Relationship between seizure-onset patterns of scalp EEG and epileptogenic lesions in intractable temporal lobe epilepsy

Yuan TAO; Wei DAN; Chao ZHOU; Chao SUN; Yanfeng XIE; Quanhong SHI; Yan ZHAN

doi:10.16016/j.1000-5404.201707124

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Relationship between seizure-onset patterns of scalp EEG and epileptogenic lesions in intractable temporal lobe epilepsy

Clinical Medicine | 更新时间：2026-01-09

- Relationship between seizure-onset patterns of scalp EEG and epileptogenic lesions in intractable temporal lobe epilepsy
- Journal of Third Military Medical University Vol. 39, Issue 22, Pages: 2220-2225(2017)
- 作者机构：
  
  400016 重庆，重庆医科大学附属第一医院神经外科
- 作者简介：
- 基金信息：
  
  the Key Project of Chongqing Municipal Health Bureau(2012-1-008);the National Clinical Key-discipline Construction Program of China((2011)170号)
- DOI：10.16016/j.1000-5404.201707124
  CLC： R181.32;R741.044;R742.1
- Received：19 July 2017，
  
  Revised：2017-09-20，
  
  Published：30 November 2017
- 稿件说明：
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Yuan TAO, Wei DAN, Chao ZHOU, et al. Relationship between seizure-onset patterns of scalp EEG and epileptogenic lesions in intractable temporal lobe epilepsy[J]. Journal of Third Military Medical University, 2017, 39(22): 2220-2225.
DOI：

Yuan TAO, Wei DAN, Chao ZHOU, et al. Relationship between seizure-onset patterns of scalp EEG and epileptogenic lesions in intractable temporal lobe epilepsy[J]. Journal of Third Military Medical University, 2017, 39(22): 2220-2225. DOI： 10.16016/j.1000-5404.201707124.

摘要

目的

观察难治性颞叶癫痫(intractable temporal lobe epilepsy

ITLE)患者头皮脑电发作起始形式，并探讨其与致痫病变的关系。

方法

回顾性分析我院神经外科2011年9月至2015年9月45例ITLE患者的临床信息及其172次临床发作的视频脑电图资料，所有病例行切除性癫痫手术治疗，术后效果评估均为EngelⅠ级。根据术前MRI所示致痫病变部位的不同分为颞叶内侧癫痫(mesial temporal lobe epilepsy

MTLE)和颞叶新皮层癫痫(neocortical temporal lobe epilepsy

NTLE)；术后病检可见6种不同病理类型。对发作期脑电起始形式进行分析，比较各种起始形式在不同部位及不同性质致痫病变的出现差异，探讨不同发作起始形式对致痫灶的定位价值及可能的神经电生理机制。

结果

① 45例患者172次临床发作期脑电中有明显起始形式157次，包括低幅快活动(low-voltage fast activity

LVFA)57次(36.3%)，θ节律35次(22.3%)，δ活动31次(19.7%)，尖波活动20次(12.7%)，低中幅多棘波14次(8.9%)。157次发作期脑电中局灶性起源103次(65.6%)，LVFA占49次(47.6%)，LVFA的定位率明显高于其他起始形式(

0.01)。② 5种起始形式均可见于MTLE和NTLE，LVFA在NTLE的出现率明显高于MTLE(

0.01)，慢活动(θ节律及δ活动)在MTLE的出现率高于NTLE(

0.05)，尖波活动及低中幅多棘波在不同部位的出现差异无统计学意义(

0.05)。③5种起始形式可见于不同性质的致痫病变，θ节律在海马硬化(hippocampal sclerosis

HS)病变中的出现率高于其他病变类型(

0.05)。

结论

ITLE发作期头皮脑电起始形式中LVFA有较好定位价值，θ节律对HS具有提示意义。

Abstract

Objective

To investigate the relationship between seizure-onset patterns of scalp EEG and epileptogenic lesions in patients with intractable temporal lobe epilepsy (ITLE).

