Correlation between plaques at different sites in the carotid arteries and risks of coronary heart disease

Benna ZHANG; Jia JIA; Zhike LIU; Jianping LI; Yong HUO; Dafang CHEN; Yan ZHANG; Qingying TONG

doi:10.16016/j.1000-5404.201708120

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Correlation between plaques at different sites in the carotid arteries and risks of coronary heart disease

Clinical Medicine | 更新时间：2026-01-09

- Correlation between plaques at different sites in the carotid arteries and risks of coronary heart disease
- Journal of Third Military Medical University Vol. 40, Issue 2, Pages: 160-164(2018)
- 作者机构：
  
  1.121001 辽宁锦州，锦州医科大学
  2.100034 北京，北京大学第一医院心内科
  3.100191 北京，北京大学公共卫生学院
  4.100039 北京，武警总医院医学工程科
- 作者简介：
- 基金信息：
  
  the UM-PUHSC Joint Institute for Translational and Clinical Research(BMU20110177)
- DOI：10.16016/j.1000-5404.201708120
  CLC： R181.32;R541.4;R543.4
- Received：19 August 2017，
  
  Revised：2017-11-06，
  
  Published：30 January 2018
- 稿件说明：
移动端阅览
Benna ZHANG, Jia JIA, Zhike LIU, et al. Correlation between plaques at different sites in the carotid arteries and risks of coronary heart disease[J]. Journal of Third Military Medical University, 2018, 40(2): 160-164.
DOI：

Benna ZHANG, Jia JIA, Zhike LIU, et al. Correlation between plaques at different sites in the carotid arteries and risks of coronary heart disease[J]. Journal of Third Military Medical University, 2018, 40(2): 160-164. DOI： 10.16016/j.1000-5404.201708120.

摘要

目的

探讨颈动脉不同部位斑块与冠心病的关系，为预防冠心病提供科学依据。

方法

采用横断面研究设计，对北京市石景山区古城社区和苹果园社区40岁及以上的社区居民进行一般人口学资料问卷调查、体格检查、生化指标检测以及颈动脉超声检查; 采用非条件Logistic回归分析不同部位的颈动脉斑块与冠心病的关系。

结果

共纳入3 840名研究对象，其中冠心病组481名(12.6%)，非冠心病组3 349(87.4%)。Logistic回归分析显示，调整年龄、性别、体质指数、文化程度、吸烟、饮酒、高血压、2型糖尿病、高血脂、血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、降压药物、降糖药物因素后，颈总动脉、颈动脉膨大部、颈内动脉，斑块检出者均比未检出者患冠心病风险高[(

=1.486

95%

：1.122~1.968)、(

=1.501，95%

：1.183~1.904)、(

=1.566，95%

：1.213~2.022)

]

; 颈总动脉、颈动脉膨大部、颈内动脉每增加一个斑块，冠心病风险分别增加26.5%(

=1.265，95%

：1.083~1.478)、24.7%(

=1.247，95%

：1.120~1.390)、30.5%(

=1.305，95%

：1.102~1.546)

颈内动脉斑块总面积每增加1mm

，冠心病患病风险增加1.6%

(

=1.016，95%

：1.005~1.027);斑块病变部位与冠心病的患病风险之间存在剂量-反应关系(线性趋势检验

0.001)。

结论

颈动脉不同部位的斑块与冠心病存在关联关系，且颈内动脉斑块与冠心病最具有关联性，颈动脉斑块病变部位数增加提示冠心病的患病风险增加。

Abstract

Objective

To explore the relationship between the presence of carotid plaques at different sites and the risks of coronary heart disease (CHD).

Methods

This cross-sectional study was conducted among residents from Gucheng and Pingguoyuan Communities of Shijingshan District

Beijing

China. The residents were asked to complete a questionnaire survey to collect the general data including gender

age

smoking

alcohol consumption

hypertension

hyperlipemia

type 2 diabetes mellitus

coronary heart disease

stroke and other medical conditions. Standardized

Methods

were used for physical examination

laboratory tests

and carotid artery ultrasonography. The relationship between carotid plaques at different sites and CHD was analyzed using non-conditional logistic regression.

Results

A total of 3 840 participants were enrolled in this study

including 481 (12.6%) with CHD and 3 349 (87.4%) without CHD. After adjustment for age

gender

body mass index (BMI)

education

smoking

drinking

hypertension

type 2 diabetes

hyperlipidemia

HDL-C

and the use of antihypertensive drugs and hypoglycemic agents

the patients with CHD were found to have significantly higher detection rates of plaques in the common carotid artery (

=1.486

95%

: 1.122~1.968)

carotid bulb (

=1.501

95%

: 1.183~1.904)

and internal carotid artery (

=1.566

95%

: 1.213-2.022) than the participants without CHD; the plaques at these 3 sites were associated with increased risks of CHD by 26.5% (

=1.265

95%

: 1.083~1.478)

24.7% (

=1.247

95%

: 1.120~1.390)

and 30.5% (

=1.305

95%

: 1.102~1.546)

respectively. An increase by 1 mm

of the total plaque area in the internal carotid artery was associated with an increase of the risk of CHD by 1.6% (

=1.016

95%

: 1.005~1.027);

dose-response relationship was found between the sites of plaques in the carotid arteries and the risk of CHD (

0.001 for the linear trend).

Conclusion

The plaques at different sites in the carotid arteries are associated with the risk of CHD. The presence of plaques in the internal carotid artery is most strongly associated with the risk of CHD

and an increase of the lesion site indicates an increased risk of CHD.

关键词

Keywords

references

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