Construction of three-dimensional models of cardiac fibrous skeleton and valves and application of the 3D printed models

Xiaoqin ZHANG; Ying LI; Liwen TAN; Shaoxiang ZHANG

doi:10.16016/j.1000-5404.201801132

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Construction of three-dimensional models of cardiac fibrous skeleton and valves and application of the 3D printed models

Basic Medicine | 更新时间：2026-01-09

- Construction of three-dimensional models of cardiac fibrous skeleton and valves and application of the 3D printed models
- Journal of Third Military Medical University Vol. 40, Issue 14, Pages: 1251-1257(2018)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)生物医学工程与影像医学系，数字医学研究所
- 作者简介：
- 基金信息：
  
  Supported by the Major Program of National Natural Science Foundation of China (61190122), the Special Project for Social Livelihood Science and Technology Innovation of Chongqing (CSTC2015shmszx120002, cstc2017shms-zdyfX0015)
- DOI：10.16016/j.1000-5404.201801132
  CLC： R319;R322.11
- Received：16 January 2018，
  
  Revised：2018-03-26，
  
  Published：30 July 2018
- 稿件说明：
移动端阅览
Xiaoqin ZHANG, Ying LI, Liwen TAN, et al. Construction of three-dimensional models of cardiac fibrous skeleton and valves and application of the 3D printed models[J]. Journal of Third Military Medical University, 2018, 40(14): 1251-1257.
DOI：

Xiaoqin ZHANG, Ying LI, Liwen TAN, et al. Construction of three-dimensional models of cardiac fibrous skeleton and valves and application of the 3D printed models[J]. Journal of Third Military Medical University, 2018, 40(14): 1251-1257. DOI： 10.16016/j.1000-5404.201801132.

摘要

目的

探讨利用中国可视化人体(Chinese visible human

CVH)数据集建立3D打印心脏纤维骨架及瓣膜(cardiac fibrous skeleton and valves

CFSV)模型的效果及应用价值。

方法

先将CVH数据集第5例(CVH5)高分辨率断层图像导入Amira软件

对CFSV结构进行分割并重建其三维模型

经平滑、简化后进行3D打印

然后对3D打印模型进行打磨、着色等后处理

最后对其进行测量和分析。

结果

成功完成CFSV三维模型的构建和3D打印。对比数字化三维模型和3D打印实体模型的直径测量数据(mm):在短轴上

三尖瓣环(tricuspid valve ring

TVR)(26.56

26.48)

二尖瓣环(mitral valve ring

MVR)(27.67

26.08);在长轴上

TVR (42.64

41.02)

MVR (37.93

38.74);两种模型测量值的差异δ为(0.62±1.19) mm。肺动脉瓣的面积和周长均比主动脉瓣略大

TVR的周长和面积比MVR大

TVR和MVR所在平面的角度相差约20.4°。

结论

利用CVH数据集建立3D打印CFSV模型

可完整展现人体心脏纤维骨架原位解剖空间

在复杂、不规则形态的测量上更具优势。

Abstract

Objective

To construct a three-dimensional (3D) model of cardiac fibrous skeleton and valves (CFSV) using the Chinese Visible Human (CVH) dataset and explore the utility of the 3D printed model in clinical practice and in medical anatomy teaching.

Methods

The CVH5 high-resolution tomographic images were imported into Amira software for segmentation and reconstruction of the CFSV. The reconstructed 3D model was smoothed and simplified

and was then imported into the 3D printer for printing. Anatomical measurements were conducted following post-processing of the 3D printed model by polishing and coloring.

Results

The 3D model of CFSV was successfully reconstructed and printed. Anatomical measurements using the digital 3D model and the 3D printed model showed that the minor axis of the tricuspid valve ring (TVR) was 26.56 mm

26.48 mm

and that of the mitral valve ring (MVR) was 27.67 mm

26.08 mm; the long axis of the TVR was 42.64 mm

41.02 mm and that of the MVR was 37.93 mm

mm 38.74 mm. The mean difference between the measurements on the 2 models was 0.62±1.19 mm. The measured area and the circumference of the pulmonary valve were slightly larger than those of the aortic valve. The perimeter and area of the TVR were larger than the MVR

and the angle between the planes of the TVR and the MVR was about 20.40.

Conclusion

The 3D printed model of the CFSV well displays the anatomical structures

with the advantages in measurement of complex and irregular structures

关键词

Keywords

references

王媛, 王墨扬, 任心爽, 等. 3D打印技术在心脏瓣膜病领域的应用进展[J].中华心血管病杂志, 2017, 45(2): 167-169.

WANG Y, WANG M Y, REN X S, et al. The application of 3D printing in the field of heart valvular disease[J]. Chin J Cardiol, 2017, 45(2): 167-169.

MURARU D, VERONESI F, MADDALOZZO A, et al. 3D printing of normal and pathologic tricuspid valves from transthoracic 3D echocardiography data sets[J]. Eur Heart J Cardiovasc Imaging, 2017, 18(7): 802-808.

