Expression and clinical significance of pyruvate dehydrogenase kinase 4 in colon cancer

Yanrong Chen; Yuan Peng; Juanjuan Ou; Yue Zhang; Houjie Liang

doi:10.16016/j.1000-5404.201701045

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Expression and clinical significance of pyruvate dehydrogenase kinase 4 in colon cancer

更新时间：2026-01-09

- Expression and clinical significance of pyruvate dehydrogenase kinase 4 in colon cancer
- Journal of Third Military Medical University Vol. 39, Issue 11, Pages: 1144-1149(2017)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(81272364)
- DOI：10.16016/j.1000-5404.201701045
  CLC：
- Received：09 January 2017，
  
  Published：15 June 2017
- 稿件说明：
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Yanrong Chen, Yuan Peng, Juanjuan Ou, et al. Expression and clinical significance of pyruvate dehydrogenase kinase 4 in colon cancer[J]. Journal of Third Military Medical University, 2017, 39(11): 1144-1149.
DOI：

Yanrong Chen, Yuan Peng, Juanjuan Ou, et al. Expression and clinical significance of pyruvate dehydrogenase kinase 4 in colon cancer[J]. Journal of Third Military Medical University, 2017, 39(11): 1144-1149. DOI： 10.16016/j.1000-5404.201701045.

摘要

Abstract

Objective

To determine the expression of pyruvate dehydrogenase kinase 4 (PDK4) in colon cancer and adjacent mucosa tissues

and explore its clinical significance.

Methods

Tissue microarray and immunohistochemical staining were applied for the detection of PDK4 expression in the colon cancer samples from 172 colon cancer patients and adjacent mucosa tissues from 86 cases. The results and clinical pathological parameters were analyzed for statistical significance.

Results

The expression rate of PHD4 protein was significantly higher in the 172 colon cancer tissues than the 82 adjacent mucosa tissues(57.0%

26.7%

0.01). And its expression was closely associated with tumor differentiation

clinical stage

lymph node metastasis and prognosis (

0.05). The patients with higher expression level of PDK4 had shorter survival time than those with lower expression (

0.01). Among the patients at lower clinical stage

those with higher PDK4 expression level suggested a poorer prognosis (

0.01). But no such phenomena were seen in the patients at advanced stage of colon cancer.

Conclusion

The expression of PDK4 protein is higher in colon cancer tissues than adjacent mucosa tissues

and the protein may participate in the occurrence and development of colon cancer.

关键词

Keywords

references

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