Assessment of chronic stress and its association with prognosis in hepatocellular carcinoma patients

Hongbo HUAN; Lili WU; Xudong WEN; Liang ZHANG; Dapeng YANG; Xishu WANG; Yongrong LEI; Peng JIANG; Feng XIA

doi:10.16016/j.1000-5404.201711029

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Assessment of chronic stress and its association with prognosis in hepatocellular carcinoma patients

Clinical Medicine | 更新时间：2026-01-09

- Assessment of chronic stress and its association with prognosis in hepatocellular carcinoma patients
- Journal of Third Military Medical University Vol. 40, Issue 9, Pages: 816-822(2018)
- 作者机构：
  
  1.400038 重庆, 陆军军医大学(第三军医大学)第一附属医院全军肝胆外科研究所
  2.100048 北京, 解放军总医院第一附属医院普外科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201711029
  CLC： R195.4;R331.31;R735.7
- Received：06 November 2017，
  
  Revised：2018-02-05，
  
  Published：15 May 2018
- 稿件说明：
移动端阅览
Hongbo HUAN, Lili WU, Xudong WEN, et al. Assessment of chronic stress and its association with prognosis in hepatocellular carcinoma patients[J]. Journal of Third Military Medical University, 2018, 40(9): 816-822.
DOI：

Hongbo HUAN, Lili WU, Xudong WEN, et al. Assessment of chronic stress and its association with prognosis in hepatocellular carcinoma patients[J]. Journal of Third Military Medical University, 2018, 40(9): 816-822. DOI： 10.16016/j.1000-5404.201711029.

摘要

目的

检测肝癌患者心率变异(heart rate variability

HRV)和应激指数水平

探索评估肝癌患者慢性应激水平的方法

初步探讨肝癌患者慢性应激状态与预后的相关性。

方法

收集41例肝癌患者

利用HRV检测仪分别在术后5 d

3、6个月检测患者应激指数和HRV指标R-R间期标准差(standard deviations of normal-to-normal R-R intervals

SDNN)、相邻R-R间期差值的均方根(root mean square standard deviations of R-R intervals

RMSSD)、低频功率(low frequency

LF)、高频功率(high frequency

HF)的水平; 分析HRV各指标与应激指数的相关性; 并研究各应激指标与患者生存时间的关系。

结果

HRV 4个指标分别与应激指数呈显著负相关(SDNN、RMSSD、LF、HF的

分别为-0.703、-0.674、-0.508、-0.707

0.01)。应激指数和HRV指标分别与肝癌患者预后相关:应激指数高水平(≥52)的患者无疾病生存期和总生存期均较低水平组(

52)明显缩短(

0.01)。HRV 4个指标SDNN、RMSSD、LF、HF低水平的患者无疾病生存期分别较高水平组短(SDNN、RMSSD

0.01;LF、HF

0.05)。4个HRV指标低水平组患者总生存期也较高水平组显著缩短(SDNN

0.05;RMSSD、LF、HF

0.01)。进一步分析发现应激指数和SDNN与肝癌患者术后复发情况明显相关(

=0.024

=0.021)。

结论

HRV水平较低的肝癌患者应激指数为高水平

这些应激指标能够评估患者慢性应激水平

证实慢性应激水平较高的肝癌患者术后复发率较高

总生存时间亦较短。

Abstract

Objective

To evaluate chronic stress by detecting heart rate variability (HRV) and stress index in the patients with hepatocellular carcinoma (HCC)

and primarily investigate the correlation of chronic stress and prognosis of HCC patients.

Methods

A total of 41 HCC patients undergoing total hepatectomy in First Affiliated Hospital of Army Medical University during 2012 to 2016 were enrolled in this study.Body-Checker device was used to detect the stress index

standard deviations of normal-to-normal R-R intervals (SDNN)

root mean square standard deviations of R-R intervals (RMSSD)

low frequency (LF) and high frequency (HF).The correlation of HRV indicators and stress index

and the relationship of stress indicators with survival time were analyzed.

Results

The 4 HRV indicators were negatively correlated with stress index respectively (SDNN:

=-0.703

RMSSD:

=-0.674

LF:

=-0.508

HF:

=-0.707

all

0.01).Stress index and HRV indicators were all related to the prognosis of HCC patients.The patients with high-level stress index (≥52) had shorter disease free survival (DFS) and overall survival (OS) than those with low-level (

52) (all

0.01).The DFS of the patients with low-level HRV were shorter than the high-level group (SDNN and RMSSD:

0.01;LF and HF:

0.05).The patients with low-level HRV had shorter OS than those with high-level (SDNN:

0.05;RMSSD

LF and HF:

0.01).Further analysis indicated that stress index and SDNN were significantly correlated to the recurrence of HCC (

=0.024

=0.021).

Conclusion

The HCC patients with low-level HRV have high stress indexes

which are effective in assessment of chronic stress.The patients with high-level chronic tress are prone to recurrence of HCC and to having shorter OS.

关键词

Keywords

references

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