Expression of drug-resistance gene CA916798 before and after chemotherapy for advanced lung cancer and its clinical significance

Hailing Duan; Lan Liang; Caixia Deng; Jialin Wang; Xiangdong Zhou

doi:10.16016/j.1000-5404.201701035

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Expression of drug-resistance gene CA916798 before and after chemotherapy for advanced lung cancer and its clinical significance

Clinical Medicine | 更新时间：2026-01-09

- Expression of drug-resistance gene CA916798 before and after chemotherapy for advanced lung cancer and its clinical significance
- Journal of Third Military Medical University Vol. 39, Issue 12, Pages: 1280-1285(2017)
- 作者机构：
  
  400038 重庆，第三军医大学西南医院呼吸内科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201701035
  CLC： R394.3;R730.53;R734.2
- Received：06 January 2017，
  
  Revised：2017-02-09，
  
  Published：30 June 2017
- 稿件说明：
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Hailing Duan, Lan Liang, Caixia Deng, et al. Expression of drug-resistance gene CA916798 before and after chemotherapy for advanced lung cancer and its clinical significance[J]. Journal of Third Military Medical University, 2017, 39(12): 1280-1285.
DOI：

Hailing Duan, Lan Liang, Caixia Deng, et al. Expression of drug-resistance gene CA916798 before and after chemotherapy for advanced lung cancer and its clinical significance[J]. Journal of Third Military Medical University, 2017, 39(12): 1280-1285. DOI： 10.16016/j.1000-5404.201701035.

摘要

目的

研究耐药基因CA916798在肺癌患者化疗前后肿瘤组织中的表达及意义。

方法

收集2016年3-12月在我院行纤支镜活检、病理确诊的肺癌患者17例，采用实时定量PCR(qRT-PCR)以及免疫组化的方法分析肺癌组织中CA916798基因mRNA及蛋白在化疗前后的表达。

结果

17例肺癌患者经过2个周期规范的前期化疗后，10例患者临床有效(病灶完全缓解或部分缓解)，总体有效率为58.82%。化疗无效组CA916798基因mRNA表达显著高于化疗有效组(

0.05)；前期化疗前，化疗无效组和化疗有效组CA916798蛋白表达阳性率差异无统计学意义；前期化疗后，化疗无效组CA916798蛋白表达阳性率显著高于化疗有效组(

0.05)。前期化疗后病灶稳定的患者中，再次化疗无效者，其CA916798基因表达在前期化疗后显著上调(

0.05)。

结论

肺癌患者肿瘤组织中CA916798基因的表达变化与化疗效果相关，可能成为预测肺癌化疗敏感性的新的参考指标。

Abstract

Objective

To detect the expression of drug-resistant gene CA916798 before and after chemotherapy in patients with advanced lung cancer and explore its clinical significance.

Methods

Between March and December 2016

17 patients with pathologically confirmed advanced lung cancer by fiberoptic bronchoscopy before and after chemotherapy in our department. The biopsy samples of the lung carcinoma tissue collected by bronchoscopy were examined with qRT-PCR and immunohistochemistry for CA916798 expression.

Results

All the 17 patients completed 2 cycles of chemotherapy

and 10 patients showed clinical responses (complete or partial remission) with an overall response rate of 58.82%. The mRNA expression of CA916798 in the tumor was significantly up-regulated in the non-responders than those responding to chemotherapy (

0.05). The positivity rate for CA916798 protein was comparable between the responders and non-responders before chemotherapy (

0.05)

but was significantly higher in the non-responders than in the responders after chemotherapy (

0.05). In the patients with stable disease after primary chemotherapy

the non-responders for secondary chemotherapy presented significantly un-regulated CA916798 expression level after first chemotherapy (

0.05).

Conclusion

The expression of CA916798 is correlated with the effect of chemotherapy and may change after chemotherapy. CA916798 expression level can be used as an indicator for predicting the effect of chemotherapy in patients with advanced lung cancer.

关键词

Keywords

references

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