Factors affecting the quality of life in patients during treatment for wet age-related macular degeneration: a longitudinal cohort study

Wei BIAN; Junli WAN; Mingqiong TAN; Jun SU; Yang LIU; Shiying LI

doi:10.16016/j.1000-5404.201711187

您当前的位置：

首页 >

文章列表页 >

Factors affecting the quality of life in patients during treatment for wet age-related macular degeneration: a longitudinal cohort study

更新时间：2026-03-02

- Factors affecting the quality of life in patients during treatment for wet age-related macular degeneration: a longitudinal cohort study
- Journal of Third Military Medical University Vol. 40, Issue 4, Pages: 356-361(2018)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院眼科Department of Ophthalmology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China
- 作者简介：
- 基金信息：
  
  the Youth Innovation Project of Southwest Hospital of Third Military Medical University(SWH2015QN04)
- DOI：10.16016/j.1000-5404.201711187
  CLC： R195.4; R492; R744.5
- Received：21 November 2017，
  
  Published：28 February 2018
- 稿件说明：
移动端阅览
Wei BIAN, Junli WAN, Mingqiong TAN, et al. Factors affecting the quality of life in patients during treatment for wet age-related macular degeneration: a longitudinal cohort study[J]. Journal of Third Military Medical University, 2018, 40(4): 356-361.
DOI：

Wei BIAN, Junli WAN, Mingqiong TAN, et al. Factors affecting the quality of life in patients during treatment for wet age-related macular degeneration: a longitudinal cohort study[J]. Journal of Third Military Medical University, 2018, 40(4): 356-361. DOI： 10.16016/j.1000-5404.201711187.

摘要

目的

采用前瞻性的纵向研究设计，探讨人口学和专科资料以及社会心理因素对老年黄斑变性(age-related macular degeneration，AMD)患者不同治疗期生存质量的影响。

方法

采用方便抽样法选取2016年1月至2017年9月就诊于我院门诊的137例AMD患者作为研究对象，分别在治疗后1、3、6个月3个时间点，采用问卷调查对其生存质量及影响因素进行测评。

结果

治疗后3个月的生存质量最差，为(54.25±13.37)分，治疗后1个月生存质量最好，为(62.10±15.86)分，且3个不同治疗期的生存质量差异有统计学意义(

=11.518，

=0.000)。对生存质量影响因素的多元逐步回归分析显示：治疗手段(

0.01)、文化程度(

0.01)、婚姻状况(

0.01)、焦虑(

0.01)、抑郁(

0.05)、自我效能(

0.01)、社会支持(

0.05)和积极应对(

0.01)是AMD患者生存质量的主要影响因素。

结论

AMD患者治疗后6个月中的不同阶段其生存质量及影响因素是动态变化的，为护理人员精准制订多阶段、有针对性的干预措施提供了理论依据。

Abstract

Objective

To survey the quality of life and the factors affecting the quality of life of patients with age-related macular degeneration (AMD) in different phases of treatment.

Methods

The convenience sampling was used for selecting 137 patients with AMD admitted in our department between January

2016 and September

2017. Follow-up survey for quality of life of the patients was conducted at 1

3 and 6 months during the treatment.

Results

The mean score for quality of life was the lowest at 3 months (54.25±13.37)

and was the highest at 1 month during the treatment (62.10±15.86). Multivariate regression analysis identifie

d the type of disease (

0.01)

education level (

0.01)

marital status (

0.01)

anxiety (

0.01)

depression (

0.05)

self-efficacy (

0.01)

social support (

0.05) and positive coping style (

0.01) as the factors that significantly affected the quality of life in the patients during treatment.

Conclusion

The factors affecting the quality of life of patients with ADM change with time during the treatment

and multi-staged

targeted interventions of these factors

preferentially within the initial 6 months during treatment

can improve the quality of life among the patients.

关键词

Keywords

references

WONG W L, SU X, LI X, et al . Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis[J ] . Lancet Glob Health, 2014, 2(2): e106-e116. DOI: 10.1016/S2214-109X(13)70145-1.

KARAMPELAS M, PEFKIANAKI M, REES A, et al . Missed hospital appointments of patients receiving ranibizumab therapy for neovascular Age-Related Macular Degeneration[J ] . Ophthalmol Therap, 2015, 4(1): 43-49. DOI: 10.1007/s40123-015-0031-5.

YUZAWA M, FUJITA K, TANAKA E, et al . Assessing quality of life in the treatment of patients with age-related macular degeneration: clinical research findings and recommendations for clinical practice[J ] . Clin Ophthalmol, 2013, 7: 1325-1332. DOI: 10.2147/OPTH.S45248.

TAYLOR D J, HOBBY A E, BINNS A M, et al . How does age-related macular degeneration affect real-world visual ability and quality of life? A systematic review[J ] . BMJ Open, 2016, 6(12): e011504. DOI: 10.1136/bmjopen-2016-011504.

FENWICK E K, CHEUNG G C M, TI GAN A, et al . Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration[J ] . Br J Ophthalmol, 2017. [Epub ahead of print ] . DOI: 10.1136/bjophthalmol-2017-310532.