Methods

Between September

2011 and September

2015

45 patients with ITLE were treated in our hospital and their clinical and video EEG (V-EEG; 172 recordings) data were analyzed retrospectively. All the patients underwent surgical resection of the epileptogenic lesions (Engel Grade Ⅰ by postoperative evaluation) and were followed up for at least 1 year. According to the preoperative magnetic resonance imaging (MRI) of the epileptogenic lesions

the patients were divided into mesial temporal lobe epilepsy (MTLE) and neocortical temporal lobe epilepsy (NTLE) groups; 6 different pathological types of the lesions were identified after the surgery. The seizure-onset patterns of the patients were analyzed

and the frequencies of the patterns were compared among patients with lesions at different sites and of different pathological types.

Results

Of the 172 video scalp EEG recordings during clinical onset

obvious seizure-onset patterns were identified in 157 recordings

including 57 (36.3%) showing low-volt

age fast activity (LVFA)

35 showing (22.3%) θ rhythm

31(19.7%) showing δ activity

20 (12.7%) showing sharp wave activity and 14 (8.9%) showing low or moderate amplitude polyspikes. Of the 157 recordings with clear seizure-onset patterns

localized patterns were found in 103 recordings (65.6%) including 49 (47.6%) showing LVFA

whose localization rate was significantly higher than that of other patterns (49/57

54/100

0.01). The 5 seizure-onset patterns were seen in both MTLE and NTLE

but LVFA was more frequently found in NTLE than in MTLE (46/89 vs 11/68

0.01)

and slow activity (θ rhythm and δ activity) was more frequent in MTLE than in NTLE (43/68

23/89

0.05). The frequencies of sharp wave activity and low or moderate amplitude polyspikes were similar between MTLE and NTLE (

0.05). The 5 seizure-onset patterns were found in cases of epileptogenic lesions of different pathological types

and θ rhythm was more frequently found in hippocampal sclerosis than in other lesions (16/45

19/112

0.05).

Conclusion

In patients with ITLE

ictal scalp EEG may present different seizure-onset patterns

among which LVFA has a good value in localizing the lesions

and θ rhythm can be indicative of hippocampal sclerosis.

关键词

Keywords

references

BEGHI E, BERG A, CARPIO A, et al . Comment on epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy(ILAE) and the International Bureau for Epilepsy(IBE)[J ] . Epilepsia, 2005, 46(10): 1698-1699. DOI: 10.1111/j.1528-1167.2005.00273_1.x.

HAERIAN B S, ROSLAN H, RAYMOND A A, et al . ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta analysis[J ] . Seizure, 2010, 19(6):339-346. DOI: 10.1016/j.seizure.2010.05.004.

ZAATREH M M, FIRLIK K S, SPENCER D D, et al . Temporal lobe tumoral epilepsy: characteristics and predictors of surgical outcome [J ] . Neurology, 2003, 61(5): 636-641. DOI: 10.1212/01.wnl.0000079374.78589.1b.

QUARATO P P, GENNARO G D, MASCIA A, et al . Temporal lobe epilepsy surgery: different surgical strategies after a non-invasive diagnostic protocol [J ] .J Neurol Neurosurg Psychiatry, 2005, 76(6): 815-824. DOI: 10.1136/jnnp.2004.044016.

SERLES W, CARAMANOS Z, LINDINGER G, et al . Combining ictal surface-electroencephalography and seizure semiology improves patient ateralization in temporal lobe epilepsy[J ] . Epilepsia, 2000, 41(12): 1567-1573.

JACOBS J, LEVAN P, CHANDER R, et al . Interictal high-frequency oscillations (80-500Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain[J ] . Epilepsia, 2008, 49(11): 1893-1907. DOI: 10.1111/j.1528-1167.2008.01656.x.

PERUCCA P, DUBEAU F, GOTMAN J. Intracranial electroencephalographic seizure-onset patterns:effect of underlying pathology [J]. Brain, 2014, 137(1): 183-196. DOI: 10.1093/brain/awt299.

MALTER M P, BAHRENBERG C, NIEHUSMANN P, et al . Features of scalp EEG in unilateral mesial temporal lobe epilepsy due to hippocampal sclerosis: Determining factors and predictive value forepilepsy surgery[J ] . Clin Neurophysiol, 2016, 127(2): 1081-1087. DOI: 10.1016/j.clinph.2015.06.035.

