Efficacy of mechanical thrombectomy with stent retriever for moderate to severe in-hospital acute ischemic stroke patients

Shan WEN; Shugui SHI; Zhenhua ZHOU; Guangjian LI; Hong ZHAI; Lin CHEN; Yi WANG; Long LU; Pei JIANG; Jun HU

doi:10.16016/j.1000-5404.201710122

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Efficacy of mechanical thrombectomy with stent retriever for moderate to severe in-hospital acute ischemic stroke patients

Basic Medicine | 更新时间：2026-01-09

- Efficacy of mechanical thrombectomy with stent retriever for moderate to severe in-hospital acute ischemic stroke patients
- Journal of Third Military Medical University Vol. 40, Issue 6, Pages: 507-512(2018)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院神经内科
- 作者简介：
- 基金信息：
  
  the Project of Major New Technology for Southwest Hospital Informatization (Wisdom Medicine)(SWH2016ZDCX4301)
- DOI：10.16016/j.1000-5404.201710122
  CLC： R181.32;R741.05;R743.3
- Received：19 October 2017，
  
  Revised：2017-12-01，
  
  Published：30 March 2018
- 稿件说明：
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Shan WEN, Shugui SHI, Zhenhua ZHOU, et al. Efficacy of mechanical thrombectomy with stent retriever for moderate to severe in-hospital acute ischemic stroke patients[J]. Journal of Third Military Medical University, 2018, 40(6): 507-512.
DOI：

Shan WEN, Shugui SHI, Zhenhua ZHOU, et al. Efficacy of mechanical thrombectomy with stent retriever for moderate to severe in-hospital acute ischemic stroke patients[J]. Journal of Third Military Medical University, 2018, 40(6): 507-512. DOI： 10.16016/j.1000-5404.201710122.

摘要

目的

探讨支架取栓术对伴有颅内外大血管病变的中重度院内急性缺血性卒中的疗效。

方法

回顾性分析2012年9月至2017年5月在我院发生的、伴有颅内外大血管病变的中重度缺血性卒中患者的临床资料，其中12例行支架取栓治疗，15例行单纯药物治疗。对比支架取栓治疗与单独药物治疗前后美国国立卫生研究院卒中量表(national institutes of health stroke scale，NIHSS)评分下降程度，评估3个月时改良RANKIN量表(mRS)评分，对比分析两组患者的疗效。

结果

共纳入患者27例，其中12例进行了支架取栓治疗

术前NIHSS评分为(18.9±6.3)分，术后7 d NIHSS评分为(10.6±7.5)分，差异有统计学意义(

＜0.05)；单纯药物治疗组用药前NIHSS评分为(12.7±4.2)分，治疗7 d时NIHSS评分为(9.4±6.1)分，差异有统计学意义(

＜0.05)。支架取栓组血管完全再通[脑梗死溶栓分级(thrombolysis in myocardial infarction

TICI)2b~3级

]

10例，部分再通(TICI 2a级)1例，未成功再通(TICI 0~1级)1例。术后3个月功能预后良好(mRS评分为0~2分)：支架取栓组7例(占58.3%)，单纯药物治疗组3例(占20.0%)，2组差异有统计学意义(

＜0.05)。

结论

支架取栓治疗可明显增加伴有大血管病变的中重度院内缺血性卒中患者的血运重建率，降低患者的致残率，促进患者神经功能恢复。

Abstract

Objective

To investigate the efficacy of mechanical thrombectomy with stent retriever for moderate to severe acute ischemic stroke patients hospitalized due to intracranial and extracranial large artery disease.

Methods

We retrospectively analyzed angiographic and clinical data from 27 consecutive moderate to severe in-hospital ischemic stroke patients who admitted in our hospital due to intracranial and extracranial large artery disease between September 2012 and May 2017. Mechanical thrombectomy was performed in 12 patients

and the other 15 patients only received medication treatment. The scores of National Institutes of Health Stroke Scale (NIHSS) before and after treatment were compared

and the difference was compared between the 2 approaches. The modified Rankin Scale (mRS) was employed to evaluate the efficacy of mechanical thrombectomy and drug treatment in 3 months later.

Results

In the 12 patients undergoing mechanical thrombectomy

the NIHSS score was decreased from 18.9±6.3 before operation to 10.6±7.5 in 7 d after (

＜0.05)

and 10 of them obtained complete recanalization (thrombolysis in myocardial infarction

TICI 2b~3)

and 1 only got partially recanalized (TICI 2a)

and 1 failed (TICI 0~1). In 3 months after treatment

there were 7 patients (58.3%) from mechanical thrombectomy group achieving sound functional independence (mRS 0~2)

while only 3 cases (20%) in the medication group

with significant difference between the 2 groups (

＜0.05).

Conclusion

For the moderate to severe in-hospital ischemic stroke patients caused by large artery disease

mechanical thrombectomy with stent retriever can increase revascularization

reduce disability and promote the recovery of nerve function.

关键词

Keywords

references

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