Normal reference values for left ventricular peak systolic longitudinal strain and strain rate in healthy children at different ages: a preliminary analysis

Ying ZHONG; Dong WANG; Hui GAO; Li LYU; Xiaohua LIANG; Ke YANG; Zhaoxia WANG

doi:10.16016/j.1000-5404.201612177

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Normal reference values for left ventricular peak systolic longitudinal strain and strain rate in healthy children at different ages: a preliminary analysis

Clinical Medicine | 更新时间：2026-01-09

- Normal reference values for left ventricular peak systolic longitudinal strain and strain rate in healthy children at different ages: a preliminary analysis
- Journal of Third Military Medical University Vol. 39, Issue 17, Pages: 1750-1755(2017)
- 作者机构：
  
  1.400014 重庆, 重庆医科大学附属儿童医院超声科
  2.400014 重庆, 重庆医科大学附属儿童医院流行病学与生物信息学研究室
  3.400014 重庆, 重庆医科大学附属儿童医院儿科研究所
  4.400014 重庆, 重庆医科大学附属儿童医院儿童发育疾病研究教育部重点实验室, 儿童发育重大疾病国家国际科技合作基地, 儿科学重庆市重点实验室
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(81571688);the Special Project of Postdoctoral Scientific Research of Chongqing(Xm2014052);the Basic and Frontier Research Plan of Chongqing(CSTC2014jcyjA10013)
- DOI：10.16016/j.1000-5404.201612177
  CLC： R322.11;R339.31;R445.1
- Received：26 December 2016，
  
  Revised：2017-03-14，
  
  Published：15 September 2017
- 稿件说明：
移动端阅览
Ying ZHONG, Dong WANG, Hui GAO, et al. Normal reference values for left ventricular peak systolic longitudinal strain and strain rate in healthy children at different ages: a preliminary analysis[J]. Journal of Third Military Medical University, 2017, 39(17): 1750-1755.
DOI：

Ying ZHONG, Dong WANG, Hui GAO, et al. Normal reference values for left ventricular peak systolic longitudinal strain and strain rate in healthy children at different ages: a preliminary analysis[J]. Journal of Third Military Medical University, 2017, 39(17): 1750-1755. DOI： 10.16016/j.1000-5404.201612177.

摘要

目的

应用二维斑点追踪成像技术定量分析健康儿童左心室收缩期心肌纵向应变及应变率，并进行其不同年龄段正常参考值的初步分析。

方法

回顾性分析2015年9月至2016年11月来本院超声科体检的330例健康儿童的超声临床资料。按年龄分成7组，分为新生儿组(0~28 d)、婴儿组(＞28 d至＜1岁)、幼儿组(1~＜3岁)、学龄前期组(3~＜6岁)、学龄期组(6~＜9岁)、青春前期组(9~＜13岁)、青春期组(13~＜18岁)。采用斑点追踪软件分析左心室心尖3个长轴切面的动态图像，获取左心室收缩期心肌纵向应变及应变率值。

结果

① 6室壁节段间收缩期纵向应变及应变率的差异均有统计学意义(

0.05)，且纵向应变及应变率绝对值自基底段向心尖段呈逐渐增加趋势；② 18节段应变及应变率及整体应变在不同性别间差异均无统计学意义(

0.05)；③ 除后壁、下壁、后间隔基底段外，余各室壁节段纵向应变(longitudinal strain

LS)情况为|LS

新生儿组

|＜|LS

婴儿组

|＜|LS

幼儿、学龄前期、学龄期组

|＜|LS

青春前期、青春期组

且整体心肌纵向应变在年龄组间的趋势与其一致；④ 18节段应变与年龄呈正相关，以侧壁心尖段相关性最强(

=0.551，

0.01)；与心率均呈负相关，以侧壁中间段相关性最强(

=-0.517，

0.01)；整体心肌纵向应变与年龄呈正相关(

=0.665，

0.01)，与心率呈负相关(

=-0.625，

0.01)。⑤ 18节段应变率与年龄、心率的相关性，以及在各年龄

组间的差异存在不均一性。

结论

建立了不同年龄段健康儿童左心室收缩期心肌纵向应变及应变率的正常参考值，并发现其具有自身特征。

Abstract

Objective

To analyze the normal reference values of left ventricular longitudinal peak systolic strain (LS) and strain rate (LSr) by two-dimensional speckle tracking imaging (2D-STI) in healthy children at different ages.

Methods

Clinical ultrasound data of 330 healthy children who taking physical examination in our hospital from September 2015 to November 2016 were collected and retrospectively. They were divided into 7 groups according to their ages

that is

neonate group (0 to 28 days old)

infant group (28 days to 1 year old)

toddle group (1 to 3 years old)

pre-school group (3 to 6 years old)

school age group (6 to 9 years old)

pre-adolescence group (9 to 13 years old) and adolescence group (13 to 18 years old). 2D-STI was performed in the 3 apical projections of left ventricle (LV). The regional peak systolic longitudinal strain and strain rate of LV were measured.

Results

① Significant differences were found in the LS and LSr values from 6 segments of the same wall (

0.05)

and the LS and LSr values were gradually increased from basal segment to apical segment. ② There were no significant differences in the LS

LSr and global LS (GLS) values of 18 segments between sexes (

0.05). ③ Except the basal segments of posterior wall

inferior wall and posterior septum

LS value was gradually elevated with the increase of age (LS

neonate

infant

toddler

pre-school and school age

pre-adolescence and adolescence

)

so was GLS value. ④ LS in 18 segments had a positive correlation with age

and the value of apical segment in lateral wall was most remarkably correlated (

=0.551

0.01); Regional LS had a negati

ve correlation with heart rate

and that of middle segment in lateral wall was the most apparent (

=-0.625

0.01); GLS was positively influenced by age (

=0.665

0.01) and negatively affected by heart rate (

=-0.625

0.01). ⑤ The heterogeneities were found in the correlations of regional LSr with age and heart rate in segments and in the LSr among different age groups.

Conclusion

Normal reference values of LV peak LS and LSr are established for healthy children at different ages

and they possess their own characteristics.

关键词

Keywords

references

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