Correlation of apparent diffusion coefficient with common prognostic molecular biological indicators of non-small cell lung cancer
- Journal of Third Military Medical University Vol. 39, Issue 9, Pages: 913-918(2017)
- 作者机构：
- 作者简介：
- 基金信息：
DOI：10.16016/j.1000-5404.201612077
CLC：Received：12 December 2016，
Published：15 May 2017
- 稿件说明：
移动端阅览
Dan Zhang, Kang Chen, Zhihui Qiao, et al. Correlation of apparent diffusion coefficient with common prognostic molecular biological indicators of non-small cell lung cancer[J]. Journal of Third Military Medical University, 2017, 39(9): 913-918.
Dan Zhang, Kang Chen, Zhihui Qiao, et al. Correlation of apparent diffusion coefficient with common prognostic molecular biological indicators of non-small cell lung cancer[J]. Journal of Third Military Medical University, 2017, 39(9): 913-918. DOI： 10.16016/j.1000-5404.201612077.
摘要
Abstract
Objective
2
To analyze the correlation of apparent diffusion coefficient (ADC) with common prognostic molecular biological indicators of non-small cell lung cancer (NSCLC).
Methods
2
Thirty-nin
e patients with histopathologically conformed NSCLC admitted in the Department of Respiratory Diseases from April 2015 to September 2016 were recruited in this study. All the patients underwent diffusion weighted imaging (DWI)
ADCs were calculated based on DW images. Students'
t
test and single factor analysis of variance were applied to analyze the differences of ADCs in biological indicators
serum cancer embryo antigen (CEA)
positive rate of Ki67
thyroid transcription factor 1 (TTF-1)
and epidermal growth factor receptor (EGFR). Spearman rank correlation was used to analyze the correlations of the ADCs with above indicators.
Results
2
The ADCs in different indicators
such as CEA
Ki67
TTF-1 and EGFR were significantly different (
P
<
0.01). Negative correlations were found between ADCs and above biological indicators (CEA:
r
=-0.77
P
<
0.001; Ki67:
r
=-0.58
P
<
0.001; TTF-1:
r
=-0.47
P
=0.003; EGFR:
r
=-0.40
P
=0.012).
Conclusion
2
ADCs are negatively correlated with common prognostic indicators CEA
Ki67
TTF-1 and EGFR. Lower ADCs commonly suggest higher CEA and Ki67
which might predict positive TTF-1 and EGFR mutations.
关键词
Keywords
references
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