Changes of adipokine levels and their effect on ventricular remodeling in chronic congestive heart failure patients in hypoxic condition

Yan MEI; Aiqi XI; Baoxia LIAO; Ling SHANG

doi:10.16016/j.1000-5404.201708045

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Changes of adipokine levels and their effect on ventricular remodeling in chronic congestive heart failure patients in hypoxic condition

Clinical Medicine | 更新时间：2026-01-09

- Changes of adipokine levels and their effect on ventricular remodeling in chronic congestive heart failure patients in hypoxic condition
- Journal of Third Military Medical University Vol. 39, Issue 23, Pages: 2299-2302(2017)
- 作者机构：
  
  1.810016 西宁，青海大学研究生院临床医学系
  2.810007 西宁，青海省人民医院干部保健科
- 作者简介：
- 基金信息：
  
  the Project of Science and Technology Plan of Qinghai Province(2013-T-Y30)
- DOI：10.16016/j.1000-5404.201708045
  CLC： R339.54;R363.21;R541.6
- Received：08 August 2017，
  
  Revised：2017-09-28，
  
  Published：15 December 2017
- 稿件说明：
移动端阅览
Yan MEI, Aiqi XI, Baoxia LIAO, et al. Changes of adipokine levels and their effect on ventricular remodeling in chronic congestive heart failure patients in hypoxic condition[J]. Journal of Third Military Medical University, 2017, 39(23): 2299-2302.
DOI：

Yan MEI, Aiqi XI, Baoxia LIAO, et al. Changes of adipokine levels and their effect on ventricular remodeling in chronic congestive heart failure patients in hypoxic condition[J]. Journal of Third Military Medical University, 2017, 39(23): 2299-2302. DOI： 10.16016/j.1000-5404.201708045.

摘要

目的

观察低氧环境下慢性心力衰竭(chronic heart faiture

CHF)患者脂肪因子趋化素(chemerin)、瘦素(leptin)、脂联素(adiponectin)水平的变化及对心室构型的影响。

方法

选择收住我科按美国纽约心脏病协会心功能分级标准确诊的CHF患者，按生活的海拔区分为2 260 m组CHF患者、健康对照组各67例和3 300 m组CHF患者、对照组各62例。检测血浆脂联素、趋化素、瘦素水平，计算平均室壁应力(mean wall stress，MWS)和心室质量指数(left ventricular mass index，LVMI)。

结果

海拔3 300 m组CHF患者和健康对照组脂联素、趋化素、瘦素水平和MWS、LVMI均高于2 260 m组(

0.01)；同一海拔高度CHF患者脂联素、趋化素、瘦素水平和MWS、LVMI高于健康对照组；MWS和LVMI与脂联素、趋化素、瘦素水平均呈正相关(

0.01)。

结论

低氧环境下CHF患者脂肪因子脂联素、趋化素、瘦素水平的变化参与了CHF发生、发展的病理生理过程。

Abstract

Objective

To observe the changes of chemerin

leptin

adiponectin levels in chronic heart failure (CHF) patients living in hypoxic regions and investigate their effect on ventricular remodeling.

Methods

Totally 129 CHF patients diagnosed by the New York Heart Association (NYHA) criteria admitted to our department from May 2013 to December 2015 were enrolled in this study. According to the altitude they resided

they were divided into

the 2 260 meters group (

=67) and the 3 300 meters group (

=62). Another 67 and 62 healthy individuals who were residents of similar altitudes respectively served as normal control. The levels of plasma chemerin

leptin

and adiponectin were measured

and the mean wall stress (MWS) and left ventricular mass index (LVMI) were calculated.

Results

The levels of chemerin

leptin

adiponectin

MWS and LVMI were significantly higher in the healthy individuals and CHF patients at 3 300 meters than those at 2 260 meters above sea level (

0.01). The above indicators were also obviously higher in the CHF patients than the healthy subjects living at the same regions. Chemerin

leptin and adiponectin levels were positively correlated with MWS and LVMI (

0.01).

Conclusions

Adipokines chemerin

leptin and adiponectin take part in the pathogenesis of CHF in the patients living in hypoxic regions.

关键词

Keywords

references

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