MAHMOOD F, OWAIS K, TAYLOR C, et al. Three-dimensional printing of mitral valve using echocardiographic data[J]. JACC Cardiovasc Imaging, 2015, 8(2): 227-229. DOI: 10.1016/j.jcmg.2014.06.020.

LITTLE S H, VUKICEVIC M, AVENATTI E, et al. 3D Printed Modeling for Patient-Specific Mitral Valve Intervention: Repair With a Clip and a Plug[J]. JACC Cardiovasc Interv, 2016, 9(9): 973-975. DOI: 10.1016/j.jcin.2016.02.027.

GALLO M, D'ONOFRIO A, TARANTINI G, et al. 3D-printing model for complex aortic transcatheter valve treatment[J]. Int J Cardiol, 2016, 210: 139-140. DOI: 10.1016/j.ijcard.2016.02.109.

肖嵛, 谭立文, 向明滟, 等.基于数字化人体的高精度器官模型3D打印初探[J].第三军医大学学报, 2015, 37(21): 2147-2150.

XIAO Y, TAN L W, XIANG M Y, et al. Application of 3D printing techniques in human organ models from Chinese Visible Human[J]. J Third Mil Med Univ, 2015, 37(21): 2147-2150. DOI:10.16016/j.1000-5404.201503141.

李颖. 心脏可视化研究及其在量化分析中的应用[D]. 重庆: 第三军医大学, 2016. [http://cdmd.cnki.com.cn/Article/CDMD-90031-1017035241.htm .

LI Y. Visualization study of the heart and its application in quantitative analysis[D]. Chongqing: Third Military Medical University, 2016.

GORDIC S, NGUYEN-KIM T D, MANKA R, et al. Sizing the mitral annulus in healthy subjects and patients with mitral regurgitation: 2D versus 3D measurements from cardiac CT[J]. Int J Cardiovasc Imaging, 2014, 30(2): 389-398. DOI: 10.1007/s10554-013-0341-4.

MIHAILA S, MURARU D, PIASENTINI E, et al. Quantitative analysis of mitral annular geometry and function in healthy volunteers using transthoracic three-dimensional echocardiography[J]. J Am Soc Echocardiogr, 2014, 27(8): 846-857. DOI: 10.1016/j.echo.2014.04.017.

MAFFESSANTI F, GRIPARI P, PONTONE G, et al. Three-dimensional dynamic assessment of tricuspid and mitral annuli using cardiovascular magnetic resonance[J]. Eur Heart J Cardiovasc Imaging, 2013, 14(10): 986-995. DOI: 10.1093/ehjci/jet004.

MIGLIORANZA M H, MIHAILA S, MURARU D, et al. Dynamic changes in tricuspid annular diameter measurement in relation to the echocardiographic view and timing during the cardiac cycle[J]. J Am Soc Echocardiogr, 2015, 28(2): 226-235. DOI: 10.1016/j.echo.2014.09.017.

OWAIS K, TAYLORC E, JIANGL, et al. Tricuspid annulus: a three-dimensional deconstruction and reconstruction[J]. Ann Thorac Surg, 2014, 98(5): 1536-1542. DOI: 10.1016/j.athoracsur.2014.07.005.

VERONESI F, ADDETIAK, LAMBERTIC, et al. 3D evaluation of tricuspid annulus morphology in patients with pulmonary hypertension[C]//Computing in Cardiology Conference. IEEE, 2013: 241-244.

MISFELD M, SIEVERSH H. Heart valve macro- and microstructure[J]. Philos Trans R Soc Lond B Biol Sci, 2007, 362(1484): 1421-1436.

RIPLEY B, KELILT, CHEEZUMM K, et al. 3D printing based on cardiac CT assists anatomic visualization prior to transcatheter aortic valve replacement[J]. J Cardiovasc Comput Tomogr, 2016, 10(1): 28-36. DOI: 10.1016/j.jcct.2015.12.004.

VUKICEVIC M, PUPERID S, JANE GRANDE-ALLENK, et al. 3D printed modeling of the mitral valve for catheter-based structural interventions[J]. Ann Biomed Eng, 2017, 45(2): 508-519. DOI: 10. 1007/s10439-016-1676-5.

YANG D H, KIMD H, HANDSCHUMACHERM D, et al. In vivo assessment of aortic root geometry in normal controls using 3D analysis of computed tomography[J]. Eur Heart J Cardiovasc Imaging, 2017, 18(7):780-786. DOI: 10.1093/ehjci/jew146.

郝凤阳, 苏健, 孙璐, 等.人工心脏瓣膜的发展[J].医疗装备, 2017, 30(13): 186-190.

HAO F Y, SU J, SUN L, et al. Development of artificial heart valve[J]. Med Equipment, 2017, 30(13): 186-190.

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