Evaluation of macular changes in early-stage familial exudative vitreoretinopathy: a cross-sectional, case-control study

Meijun PU; Ziyang LI; Xiaoyong HUANG

doi:10.16016/j.1000-5404.201801099

您当前的位置：

首页 >

文章列表页 >

Evaluation of macular changes in early-stage familial exudative vitreoretinopathy: a cross-sectional, case-control study

Clinical Medicine | 更新时间：2026-01-09

- Evaluation of macular changes in early-stage familial exudative vitreoretinopathy: a cross-sectional, case-control study
- Journal of Third Military Medical University Vol. 40, Issue 10, Pages: 923-927(2018)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院眼科
- 作者简介：
- 基金信息：
  
  the General Pragram of National Natural Science Foundation of China(31071202);the Project of Clinical Innovation of Army Medical University(SWH2014LC12);the Clinical New Fechnology Plan of Military Medicine and War Trauma Rescue of Southwest Hospital(SWH2016YSCXYB-09)
- DOI：10.16016/j.1000-5404.201801099
  CLC： R195.4;R774.1;R774.5
- Received：11 January 2018，
  
  Revised：2018-03-06，
  
  Published：30 May 2018
- 稿件说明：
移动端阅览
Meijun PU, Ziyang LI, Xiaoyong HUANG. Evaluation of macular changes in early-stage familial exudative vitreoretinopathy: a cross-sectional, case-control study[J]. Journal of Third Military Medical University, 2018, 40(10): 923-927.
DOI：

Meijun PU, Ziyang LI, Xiaoyong HUANG. Evaluation of macular changes in early-stage familial exudative vitreoretinopathy: a cross-sectional, case-control study[J]. Journal of Third Military Medical University, 2018, 40(10): 923-927. DOI： 10.16016/j.1000-5404.201801099.

摘要

目的

观察早期家族性渗出性玻璃体视网膜病变(familial exudative vitreoretinopathy

FEVR)患者的黄斑特征，并探讨其有无先天性黄斑发育异常。

方法

采用横断面研究，共纳入2014年9月至2017年10月在陆军军医大学第一附属医院就诊的FEVR患者31例37眼，对照组30例30眼。应用SD-OCT获取黄斑部图像，测量最佳矫正视力及黄斑中心凹厚度，采用SPSS23.0统计软件作数据分析。

结果

早期FEVR患者黄斑中心凹厚度与对照组相比，差异无统计学意义。早期FEVR患者黄斑结构异常有11眼(29.7%)，均为继发性黄斑结构异常，其中椭圆体带连续性中断较为常见，黄斑结构正常26眼(70.3%)，黄斑结构异常组视力低于黄斑结构正常组，差异有统计学意义(

=0.001)，黄斑结构正常组视力与对照组相比，差异无统计学意义。

结论

FEVR患者无先天性黄斑发育异常，多数患者黄斑结构正常，一旦发生继发性黄斑结构异常，可显著影响视力。OCT是监测FEVR病变进展的重要手段。

Abstract

Objective

To observe the macular changes and investigate the presence of congenital macular dysplasia in patients with familial exudative vitreoretinopathy (FEVR).

Methods

This cross-sectional

case-control study was conducted among 31 patients with early-stage FEVR (37 eyes) treated in the First Affiliated Hospital of the Army Medical University between September

2014 to October

2017

with 30 healthy subjects (30 eyes) as the control group. All the subjects underwent examinations of the best corrected visual acuity (BCVA)

spectral-domain optical coherencetomography (SD-OCT) and fluorescence fundus angiography (FFA).

Results

No significant difference was found in the central foveal thickness between FEVR group and control group. In FEVR group

11 eyes (29.7%) in 8 cases showed macular abnormalities

which were all secondary abnormalities featuring a disruption of the ellipsoid zone as the most common finding on SD-OCT; 26 eyes (70.3%) in 25 cases had normal macula. The eyes with macular abnormalities had a significantly lower BCVA than those with normal macular findings (

=0.001). No significant difference was found in the B

CVA between the eyes in normal macular group and control group.

Conclusion

Patients with FEVR do not have congenital developmental abnormalities in the macula

and most of the patients with early-stage FEVR have normal macula. However

secondary macular abnormalities can lead to severe visual impairment

and OCT can serve as an important means to monitor the progression of FEVR.

关键词

Keywords

references

CRISWICK V G, SCHEPENS C L. Familial exudative vitreoretinopathy[J]. Am J Ophthalmol, 1969, 68(4): 578-594.

PENDERGAST S D, TRESE M T. Familial exudative vitreoretinopathy. Results of surgical management[J]. Ophthalmology, 1998, 105(6): 1015-1023. DOI: 10.1016/S0161-6420(98)96002-X.

MIYAKUBO H, HASHIMOTO K, MIYAKUBO S. Retinal vascular pattern in familial exudative vitreoretinopathy[J]. Ophthalmology, 1984, 91(12): 1524-1530.

CHEN S N, HUANG J F, LIN C J. Clinical characteristics and surgical management of familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment[J]. Retina, 2012, 32(2): 220-225.DOI:10.1097/IAE.0b013e31821c3ec5.

YUAN M, YANG Y, YAN H, et al .Increased posterior retinal vessels in mild asymptomatic familial exudative vitreoretinapathy eyes[J ] .Retina, 2016, 36(6): 1209-1215.DOI: 10.1097/IAE.0000000000000830.

YONEKAWA Y, THOMAS B J, DRENSER K A, et al .Familial exudative vitreoretinopathy: spectral-domain optical coherence tomography ofthevitreoretinal interface, retina, and choroid[J ] .Ophthalmology, 2015, 122(11): 2270-2277. DOI: 10.1016/j.ophtha.2015.07.024.

WELEBER R G, PENNESI M E, WILSON D J, et al . Results at 2 years after gene therapy for RPE65-deficient leber congenital amaurosis and severe early-childhood-onset retinal dystrophy[J ] . Ophthalmology, 2016, 123(7): 1606-1620. DOI: 10.1016/j.ophtha.2016.03.003.

CHACON-CAMACHOÓF, ZENTENO J C.Gene therapy for vision restorationin patients with Leber congenital amaurosis (LCA) due to RPE65 gene mutations: beginning the phase Ⅳ trial[J]. Gac Med Mex, 2017, 153(2): 276-278.

BAINBRIDGE J W, MEHAT M S, SUNDARAM V, et al . Long-term effect of gene therapy on Leber's congenital amaurosis[J ] . N Engl J Med, 2015, 372(20): 1887-1897. DOI: 10.1056/NEJMoa1414221.

TERAUCHI G, SHINODA K, MATSUMOTO C S, et al . Recovery of photoreceptor inner and outer segment layer thickness after reattachment of rhegmatogenous retinal detachment[J ] . Br J Ophthalmol, 2015, 99(10): 1323-1327. DO I: 10.1136/bjophthalmol-2014-306252.

GROSSNIKLAUS H E, GREEN W R. Pathologic findings in pathologic myopia[J]. Retina, 1992, 12(2): 127-133.

SPAIDE R F, KLANCNIK J M JR, COONEY M J.Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography[J]. JAMA Ophthalmol, 2015, 133(1): 45-50. DOI: 10.1001/jamaophthalmol.2014.3616.

SOARES M, NEVES C, MARQUES I P, et al . Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography[J ] . Br J Ophthalmol, 2017, 101(1): 62-68. DOI: 10.1136/bjophthalmol-2016-309424.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