Effect of high-dose statins in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: a meta-analysis and systematic review

Jie AN; Shengyan WEN; Qiang SHE

doi:10.16016/j.1000-5404.201707018

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Effect of high-dose statins in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: a meta-analysis and systematic review

Clinical Medicine | 更新时间：2026-01-09

- Effect of high-dose statins in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: a meta-analysis and systematic review
- Journal of Third Military Medical University Vol. 39, Issue 23, Pages: 2316-2322(2017)
- 作者机构：
  
  400010 重庆，重庆医科大学附属第二医院心血管内科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201707018
  CLC： R181.23;R542.22;R972.6
- Received：01 July 2017，
  
  Revised：2017-08-29，
  
  Published：15 December 2017
- 稿件说明：
移动端阅览
Jie AN, Shengyan WEN, Qiang SHE. Effect of high-dose statins in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: a meta-analysis and systematic review[J]. Journal of Third Military Medical University, 2017, 39(23): 2316-2322.
DOI：

Jie AN, Shengyan WEN, Qiang SHE. Effect of high-dose statins in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: a meta-analysis and systematic review[J]. Journal of Third Military Medical University, 2017, 39(23): 2316-2322. DOI： 10.16016/j.1000-5404.201707018.

摘要

目的

评价负荷他汀类药物对急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction，STEMI)患者经皮冠状动脉介入(percutaneous coronary intervention，PCI)治疗术后的疗效。

方法

计算机检索PubMed、EMBASE、Cochrane Library等数据库，收集数据库建库至2017年3月的随机对照试验研究。两位评价者独立评价纳入研究质量、提取资料并交叉核对。采用Rev Man 5.3软件进行Meta分析。

结果

共纳入11项RCT研究，合计1 419例患者。PCI术前负荷他汀类药物对心肌梗死溶栓治疗(thrombolysis in myocardial infarction，TIMI)后血流的改善显著高于对照组(

=1.09，95%

：1.05~1.13，

0.01)。负荷组30 d主要心血管不良事件(major adverse cardiovascular events，MACEs)的发生率低于对照组(

=0.50，95%

：0.32~0.79，

0.01)。亚组分析结果显示：PCI术前单次负荷他汀治疗后30

MACEs的发生率(

=0.47，95%

：0.22~1.01，

=0.05)。短期负荷他汀治疗后30

MACEs的发生率(

=0.52，95%

：0.30~0.91，

0.05)。

结论

STEMI患者负荷他汀治疗能改善PCI术后心肌血流灌注，能降低30 dMACEs的发生率。

Abstract

Objective

To determine the effect of high-dose statins in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI).

Methods

PubMed

EMBASE

Cochrane Library

CNKI and SinoMed were searched for randomized controlled trials (RCTs) concerning above subjects and treatments published up to March

2017. Two reviewers independently evaluated the quality of the included studies. Meta-analysis was performed by RevMan 5.3 software.

Results

Eleven RCTs involving 1 419 patients were included. The results showed that high-dose statins significantly improved the final thrombolysis in m

yocardial infarction (TIMI) flow grade after PCI (

=1.09

95%

=1.05~1.13

0.01) and reduced the incidence of major adverse cardiovascular events (MACEs) at 30-day follow-up (

=0.50

95%

=0.32~0.79

0.01). Subgroup analysis indicated that only short-term high-dose statin (

=0.52

95%

=0.30~0.91

0.05) but not single high-dose statin treatment (

=0.47

95%

=0.22~1.01

=0.05) showed priority in decreasing the occurrence of MACEs.

Conclusions

High-dose statins can significantly improve microvascular myocardial perfusion and decrease the incidence of 30-day MACEs in STEMI patients after PCI.

关键词

Keywords

references

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