卞薇, 万君丽, 于文春, 等.湿性老年黄斑变性患者治疗期适应性挑战的现象学研究[J].中国护理管理, 2017, 17(10): 1331-1335.DOI: 10.3969/j.issn.1672-1756.2017.10.009.

BIAN W, WANG J L, YU W C, et al . A qualitative study on the adaptive challenge of patients with age-related macular degeneration during therapy[J ] . Chin Nurs Management, 2017, 17(10): 1331-1335. DOI: 10.3969/j.issn.1672-1756.2017.10.009.

DEEMER A D, MASSOF R W, ROVNER B W, et al . Functional outcomes of the low vision depression prevention trial in age-related macular degeneration[J ] . Invest Ophthalmol Vis Sci, 2017, 58(3): 1514-1520. DOI: 10.1167/iovs.16-20001.

MANGIONE C M, LEE P P, GUTIERREZ P R, et al . Development of the 25-item national eye institute visual function questionnaire[J ] . Arch Ophthalmol, 2001, 119(7): 1050-1058.

汪向东, 王希林, 马弘. 心理卫生评定量表手册[J]. 中国心理卫生杂志, 1999(增): 31-35, 127-131, 194-197, 235-238.

WANG X D, WANG X L, MA H. Manual of mental health assessment scale[J]. Chin J Mental Health, 1999(Suppl): 31-35, 127-131, 194-197, 235-238.

RADLOFF L S. The CES-D Scale: A self-report depression scale for research in the general population[J]. Appl Psychol Meas, 1977, 1(3): 385-401.

解亚宁.简易应对方式量表信度和效度的初步研究[J].中国临床心理学杂志, 1998, 6(2): 114-115.

XIE Y N. A preliminary study of the reliability and validity of a simple coping style scale[J]. Chin J Clin Psychol, 1998, 6(2): 114-115.

王才康, 胡中锋, 刘勇.一般自我效能感量表的信度和效度研究[J].应用心理学, 2001, 7(1): 37-40. DOI: 10.3969/j.issn.1006-6020.2001.01.007.

WANG C K, HU Z F, LIU Y. Evidences for reliability and validity of the chinese version of general self-efficacy scale[J]. Chin J Appl Psychol, 2001, 7(1): 37-40. DOI: 10.3969/j.issn.1006-6020.2001.01.007.

MCCLOUD C, KHADKA J, GILHOTRA J S, et al . Divergence in the lived experience of people with macular degeneration[J ] . Optom Vis Sci, 2014, 91(8): 966-974. DOI: 10.1097/OPX.0000000000000320.

MATAMOROS E, MAUREL F, LÉON N, et al . Quality of life in patients suffering from active exudative age-related macular degeneration: the EQUADE study[J ] . Ophthalmologica, 2015, 234(3): 151-159. DOI: 10.1159/000433448.

RYAN B. Models of low vision care: past, present and future[J]. Clin Exp Optom, 2014, 97(3): 209-213. DOI: 10.1111/cxo.12157.

ŠIAUDVYTYT Ė L, MITKUT Ė D, BALČIŪNIENĖ J. Quality of life in patients with age-related macular degeneration[J]. Medicina (Kaunas), 2012, 48(2): 109-111.

刘晓静, 邹海东, 吴星伟.年龄相关性黄斑变性患者视觉相关生存质量变化及相关因素分析[J].上海交通大学学报(医学版), 2012, 32(2): 197-201. DOI: 10.3969/j.issn.1674-8115.2012.02.016.

LIU X J, ZOU H D, WU X W. Vision-related quality of life and related factors in patients with age-related macular degeneration[J]. J Shanghai Jiaotong Univ(Med Sci), 2012, 32(2): 197-201. DOI: 10.3969/j.issn.1674-8115.2012.02.016.

CHATZIRALLI I, MITROPOULOS P, PARIKAKIS E, et al .Risk Factors for Poor Quality of Life among Patients with Age-Related Macular Degeneration[J ] . Semin Ophthalmol, 2017, 32(6): 772-780. DOI: 10.1080/08820538.2016.1181192.

AUGUSTIN A, SAHEL J A, BANDELLO F, et al . Anxiety and depression prevalencerates in age-related macular degeneration[J ] . Invest Ophthalmol Vis Sci, 2007, 48(4): 1498-1503. DOI: 10.1167/iovs.06-0761.

MUDRAK J, STOCHL J, SLEPICKA P, et al . Physical activity, self-efficacy, and quality of life in older Czech adults[J ] . Eur J Ageing, 2015, 13(1): 5-14. DOI: 10.1007/s10433-015-0352-1.

REES G, KEEFFE J E, HASSELL J, et al . A self-management program for low vision: program overview and pilot evaluation[J ] . Disabil Rehabil, 2010, 32(10): 808-815. DOI: 10.3109/09638280903304193.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

Jia WANG

Jingxuan ZHANG

Yitong XUE

Ke XU

Hong XIAO

Huimin XU

Huizhong WANG

Zhengzhi FENG

Related Institution

Department of Developmental Psychology for Armyman, Faculty of Medical Psychology, Army Medical University (Third Military Medical University)

Graduate School, Army Medical University (Third Military Medical University)

Department of Neurology, First Affiliated Hospital, Army Medical University(Third Military Medical University)

Department of Radiology, First Affiliated Hospital, Army Medical University (Third Military Medical University)

⁰