Effect of ticagrelor on ventricular remodeling in patients with STEMI undergoing emergency PCI

Ling WANG; Langtao GUO; Xuxi HONG

doi:10.16016/j.1000-5404.201705021

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Effect of ticagrelor on ventricular remodeling in patients with STEMI undergoing emergency PCI

Clinical Medicine | 更新时间：2026-01-09

- Effect of ticagrelor on ventricular remodeling in patients with STEMI undergoing emergency PCI
- Journal of Third Military Medical University Vol. 39, Issue 21, Pages: 2126-2130(2017)
- 作者机构：
  
  362000 福建泉州，福建医科大学附属泉州第一医院心内科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201705021
  CLC： R540.45;R542.22;R973.2
- Received：04 May 2017，
  
  Revised：2017-07-12，
  
  Published：15 November 2017
- 稿件说明：
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Ling WANG, Langtao GUO, Xuxi HONG. Effect of ticagrelor on ventricular remodeling in patients with STEMI undergoing emergency PCI[J]. Journal of Third Military Medical University, 2017, 39(21): 2126-2130.
DOI：

Ling WANG, Langtao GUO, Xuxi HONG. Effect of ticagrelor on ventricular remodeling in patients with STEMI undergoing emergency PCI[J]. Journal of Third Military Medical University, 2017, 39(21): 2126-2130. DOI： 10.16016/j.1000-5404.201705021.

摘要

目的

探讨ST段抬高型心肌梗死(ST-segment elevation myocardial infarction，STEMI)行急诊经皮冠脉介入术(percutaneous coronary intervention，PCI)患者加用替格瑞洛治疗的临床效果及对患者心室重构的影响。

方法

选取我院急诊PCI手术治疗的STEMI患者120例(2014年1月至2016年8月)进行回顾性分析，患者均急诊PCI手术，根据治疗药物分为两组，60例患者术前及术后均给予替格瑞洛(替格瑞洛组)、60例患者术前及术后均给予氯吡格雷(氯吡格雷组)，对比两组患者术后心室重构指标、心电图等指标。

结果

术后12周，替格瑞洛组LVEDd(49.1±5.4)mm、LVESD(40.6±4.6)mm、LVMI(112.8±11.0)g/m

、LVMW(140.7±18.5)g低于氯吡格雷组患者LVEDd(53.1±4.6)mm、LVESD(43.9±4.7)mm、LVMI(118.2±9.4)g/m

、LVMW(153.0±21.3)g(

=4.638、

=3.887、

=2.891、

=2.198，

均

0.05)，两组患者的LVEF值差异无统计学意义(

=1.064，

0.05)；术后12周，替格瑞洛组Tp-e(114.2±12.7)ms、Tp-e/QTc(0.20±0.05)低于氯吡格雷组患者Tp-e(120.6±13.9)ms、Tp-e/QTc(0.25±0.07)(

=2.633、

=4.502，

0.05)；替格瑞洛组的不良心血管事件发生率6.67%与氯吡格雷组的13.33%比较，差异无统计学意义(χ

=1.481，

0.05)。

讨论

STEMI行PCI患者加用替格瑞洛治疗能有效减轻心室重构，改善心电图指标。

Abstract

Objective

To investigate the clinical efficacy of ticagrelor in treatment of ST-segment elevation myocardial infarction (STEMI) patients before and after emergency percutaneous coronary intervention (PCI)

and determine its effect on the ventricular remodeling.

Methods

A retrospective analysis was conducted on 120 STEMI patients who underwent emergency PCI in our hospital from January 2014 to August 2016. According to their drug treatment

they were divided into ticagrelor group (

=60

given ticagrelor pre-and post-operatively) and clopidogrel group (

=60

given clopidogrel pre-and post-operatively). The ind

exes of ventricular remodeling

electrocardiography (ECG) parameters and other indexes were compared between the 2 groups.

Results

In 12 weeks after operation

the ticagrelor group had significantly lower left ventricular end diastolic diameter (LVEDd

49.1±5.4

53.1±4.6 mm

=4.638

0.05)

left ventricular end systolic diameter (LVESD

40.6±4.6

43.9±4.7 mm

=3.887

0.05)

left ventricular mass index (LVMI

112.8±11.0

118.2±9.4 g/m

=2.891

0.05)

and left ventricular mass (LVMW

140.7±18.5

153±21.3 g

=2.198

0.05) when compared with the clopidogrel group. But no difference was seen in left ventricular ejection fraction (LVEF) between them (

=1.064

0.05). What's more

the T wave (Tp-e) interval and the Tp-e/QT ratio were obviously lower in the ticagrelor group than the other group (114.2±12.7

120.6±13.9 ms

=2.633

0.05; 0.20±0.05

0.25±0.07

=4.502

0.05). There was no notable difference in the incidence of adverse cardiovascular events between them (6.67%

13.33%

Chi

-square=1.481

0.05).

Conclusion

Additional ticagrelor treatment can effectively reduce ventricular remodeling and improve ECG indicators in STEMI patients undergoing PCI.

关键词

Keywords

references

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