Correlation of plasma heme oxygenase-1 and matrix metalloproteinase-9 with coronary artery disease

Jingjing LIU; Lisheng JING; Jun WANG

doi:10.16016/j.1000-5404.201712054

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Correlation of plasma heme oxygenase-1 and matrix metalloproteinase-9 with coronary artery disease

Clinical Medicine | 更新时间：2026-01-09

- Correlation of plasma heme oxygenase-1 and matrix metalloproteinase-9 with coronary artery disease
- Journal of Third Military Medical University Vol. 40, Issue 13, Pages: 1247-1250(2018)
- 作者机构：
  
  102300 北京，北京市门头沟区医院心内科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201712054
  CLC： R345;R446.112;R541.4
- Received：01 December 2017，
  
  Revised：2018-01-05，
  
  Published：15 July 2018
- 稿件说明：
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Jingjing LIU, Lisheng JING, Jun WANG. Correlation of plasma heme oxygenase-1 and matrix metalloproteinase-9 with coronary artery disease[J]. Journal of Third Military Medical University, 2018, 40(13): 1247-1250.
DOI：

Jingjing LIU, Lisheng JING, Jun WANG. Correlation of plasma heme oxygenase-1 and matrix metalloproteinase-9 with coronary artery disease[J]. Journal of Third Military Medical University, 2018, 40(13): 1247-1250. DOI： 10.16016/j.1000-5404.201712054.

摘要

目的

探讨血浆血红素加氧酶1(heme oxygenase-1 HO-1)和血浆基质金属蛋白酶9(matrix metalloproteinase-9，MMP-9)与冠心病的相关性。

方法

选择2011年3月至2014年12月在北京市门头沟区医院心内科疑似冠心病的住院患者292例，其中男性167例，女性125例；年龄34~90(64±12)岁。根据冠脉造影(coronary angiography，CAG)结果分为对照组(143例)和冠心病组(149例)，冠心病组根据病变支数又分为单支病变(38例)、双支病变(46例)、多支病变(65例)，测量患者HO-1及MMP-9水平，计算冠心病组Gensini积分；同时收集病史、尿酸、血脂、高敏C反应蛋白、糖化血红蛋白等指标，评价HO-1、MMP-9与冠心病的相关性。

结果

① 冠心病组MMP-9及Gensini积分明显高于对照组(

＜0.05)，HO-1水平明显低于对照组(

＜0.05)；②MMP-9及Gensini积分随着病变血管数增加而升高(

＜0.05)，HO-Ⅰ水平则降低(

＜0.05)；③HO-1与Gensini积分呈负相关(

=-0.952，

＜0.01)，MMP-9与Gensini积分呈正相关(

=0.881，

＜0.01)，HO-1与MMP-9呈负相关(

=-0.818，

＜0.01)。

结论

血浆中HO-1和MMP-9水平与冠心病有关。

Abstract

Objective

To investigate the correlation of heme oxygenase-1 (HO-1) and matrix metalloproteinase-9 (MMP-9) with coronary artery disease (CAD).

Methods

A prospective cohort study was carried out on 292 inpatients (167 males and 125 females

at a mean age of 64±12 years

ranging from 34 to 90 years) with suspected CAD admitted in our department during March 2011 and December 2014. According to the results of coronary angiography (CAG)

the patients were divided into control group (

=143) and CAD group (

=149). According to the number of vessels involved

the patients of CAD group was further divided into one-vessel subgroup (

=38)

two-vessel subgroup (

=46)

and multi-vessel subgroup (

=65). The plasma levels of HO-1 and MMP-9 were measured in all the patients

their medical history was colle

cted

and the results of uric acid

blood lipids

high sensitivity C-reactive protein (Hs-CRP)

glycosylated hemoglobin were recorded. Gensini's score was calculated in the CAD group. The correlations of HO-1 and MMP-9 with CAD were analyzed.

Results

① The MPV level and Gensini's score in the CAD group were obviously higher than those in the control group (

0.05)

while the level of HO-1 was significantly lower (

0.05). ② With more vessels involved

the MMP-9 level and Gensini's score were significantly increased (

0.05)

while the HO-1 level was notably decreased (

0.05). ③ The level of HO-1 was negatively correlated with Gensini's score (

=-0.952

0.01)

while that of MMP-9 was positively (

=0.881

0.01). Furthermore

the levels of the 2 indicators were negatively correlated (

=－0.818

0.01).

Conclusion

Plasma HO-1 and MMP-9 levels are associated with CAD.

关键词

Keywords

references

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