Effect of acute traumatic stress on behavioral changes in mice

Yanxia Shao; Hang Sun; Xiaoping Zhou; Wei Sun

doi:10.16016/j.1000-5404.201701124

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Effect of acute traumatic stress on behavioral changes in mice

更新时间：2026-01-09

- Effect of acute traumatic stress on behavioral changes in mice
- Journal of Third Military Medical University Vol. 39, Issue 11, Pages: 1130-1136(2017)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201701124
  CLC：
- Received：20 January 2017，
  
  Published：15 June 2017
- 稿件说明：
移动端阅览
Yanxia Shao, Hang Sun, Xiaoping Zhou, et al. Effect of acute traumatic stress on behavioral changes in mice[J]. Journal of Third Military Medical University, 2017, 39(11): 1130-1136.
DOI：

Yanxia Shao, Hang Sun, Xiaoping Zhou, et al. Effect of acute traumatic stress on behavioral changes in mice[J]. Journal of Third Military Medical University, 2017, 39(11): 1130-1136. DOI： 10.16016/j.1000-5404.201701124.

摘要

Abstract

Objective

To determine the effect of acute traumatic stress on spontaneous behaviors

anxiety

learning and memory in mice.

Methods

Sixteen mice were randomly divided into experimental group (

=8) and control group (

=8). The mice of experimental group were given plantar shock while those of the control group were not. At the initial time after plantar shock (0 h)

and in 12 h and 7 d after the infliction

open field test and elevated plus maze test were used to observe the behavior changes

and water maze test was employed for the changes of learning and memory.

Results

① The standing time and the central activity time and distance showed significant differences between the 2 groups in 0 and 12 h after stress (

0.01)

with the experimental group less than control group

but significant difference was observed in the central activity time on the 7th day (

0.05). ② The number of enter open arms and residence time in open arms were significantly reduced in the mice from the experimental group than the control group at immediate and 12 h after stress (

0.05). ③ The escape latency was significantly prolonged in the experimental group than the control group on the 2nd and 3rd days (

0.05)

and the crossing platform times and target quadrant run ratio were also obviously larger than control group (

0.05).

Conclusion

Plantar electric shock can lead the decrease of spontaneous behavior in mice

decrease the exploratory behavior and learning ability

and increase the anxiety behavior

and to some extent

enhance spatial memory ability.

关键词

Keywords

references

Kassi E Pervanidou P Kaltsas G Metabolic syndrome: definitions and controversies BMC Med 2011 9 48 10.1186/1741-7015-9-48 Kassi E, Pervanidou P, Kaltsas G, et al .Metabolic syndrome: definitions and controversies[J ] .BMC Med, 2011, 9: 48.DOI:10.1186/1741-7015-9-48.

McEwen B S Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators Eur J Pharmacol 2008 583 2/3 174 185 10.1016/j.ejphar.2007.11.071 McEwen B S.Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators[J].Eur J Pharmacol, 2008, 583(2/3): 174-185.DOI:10.1016/j.ejphar.2007.11.071.

杜建政夏冰丽急性应激障碍(ASD)研究述评心理科学进展 2009 17 3 482 488 http://www.cnki.com.cn/Article/CJFDTOTAL-XLXD200903004.htm 杜建政, 夏冰丽.急性应激障碍(ASD)研究述评[J].心理科学进展, 2009, 17(3): 482-488.

Du J Z Xia B L A review of study on acute stress disorder Advances in Psychological Science 2009 17 3 482 488 http://www.cnki.com.cn/Article/CJFDTOTAL-XLXD200903004.htm Du J Z, Xia B L.A review of study on acute stress disorder[J].Advances in Psychological Science, 2009, 17(3): 482-488..

Wilson M A Grillo C A Fadel J R Stress as a one-armed bandit: Differential effects of stress paradigms on the morphology, neurochemistry and behavior in the rodent amygdala Neurobiol Stress 2015 1 195 208 10.1016/j.ynstr.2015.06.001 Wilson M A, Grillo C A, Fadel J R, et al .Stress as a one-armed bandit: Differential effects of stress paradigms on the morphology, neurochemistry and behavior in the rodent amygdala[J ] .Neurobiol Stress, 2015, 1:195-208.DOI:10.1016/j.ynstr.2015.06.001.

