Relationship of total bile acid level and timing of termination with perinatal outcomes in intrahepatic cholestasis of pregnancy

Fenglian XIAO; Yingru ZHENG

doi:10.16016/j.1000-5404.201801128

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Relationship of total bile acid level and timing of termination with perinatal outcomes in intrahepatic cholestasis of pregnancy

更新时间：2026-01-09

- Relationship of total bile acid level and timing of termination with perinatal outcomes in intrahepatic cholestasis of pregnancy
- Journal of Third Military Medical University Vol. 40, Issue 11, Pages: 1028-1032(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201801128
  CLC：
- Received：15 January 2018，
  
  Published：15 June 2018
- 稿件说明：
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Fenglian XIAO, Yingru ZHENG. Relationship of total bile acid level and timing of termination with perinatal outcomes in intrahepatic cholestasis of pregnancy[J]. Journal of Third Military Medical University, 2018, 40(11): 1028-1032.
DOI：

Fenglian XIAO, Yingru ZHENG. Relationship of total bile acid level and timing of termination with perinatal outcomes in intrahepatic cholestasis of pregnancy[J]. Journal of Third Military Medical University, 2018, 40(11): 1028-1032. DOI： 10.16016/j.1000-5404.201801128.

摘要

Abstract

Objective

To determine the association of the perinatal outcomes with the level of total bile acid (TBA) and timing of termination in intrahepatic cholestasis of pregnancy (ICP).

Methods

A retrospective study was conducted among 198 women suffering from ICP treated in our hospital from March 2013 to June 2017. According to the level of TBA

the women were divided into 3 groups

that is

10~39.99 μmol/L (group Ⅰ)

40~99.99 μmol/L (group Ⅱ) and ≥100 μmol/L (group Ⅲ). On the basis of termination

the cases were also divided into 3 groups

36 weeks gestation (group A)

36~36

weeks (group B)

and ≥37 weeks gestation (group C). The adverse perinatal outcomes of low birth weight

meconium-stained amniotic fluid (MSAF)

neonatal intensive care unit (NICU) admission

neonatal myocardial damage

pneumonia

hyperbilirubinemia

neonatal respiratory distress syndrome (NRDS) of perinatal infant were analyzed.

Results

The incidence of adverse perinatal outcomes in group ⅠA was significantly higher than those of groups ⅠB and ⅠC (

0.05). The incidence of low birth weight in group ⅠB was significantly higher than that in group ⅠC (

0.05). The incidence of NICU admission in group ⅠB was lower than that in group ⅠC

but without statistical difference (

0.05). The incidence of adverse perinatal outcomes in group ⅡA was notably higher than those in groups ⅡB and ⅡC (

0.05). The incidences of low birth weight and recent complications in group ⅡB were higher than those in group ⅡC

but there was no significant difference (

0.05). No newborns in groups ⅡB andⅡC entered in the NICU. The gestational age o

f onset in group Ⅲ was shorter than 34 weeks

and the incidence of adverse outcomes in the perinatal infants was higher when the gestational age was shorter than 36 weeks.

Conclusion

When serum TBA ranged from 10 to 40 μmol/L

termination of 37 weeks gestation is recommended to decrease the adverse perinatal outcomes of ICP

and when the range was 40~100 μmol/L

36 weeks gestation of termination is a strategy. While

for the women with TBA ≥100 μmol/L

termination should depend on maturation of the fetus.

关键词

Keywords

references

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