Terahertz spectroscopy for lung cancer detection: a preliminary study

Dingyuan LIU; Changcheng SHI; Xiangdong ZHOU

doi:10.16016/j.1000-5404.201702014

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Terahertz spectroscopy for lung cancer detection: a preliminary study

Clinical Medicine | 更新时间：2026-01-09

- Terahertz spectroscopy for lung cancer detection: a preliminary study
- Journal of Third Military Medical University Vol. 39, Issue 17, Pages: 1739-1743(2017)
- 作者机构：
  
  1.400038 重庆，第三军医大学西南医院呼吸内科
  2.400714 重庆，中国科学院重庆绿色智能技术研究院
- 作者简介：
- 基金信息：
  
  Supported by the Incubation Fund of Cross-discipline Laboratory of Engineering Physics and Biomedicine (2010)
- DOI：10.16016/j.1000-5404.201702014
  CLC： O433.4;R730.49;R734.2
- Received：05 February 2017，
  
  Revised：2017-05-01，
  
  Published：15 September 2017
- 稿件说明：
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Dingyuan LIU, Changcheng SHI, Xiangdong ZHOU. Terahertz spectroscopy for lung cancer detection: a preliminary study[J]. Journal of Third Military Medical University, 2017, 39(17): 1739-1743.
DOI：

Dingyuan LIU, Changcheng SHI, Xiangdong ZHOU. Terahertz spectroscopy for lung cancer detection: a preliminary study[J]. Journal of Third Military Medical University, 2017, 39(17): 1739-1743. DOI： 10.16016/j.1000-5404.201702014.

摘要

目的

利用太赫兹光谱技术，对人肺癌组织进行检测，比较肺癌组织、癌旁组织及正常肺组织之间的差异，筛选出具有特异性诊断价值的太赫兹频段，初步探索太赫兹光谱技术用于肺癌的早期检测。

方法

收集2015年6月至2015年12月经我院胸外科手术切除、病理明确诊断为Ⅰ~ⅢA期非小细胞肺癌患者30例，其肺癌组织病理类型为：腺癌17例、鳞癌10例、大细胞肺癌2例、肉瘤样癌1例。每组包括同一患者肺癌组织、癌旁组织及正常肺组织。运用频段为0.2~2.0 THz的太赫兹光谱进行检测，对比3类组织标本对太赫兹光谱的吸收率。

结果

① 肺癌组织对太赫兹光谱吸收率显著高于正常肺组织；② 太赫兹光谱频段1.4~2.0 THz可能为具有肺癌特异性诊断价值的太赫兹频段。

结论

鉴于肺癌组织对太赫兹光谱吸收率高于正常肺组织，太赫兹光谱技术可能成为一种新型非侵入诊断肺癌的检测技术，其具有特异性诊断价值的太赫兹频段可能为1.4~2.0 THz。

Abstract

Objective

To preliminarily explore the application of terahertz spectroscopy in the early detection of lung cancer by comparing the differences among lung cancer tissues

paracancerous tissues

and normal lung tissues with terahertz spectroscopy and screen the suitable terahertz frequency for specific diagnosis of lung cancer.

Methods

Thirty groups of lung tissue samples from non-small cell lung cancer patients at stage of Ⅰ to ⅢA were collected

and each group contained lung cancer tissue

paracancerous tissues

and normal lung tissue from the same patient. These lung cancer specimens included 17 cases of adenocarcinoma

10 cases of squamous cell carcinoma

2 cases of large cell lung cancer

and 1 case of sarcomatoid carcinoma. Terahertz spectroscopy from 0.2 THz to 2.0 THz was used to detect these tissue samples

and the absorption coefficient was compared.

Results

① The absorption coefficient was significantly higher in the lung cancer tissues than the normal lung tissues. ② Terahertz spectroscopy at a frequency of 0.8 to 1.4 THz may have the specific diagnostic value of lung cancer.

Conclusion

Since the absorption rate is higher in the lung cancer than the normal lung tissue

which is suggested that terahertz spectroscopy may be regarded as a novel non-invasive diagnostic approach for lung cancer. The specific diagnostic value of the terahertz frequency may be 1.4-2.0 THz for lung cancer.

关键词

Keywords

references

PARKIN D M, PISANI P, FERLAY J. Global cancer statistics[J]. CA Cancer J Clin, 1999, 49(1): 33-64, 1. DOI:10.3322/canjclin.49.1.33.

刘毅, 初向阳.多原发非小细胞肺癌诊断、治疗及预后的系统性综述[J].解放军医学院学报, 2016, 37(8): 901-904. DOI: 10.3969/j.issn.2095-5227.2016.08.022.

LIU Y, CHU X Y. Diagnosis, treatment and prognosis of patients with multiple primary non small cell lung cancer: A systematic review [J]. Acad J Chin PLA Med School, 2016, 37(8): 901-904. DOI: 10.3969/j.issn.2095-5227.2016.08.022.

DAVIES G, LINFIELD E. Bridging the terahertz gap[J]. Physics World, 2004, 17(4): 37-41. DOI:10.1088/2058-7058/17/4/34.

FERGUSON B, 张希成.太赫兹科学与技术研究回顾[J].物理, 2003, 32(05), 0-0. DOI: 10.3321/j.issn:0379-4148.2003.05.002.