李欢欢林文娟李俊发急性生理应激对大鼠的行为及脑神经颗粒素磷酸化水平的影响心理学报 2007 39 4 648 655 http://www.cnki.com.cn/Article/CJFDTOTAL-XLXB200704011.htm 李欢欢, 林文娟, 李俊发.急性生理应激对大鼠的行为及脑神经颗粒素磷酸化水平的影响[J].心理学报, 2007, 39(4): 648-655.

Li H H Lin W J Li J F The effects of an acute physiological stressor on behaviors, protein levels and phosphorylation of neurogranin in rats Acta Psychologica Sinica 2007 39 4 648 655 http://www.cnki.com.cn/Article/CJFDTOTAL-XLXB200704011.htm Li H H, Lin W J, Li J F.The effects of an acute physiological stressor on behaviors, protein levels and phosphorylation of neurogranin in rats[J].Acta Psychologica Sinica, 2007, 39(4): 648-655.

王倩郑晓星杨蕴萍急性应激障碍能否预测创伤后应激障碍首都医科大学学报 2008 29 5 564 568 10.3969/j.issn.1006-7795.2008.05.006 王倩, 郑晓星, 杨蕴萍.急性应激障碍能否预测创伤后应激障碍[J].首都医科大学学报, 2008, 29(5): 564-568.DOI:10.3969/j.issn.1006-7795.2008.05.006.

Wang Q Zheng X X Yang Y P Can acute stress disorder predict posttraumatic stress disorder Journal of Capital Medical University 2008 29 5 564 568 10.3969/j.issn.1006-7795.2008.05.006 Wang Q, Zheng X X, Yang Y P.Can acute stress disorder predict posttraumatic stress disorder[J].Journal of Capital Medical University, 2008, 29(5): 564-568.DOI:10.3969/j.issn.1006-7795.2008.05.006.

Kingsbury T J Krueger B K Ca 2+ , CREB and krüppel: a novel KLF7-binding element conserved in mouse and human TRKB promoters is required for CREB-dependent transcription Mol Cell Neurosci 2007 35 3 447 455 10.1016/j.mcn.2007.04.004 Kingsbury T J, Krueger B K.Ca 2+ , CREB and krüppel: a novel KLF7-binding element conserved in mouse and human TRKB promoters is required for CREB-dependent transcription[J ] .Mol Cell Neurosci, 2007, 35(3): 447-455.DOI:10.1016/j.mcn.2007.04.004.

Stam R PTSD and stress sensitisation: A tale of brain and body.Part 2: Animal models Neurosci Biobehav Rev 2007 31 4 558 584 10.1016/j.neubiorev.2007.01.001 Stam R.PTSD and stress sensitisation: A tale of brain and body.Part 2: Animal models[J].Neurosci Biobehav Rev, 2007, 31(4):558-584.DOI:10.1016/j.neubiorev.2007.01.001.

Ekdahl C T Kokaia Z Lindvall O Brain inflammation and adult neurogenesis: the dual role of microglia Neuroscience 2009 158 3 1021 1029 10.1016/j.neuroscience.2008.06.052 Ekdahl C T, Kokaia Z, Lindvall O.Brain inflammation and adult neurogenesis: the dual role of microglia[J].Neuroscience, 2009, 158(3):1021-1029.DOI:10.1016/j.neuroscience.2008.06.052.

Deng W Aimone J B Gage F H New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 2010 11 5 339 350 10.1038/nrn2822 Deng W, Aimone J B, Gage F H.New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?[J].Nat Rev Neurosci, 2010, 11(5): 339-350.DOI:10.1038/nrn2822.

Hawley W Grissom E Keskitalo L Sexual motivation and anxiety-like behaviors of male rats after exposure to a trauma followed by situational reminders Physiol Behav 2011 102 2 181 187 10.1016/j.physbeh.2010.10.021 Hawley W, Grissom E, Keskitalo L, et al .Sexual motivation and anxiety-like behaviors of male rats after exposure to a trauma followed by situational reminders[J ] .Physiol Behav, 2011, 102(2): 181-187.DOI:10.1016/j.physbeh.2010.10.021.

