Effect of staged oral administration of low-concentration polyethylene glycol electrolyte solution for bowel preparation: a randomized controlled trial

Yang ZHANG; Chunhua LI; Yizhuo WANG; Jin YU; Hui LIN; Guoce ZHAO

doi:10.16016/j.1000-5404.201711052

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Effect of staged oral administration of low-concentration polyethylene glycol electrolyte solution for bowel preparation: a randomized controlled trial

更新时间：2026-03-02

- Effect of staged oral administration of low-concentration polyethylene glycol electrolyte solution for bowel preparation: a randomized controlled trial
- Journal of Third Military Medical University Vol. 40, Issue 4, Pages: 345-349(2018)
- 作者机构：
  
  400037 重庆，陆军军医大学(第三军医大学)第二附属医院消化内科Department of Gastroenterology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201711052
  CLC： R322.45;R619;R979.9
- Received：08 November 2017，
  
  Published：28 February 2018
- 稿件说明：
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Yang ZHANG, Chunhua LI, Yizhuo WANG, et al. Effect of staged oral administration of low-concentration polyethylene glycol electrolyte solution for bowel preparation: a randomized controlled trial[J]. Journal of Third Military Medical University, 2018, 40(4): 345-349.
DOI：

Yang ZHANG, Chunhua LI, Yizhuo WANG, et al. Effect of staged oral administration of low-concentration polyethylene glycol electrolyte solution for bowel preparation: a randomized controlled trial[J]. Journal of Third Military Medical University, 2018, 40(4): 345-349. DOI： 10.16016/j.1000-5404.201711052.

摘要

目的

采用随机对照试验评价3 L低浓度分阶段口服复方聚乙二醇电解质溶液(polyethylene glycol electrolyte，PEG)在结肠镜检查前的肠道准备的效果和不良反应。

方法

以2017年2月1日至2017年5月31日在本院消化科拟行结肠镜检查的全部患者300例作为研究对象，采用计算机随机数字表将其分为A组(3 L低浓度分阶段组)和B组(2 L传统浓度组)，结肠镜检查医师和护士盲法采用Boston肠道准备量表(boston bowel preparation scale

BBPS)进行评分和询问记录不良反应发生情况。

结果

两组患者的平均年龄、性别比例、身高、体质量和文化程度等一般特征差异无统计学意义(

0.05)。A组肠道准备有效率(BBPS≥5分)和优良率(BBPS≥8分)分别为94.7%(142/150)、62.7%(94/150)，均显著高于B组的79.3%(119/150)和38.0%(57/150)(

0.01)；A组总体不良反应发生发生率为14.0%(21/150)显著低于B组的32.0%(

0.01)。

结论

3 L低浓度PEG分阶段口服方案具有较好的肠道清洁效果且副作用发生率相对较低。

Abstract

Objective

To evaluate the effect and adverse reactions of staged oral administration of low-concentration polyethylene glycol electrolyte (PEG) solution in a volume of 3 L for intestinal preparation before colonoscopy.

Methods

From February 1

2017 to May 31

2017

300 patients undergoing elective colonoscopy in our department were randomized for bowel preparation with either staged oral administration of 3 L low-concentration PEG solution (group A) or with one-stage oral administration of 2 L PEG solution at the conventional concentration (group B). The colonoscopists and nurses

who were blinded to the randomization of the patients

assessed the Boston intestinal preparation score (BBPS) and recorded the occurrence of adverse reactions in the patients.

Results

The average age

gender ratio

height

body weight and education level were all similar between the 2 groups (

0.05). In group A

the rates of good bowel preparation effect (BBPS≥5) and excellent effect (BBPS≥8) were 94.6% (142/150) and 62.7% (94/150)

significantly higher than the rates of 79.3% (119/150) and 38.0% (57/150) in group B

respectively (

0.01). Adverse reactions occurred in 14.0% (21/150) of the patients in group A

a rate significantly lower than that in group B (32.0%

0.01).

Conclusion

Staged oral administration of 3 L low-concentration PEG solution produces bet-ter bowel cleaning effect with lowered adverse reactions compared with the conventional bowel preparation method.

关键词

Keywords

references

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