FERGUSON B, ZHANG X C. Materials for terahertz science and technology[J]. Physics, 2003, 32(05), 0-0. DOI: 10.3321/j.issn:0379-4148.2003.05.002.

OH S J, KANG J, MAENG I, et al. Nanoparticle-enabled terahertz imaging for cancer diagnosis[J]. Opt Express, 2009, 17(5): 3469-3475. DOI:10.1364/oe.17.003469.

MENG K, CHEN T N, CHEN T, et al. Terahertz pulsed spectroscopy of paraffin-embedded brain glioma[J]. J Biomed Opt, 2014, 19(7): 077001. DOI:10.1117/1.JBO.19.7.077001.

TRUONG B C, TUAN H D, FITZGERALD A J, et al. Breast cancer classification using extracted parameters from a terahertz dielectric model of human breast tissue[J]. Conf Proc IEEE Eng Med Biol Soc, 2015, 2015: 2804-2807. DOI:10.1109/EMBC.2015.7318974.

WAHAIA F, VALUSIS G, BERNARDO L M, et al. Detection of colon cancer by terahertz techniques[J]. Journal of Molecular Structure, 2011, 1006(1-3):77-82.

WAHAIA F, VALUSIS G, BERNARDO L M, et al. Detection of colon cancer by terahertz techniques[J]. Journal of Molecular Structure, 2011, 1006(1-3):77-82.DOI: org/10.1016/j.molstruc.2011.05.049.

MIURA Y, KAMATAKI A, UZUKI M, et al. Terahertz-wave spectroscopy for precise histopathological imaging of tumor and non-tumor lesions in paraffin sections[J]. Tohoku J Exp Med, 2011, 223(4): 291-296. DOI:10.1620/tjem.223.291.

RAHMAN A, RAHMAN A K, RAO B. Early detection of skin cancer via terahertz spectral profiling and 3D imaging[J]. Biosens Bioelectron, 2016, 82: 64-70. DOI: 10.1016/j.bios.2016.03.051.

YU C, FAN S, SUN Y, et al. The potential of terahertz imaging for cancer diagnosis: a review of investigations to date[J]. Quant Imaging Med Surg, 2012, 2(1): 33-45. DOI:10.3978/j.issn.2223-4292.2012.01.04.

FITZGERALD A J, BERRY E, ZINOV'EV N N, et al. Catalogue of human tissue optical properties at terahertz frequencies[J]. J Biol Phys, 2003, 29(2-3): 123-128. DOI:10.1023/A:1024428406218.

JOSEPH C S, YAROSLAVSKY A N, NEEL V A, et al. Continuous wave terahertz transmission imaging of nonmelanoma skin cancers[J]. Lasers Surg Med, 2011, 43(6): 457-462. DOI:10.1002/lsm.21078.

ASHWORTH P C, PICKWELL-MACPHERSON E, PROVENZANO E, et al. Terahertz pulsed spectroscopy of freshly excised human breast cancer[J]. Opt Express, 2009, 17(15): 12444-12454. DOI:10.1364/oe.17.012444.

BRUEHLMEIER M, ROELCKE U, BLÄUENSTEIN P, et al. Measurement of the extracellular space in brain tumors using 76Br-bromide and PET[J]. J Nucl Med, 2003, 44(8): 1210-1218.

周纯武.影像学在肿瘤诊治中的作用[J].癌症进展, 2006, 4(2): 110-110.

ZHOU C W. The role of imaging in the diagnosis and treatment of tumor[J]. Oncol Prog, 2006, 4(2): 110-110. DOI: 10.3969/j.issn.1672-1535. 2006.02.004.

李晗, 余晨.太赫兹波对肾癌组织的光谱检测[J].红外与激光工程, 2016, 001(5): 160-165.

LI H, YU C. Terahertz spectral detection in human renal tissue[J]. Infrared Laser Eng, 2016, 001(5): 160-165. DOI: 10.3788/IRLA201645.0525001.

WAHAIA F, KASALYNAS I, SELIUTA D, et al. Study of gastric cancer samples using terahertz techniques[J]. Second International Conference on Applications of Optics and Photonics, 2014. DOI:10.1117/12.2063463.

HOU D, LI X, CAI J, et al. Terahertz spectroscopic investigation of human gastric normal and tumor tissues[J]. Phys Med Biol, 2014, 59(18): 5423-5440. DOI:10.1088/0031-9155/59/18/5423.

QIAO W, YANG K, THOMA A, et al. Dielectric relaxation of HCl and NaCl solutions investigated by terahertz time-domain spectroscopy[J]. Journal of Infrared Millimeter and Terahertz Waves, 2012, 33(10): 1029-1038. DOI:10.1007/s10762-012-9920-z.

KNAB J R, CHEN J Y, HE Y, et al. Terahertz measurements of protein relaxational dynamics[J]. Proceedings of the IEEE, 2007, 95(8): 1605-1610. DOI:10.1109/JPROC.2007.898906.

ZHANG W, BROWN E R, RAHMAN M, et al. Observation of terahertz absorption signatures in microliter DNA solutions[J]. Applied Physics Letters, 2013, 102(2): 023701. DOI:10.1063/1.4775696.

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