Novaes L S Dos Santos N B Batalhote R F Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala Neuropharmacology 2017 113 Pt A 457 466 10.1016/j.neuropharm.2016.10.026 Novaes L S, Dos Santos N B, Batalhote R F, et al .Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala[J ] .Neuropharmacology, 2017, 113(Pt A): 457-466.DOI:10.1016/j.neuropharm.2016.10.026.

Ronzoni G Del Arco A Mora F Enhanced noradrenergic activity in the amygdala contributes to hyperarousal in an animal model of PTSD Psychoneuroendocrinology 2016 70 1 9 10.1016/j.psyneuen.2016.04.018 Ronzoni G, Del Arco A, Mora F, et al .Enhanced noradrenergic activity in the amygdala contributes to hyperarousal in an animal model of PTSD[J ] .Psychoneuroendocrinology, 2016, 70: 1-9.DOI:10.1016/j.psyneuen.2016.04.018.

Haghparast A Fatahi Z Alamdary S Z Changes in the levels of p-ERK, p-CREB, and c-fos in rat mesocorticolimbic dopaminergic system after morphine-induced conditioned place preference: the role of acute and subchronic stress Cell Mol Neurobiol 2014 34 2 277 288 10.1007/s10571-013-0011-z Haghparast A, Fatahi Z, Alamdary S Z, et al .Changes in the levels of p-ERK, p-CREB, and c-fos in rat mesocorticolimbic dopaminergic system after morphine-induced conditioned place preference: the role of acute and subchronic stress[J ] .Cell Mol Neurobiol, 2014, 34(2): 277-288.DOI:10.1007/s10571-013-0011-z.

Vila-Verde C Marinho A L Lisboa S F Nitric oxide in the prelimbic medial prefrontal cortex is involved in the anxiogenic-like effect induced by acute restraint stress in rats Neuroscience 2016 320 30 42 10.1016/j.neuroscience.2016.01.040 Vila-Verde C, Marinho A L, Lisboa S F, et al .Nitric oxide in the prelimbic medial prefrontal cortex is involved in the anxiogenic-like effect induced by acute restraint stress in rats[J ] .Neuroscience, 2016, 320: 30-42.DOI:10.1016/j.neuroscience.2016.01.040.

Clark R E Broadbent N J Squire L R The hippocampus and spatial memory: findings with a novel modification of the water maze J Neurosci 2007 27 25 6647 6654 10.1523/JNEUROSCI.0913-07.2007 Clark R E, Broadbent N J, Squire L R.The hippocampus and spatial memory: findings with a novel modification of the water maze[J].J Neurosci, 2007, 27(25): 6647-6654.DOI:10.1523/JNEUROSCI.0913-07.2007.

Morris R Developments of a water-maze procedure for studying spatial learning in the rat J Neurosci Methods 1984 11 1 47 60 10.1016/0165-0270(84)90007-4 Morris R.Developments of a water-maze procedure for studying spatial learning in the rat[J].J Neurosci Methods, 1984, 11(1): 47-60.DOI:10.1016/0165-0270(84)90007-4.

Wittner M Ríha P Transient hypobaric hypoxia improves spatial orientation in young rats Physiol Res 2005 54 3 335 340 https://www.researchgate.net/publication/7768538_Transient_hypobaric_hypoxia_improves_spatial_orientation_in_young_rats Wittner M, Ríha P.Transient hypobaric hypoxia improves spatial orientation in young rats[J].Physiol Res, 2005, 54(3): 335-340.

孙伊思 . 急性应激期大鼠学习敏感化的改变及其对PTSD样症状形成的预测作用 [D ] . 长沙 : 湖南师范大学 , 2012 . DOI: 10.7666/d.y2148260.Sun 孙伊思. 急性应激期大鼠学习敏感化的改变及其对PTSD样症状形成的预测作用[D]. 长沙: 湖南师范大学, 2012. DOI: 10.7666/d.y2148260.Sun

Y S . The changes in learning sensitive of acute stress in rats and predict the symptoms of PTSD [D ] . Chang Sha : Hunan Normal University , 2012 .DOI: 10.7666/d.y2148260. Y S.The changes in learning sensitive of acute stress in rats and predict the symptoms of PTSD[D].Chang Sha:Hunan Normal University, 2012.DOI: 10.7666/d.y2148260.

