Intraoperative <italic style="font-style: italic">in situ</italic> recognition of brain glioma in mice based on terahertz spectroscopy

Tunan CHEN; Jiang LI; Yuye WANG; Ning MU; Kang MA; Hengli ZHAO; Xuegang LI; Long WANG; Pan WANG; Liguo ZHU; Nan WU; Degang XU; Hua FENG; Fei LI

doi:10.16016/j.1000-5404.201802067

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Intraoperative in situ recognition of brain glioma in mice based on terahertz spectroscopy

更新时间：2026-01-09

- Intraoperative in situ recognition of brain glioma in mice based on terahertz spectroscopy
- Journal of Third Military Medical University Vol. 40, Issue 16, Pages: 1444-1449(2018)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the National Basic Research Program of China(2015CB755400);the Support Program of "the Twelfth Five-Year Plan" of Science and Technology(2015BAI01B01);the Joint Incubation project of Southwest Hospital(SWH2016LHJC-01)
- DOI：10.16016/j.1000-5404.201802067
  CLC：
- Received：08 February 2018，
  
  Published：30 August 2018
- 稿件说明：
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Tunan CHEN, Jiang LI, Yuye WANG, et al. Intraoperative in situ recognition of brain glioma in mice based on terahertz spectroscopy[J]. Journal of Third Military Medical University, 2018, 40(16): 1444-1449.
DOI：

Tunan CHEN, Jiang LI, Yuye WANG, et al. Intraoperative in situ recognition of brain glioma in mice based on terahertz spectroscopy[J]. Journal of Third Military Medical University, 2018, 40(16): 1444-1449. DOI： 10.16016/j.1000-5404.201802067.

摘要

Abstract

Objective

To explore the technical feasibility of intraoperative positioning and qualitative diagnosis of brain gliomas using terahertz spectroscopy.

Method

At an air humidity of 10%

a reflective full-fiber terahertz time-domain spectrum system was used to obtain terahertz time-domain pulse signals of mouse brain

gliomas and normal brain tissues on the surface of the cerebral hemisphere.The spectral parameters of the gliomas and normal brain tissues were extracted and analyzed for their differences for

in situ

recognition of the tumors.

Results

Normal mouse brain tissues and brain gliomas showed significantly different refractivity within the range of 0.4 to 0.6 THz and significantly different absorption coefficients within the range of 0.4 to 0.9 THz.The tumor and normal brain tissues could be effectively recognized and positioned based on the differences of the parameters of terahertz spectroscopy.

Conclusion

Our preliminary findings verify the possibility of using terahertz spectroscopy for intraoperative

in situ

recognition of gliomas to provide assistance in precision tumor resection.

关键词

Keywords

references

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Related Institution

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⁰

Intraoperative in situ recognition of brain glioma in mice based on terahertz spectroscopy

DOI：10.16016/j.1000-5404.201802067

摘要

Abstract

关键词

Keywords

references