 2012 33 6 496 498 10.3760/cma.j.issn.0253-2727.2012.06.019 YANG Z, WU D P, XU Y, et al . Relationship between nutritional status and hematopoietic reconstitution before transplantation of hematopoietic stem cells[J ] . Chin J Hematol, 2012, 33(6): 496-498. DOI: 10.3760/cma.j.issn. 0253-2727.2012.06.019.

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