PELLICCIA V, MAI R, FRANCIONE S, et al . Ictal EEG modifications in temporal lobe epilepsy[J ] . Epileptic Disord, 2013, 15(4): 392-399. DOI: 10.1684/epd.2013.0615.

冯丽, 丁美萍, 朱君明.颞叶癫痫脑电发作起始形式在癫痫灶定位的价值[J].中山大学学报(医学科学版), 2013, 34(5): 806-810.

FENG L, DING M P, ZHU J M. Evaluation of onset types of ictal eeg for localization of temporal lobe epilepsy[J]. J Sun Yat-sen Univ(Med Sci), 2013, 34(5): 806-810.

FOLDVARY N, KLEM G, HAMMEl J, et al . The localizing value of ictal EEG in focal epilepsy[J ] . Neurology, 2001, 57(11): 2022-2028. DOI: 10.1212/wnl.57.11.2022.

DE CURTIS M, AVOLI M. Initiation, propagation, and termination of partial(focal) seizures[J]. Cold Spring Harb Perspect Med, 2015, 5(7): a022368. DOI: 10.1101/cshperspect.a022368.

BRAGIN A, ENGEL J, STABA R J. High-frequency oscillations in epileptic brain[J]. Curr Opin Neurol, 2010, 23(2): 151-156. DOI: 10.1097/WCO.0b013e3283373ac8.

JIMÉNEZ-JIMÉNEZ D, NEKKARE R, Flores L, et al . Prognostic value of intracranial seizure onset patterns for surgical outcome of the treatment of epilepsy [J ] . Clin Neurophysiol, 2015, 126(2): 257-267. DOI: 10.1016/j.clinph.2014.06.005.

BARTOLOMEI F, CHAUVEL P, WENDLING F. Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG[J]. Brain, 2008, 131(7): 1818-1830. DOI: 10.1093/brain/awn111.

WETJEN N M, MARSH W R, MEYER F B, et al . Intracranial electroencephalography seizure onset patterns and surgical outcomes in nonlesional extratemporal epilepsy[J ] . J Neurosurg, 2009, 110(6): 1147-1152. DOI: 10.3171/2008.8.JNS17643.

BARTOLOMEI F, COSANDIER-RIMÉLÉ D, MCGONIGAL A, et al . From mesial temporal lobe to temporoperisylvian seizures: a quantified study of temporal lobe seizure network [J ] . Epilepsia, 2010, 51(10): 2147-2158. DOI: 10.1111/j.1528-1167.2010.02690.x.

EBERSOLE J S, HUSAIN A M, NORDLI JR D R. Current practice of clinica electroencephalograph[M]. 4th ed. Philadelphia: Wolters Kluwer Health, 2014: 1-4.

EBNER A, HOPPE M. Noninvasive electroencephalography and mesial temporal sclerosis [J]. J Clin Neurophysiol, 1995, 12(1): 23-31.

PITKÄNEN A, LUKASIUK K.Mechanisms of epileptogenesis and potential treatment targets[J]. Lancet Neurol, 2011, 10(2): 173-186. DOI: 10.1016/S1474-4422(10)70310-0.

MOHANRAJ R, BRODIE M J. Outcomes in newly diagnosed localization-related epilepsies[J]. Seizure, 2005, 14(5): 318-323. DOI: 10.1016/j.seizure.2005.04.002.

JACOBS J, LEVAN P, CHÄTILLON C E, et al .High frequency oscillations in intracranial EEGs markepileptogenicity rather than lesion type[J ] . Brain, 2009, 132(4): 1022-1037. DOI: 10.1093/brain/awn351.

COSANDIER-RIMÉLÉ D, BARTOLOMEI F, MERLET I, et al . Recording of fast activity at the onset of partial seizures: depth EEG vs scalp EEG[J ] . Neuroimage, 2012, 59(4): 3474-3487. DOI: 10.1016/j.neuroimage.2011.11.045..

PACIA S V, EBERSOLE J S. Intracranial EEG substrates of scalp ictal patterns from temporal lobe foci[J]. Epilepsia, 1997, 38(6): 642-654. DOI: 10.1111/j.1528-1157.1997.tb01233.x.

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