McFadden L M Paris J J Mitzelfelt M S Sex-dependent effects of chronic unpredictable stress in the water maze Physiol Behav 2011 102 3/4 266 275 10.1016/j.physbeh.2010.10.022 McFadden L M, Paris J J, Mitzelfelt M S, et al .Sex-dependent effects of chronic unpredictable stress in the water maze[J ] .Physiol Behav, 2011, 102(3/4): 266-275.DOI:10.1016/j.physbeh.2010.10.022.

Uysal N Sisman A R Dayi A Acute footshock-stress increases spatial learning memory and correlates to increased hippocampal BDNF and VEGF and cell numbers in adolescent male and female rats Neurosci Lett 2012 514 2 141 146 10.1016/j.neulet.2012.02.049. Uysal N, Sisman A R, Dayi A, et al .Acute footshock-stress increases spatial learning memory and correlates to increased hippocampal BDNF and VEGF and cell numbers in adolescent male and female rats[J ] .Neurosci Lett, 2012, 514(2):141-146.DOI:10.1016/j.neulet.2012.02.049.

肖婧姗李洋李娜 BDNF在急性应激所致小鼠空间学习记忆功能改变中的作用科技视界 2016 1 56 57 10.3969/j.issn.2095-2457.2016.01.044 肖婧姗, 李洋, 李娜, 等.BDNF在急性应激所致小鼠空间学习记忆功能改变中的作用[J].科技视界, 2016(1):56-57.DOI:10.3969/j.issn.2095-2457.2016.01.044.

Xiao J S Li Y Li N Role of BDNF in the Spatial Learning-memory Function of Mice Induced by Acute Stress Science & Technology Vision 2016 1 56 57 10.3969/j.issn.2095-2457.2016.01.044 Xiao J S, Li Y, Li N, et al .Role of BDNF in the Spatial Learning-memory Function of Mice Induced by Acute Stress [J ] .Science & Technology Vision, 2016(1):56-57.DOI:10.3969/j.issn.2095-2457.2016.01.044.

Cazakoff B N Johnson K J Howland J G Converging effects of acute stress on spatial and recognition memory in rodents: a review of recent behavioural and pharmacological findings Prog Neuropsychopharmacol Biol Psychiatry 2010 34 5 733 741 10.1016/j.pnpbp.2010.04.002 Cazakoff B N, Johnson K J, Howland J G.Converging effects of acute stress on spatial and recognition memory in rodents: a review of recent behavioural and pharmacological findings[J].Prog Neuropsychopharmacol Biol Psychiatry, 2010, 34(5): 733-741.DOI:10.1016/j.pnpbp.2010.04.002.

Philbert J Pichat P Beesk S Acute inescapable stress exposure induces long-term sleep disturbances and avoidance behavior: a mouse model of post-traumatic stress disorder (PTSD) Behav Brain Res 2011 221 1 149 154 10.1016/j.bbr.2011.02.039 Philbert J, Pichat P, Beesk S, et al .Acute inescapable stress exposure induces long-term sleep disturbances and avoidance behavior: a mouse model of post-traumatic stress disorder (PTSD)[J ] .Behav Brain Res, 2011, 221(1): 149-154.DOI:10.1016/j.bbr.2011.02.039.

Sijbrandij M Kleiboer A Bisson J I Corrections.Pharmacological prevention of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis Lancet Psychiatry 2015 2 7 584 10.1016/S2215-0366(15)00280-1 Sijbrandij M, Kleiboer A, Bisson J I, et al .Corrections.Pharmacological prevention of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis[J ] .Lancet Psychiatry, 2015, 2(7): 584.DOI:10.1016/S2215-0366(15)00280-1.

Hansen M Armour C Wittmann L Is there a common pathway to developing ASD and PTSD symptoms? J Anxiety Disord 2014 28 8 865 872 10.1016/j.janxdis.2014.09.019 Hansen M, Armour C, Wittmann L, et al .Is there a common pathway to developing ASD and PTSD symptoms?[J ] .J Anxiety Disord, 2014, 28(8): 865-872.DOI:10.1016/j.janxdis.2014.09.019.

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