Analgesic effect of different doses of nalbuphine combined with fentanyl by patient-controlled intravenous analgesia for patients after laparoscopic myomectomy

Ya YAN; Cai HE; Heng DAI; Mi LUO; Youchang LI

doi:10.16016/j.1000-5404.201803043

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Analgesic effect of different doses of nalbuphine combined with fentanyl by patient-controlled intravenous analgesia for patients after laparoscopic myomectomy

更新时间：2026-01-09

- Analgesic effect of different doses of nalbuphine combined with fentanyl by patient-controlled intravenous analgesia for patients after laparoscopic myomectomy
- Journal of Third Military Medical University Vol. 40, Issue 17, Pages: 1595-1598(2018)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the Guiding Project of Science and Technology Commission of Yuzhong District, Chongqing(20170156)
- DOI：10.16016/j.1000-5404.201803043
  CLC：
- Received：06 March 2018，
  
  Published：15 September 2018
- 稿件说明：
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Ya YAN, Cai HE, Heng DAI, et al. Analgesic effect of different doses of nalbuphine combined with fentanyl by patient-controlled intravenous analgesia for patients after laparoscopic myomectomy[J]. Journal of Third Military Medical University, 2018, 40(17): 1595-1598.
DOI：

Ya YAN, Cai HE, Heng DAI, et al. Analgesic effect of different doses of nalbuphine combined with fentanyl by patient-controlled intravenous analgesia for patients after laparoscopic myomectomy[J]. Journal of Third Military Medical University, 2018, 40(17): 1595-1598. DOI： 10.16016/j.1000-5404.201803043.

摘要

Abstract

Objective

To investigate the analgesic effect and optimum dose of nalbuphine combined with fentanyl prepared for patient-controlled intravenous analgesia (PCIA) after laparoscopic myomectomy.

Methods

One hundred and sixty patients who had arranged PCIA after laparoscopic myomectomy in our hospital between July and December 2017 were randomly divided into 4 groups (

=40): 40 mg nalbuphine group (N1)

60 mg nalbuphine group (N2)

80 mg nalbuphine group (N3) and 1 000 mg tramadol group (Q). The analgesic agents were respectively diluted with 0.2 mg fentanyl

8 mg ondansetron and 10 mg dexamethasone together to 100 mL with normal saline for PCIA in each group. Ramsay sedation score

visual analog scale (VAS) score at 6

24 and 48 h after surgery

ratio of those needing rescue analgesia

and adverse events were observed.

Results

The VAS scores at different time points and the ratio of those needing rescue analgesia were significantly higher in the group N1 than the other 3 groups (

0.05)

but there was no significant difference among th

e 3 groups (

0.05). The N3 group had the highest Ramsay sedation score and increased incidence of somnolence (

0.05)

and the Q group had higher incidences of nausea and vomiting after operation (

0.05).

Conclusion

Nalbuphine of 60 mg combined with 0.2 mg fentanyl exerts satisfactory analgesic effect and has less adverse events for PCIA after laparoscopic myomectomy.

关键词

Keywords

references

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