400042 重庆,第三军医大学新桥医院核医学科
Received:07 December 2016,
Revised:2017-02-27,
Published:30 May 2017
移动端阅览
Yuanmei Liu, Juan Meng, Qing Zhang. Value of 18F-FDG PET/CT in diagnosis of bone marrow infiltration in patients with non-Hodgkin's lymphoma[J]. Journal of Third Military Medical University, 2017, 39(10): 1001-1004.
Yuanmei Liu, Juan Meng, Qing Zhang. Value of 18F-FDG PET/CT in diagnosis of bone marrow infiltration in patients with non-Hodgkin's lymphoma[J]. Journal of Third Military Medical University, 2017, 39(10): 1001-1004. DOI: 10.16016/j.1000-5404.201612044.
目的
2
探讨
18
F-FDG PET/CT在非霍奇金淋巴瘤骨髓浸润评价中的应用价值。
方法
2
筛选2013年3月至2016年3月我院收治的150例非霍奇金淋巴瘤患者,回顾性分析
18
F-FDG PET/CT、MRI对骨髓浸润的诊断结果。
结果
2
18
F-FDG PET/CT对骨髓浸润的诊断敏感度、特异度、准确性分别为91.11%、97.14%、95.33%,明显高于MRI(
P
<
0.05);
18
F-FDG PET/CT对侵袭性非霍奇金淋巴瘤的骨髓浸润检出率高于惰性非霍奇金淋巴瘤(
P
<
0.05)。
结论
2
18
F-FDG PET/CT对非霍奇金淋巴瘤骨髓浸润具有较高的诊断价值,但对于惰性非霍奇金淋巴瘤骨髓浸润还需结合骨髓活检进行进一步的诊断。
Objective
2
To explore the value of
18
F-FDG PET/CT in the diagnosis of bone marrow infiltration in patients with non-Hodgkin's lymphoma.
Methods
2
A total of 150 patients with non-Hodgkin's lymphoma admitted in our hospital from March 2013 to March 2016 were analyzed retrospectively. The diagnosis results for bone marrow infiltration in these patients were compared between
18
F-FDG PET/CT and magnetic resonance imaging (MRI).
Results
2
The sensitivity
specificity and accuracy of
18
F-FDG PET/CT for diagnosing bone marrow infiltration was 91.11%
97.14%
and 95.33% respectively
significantly higher than those of MRI (
P
<
0.05).
18
F-FDG PET/CT showed a significantly higher detection rate of bone marrow infiltration in cases of invasive non-Hodgkin's lymphoma than in indolent non-Hodgkin's lymphoma (
P
<
0.05).
Conclusion
2
18
F-FDG PET/CT has a high value in diagnosing bone marrow infiltration in patients with non-Hodgkin lymphoma
but in cases of indolent non-Hodgkin's lymphoma
a definite diagnosis of bone marrow infiltration still relies on bone marrow biopsy.
李中泉, 谢丽璇, 张海捷, 等.骨淋巴瘤的 18 F-FDG PET/CT表现[J ] .临床军医杂志, 2015, 43(2): 189-191, 199. DOI:10.3969/j.issn.1671-3826.2015.02.26.
Li Z Q, Xie L X, Zhang H J, et al. 18 F-FDG PET/CT findings for bone lymphoma [J ] . Clinical Journal of Medical Officer, 2015, 43(2): 189-191199. DOI: 10.3969/ j.issn.1671-3826.2015.02.26.
李莹, 刘芯, 张还珠, 等.骨髓涂片、骨髓活检和 18 F-FDG PET-CT诊断非霍奇金淋巴瘤骨髓浸润的价值[J ] .广西医学, 2014, 36(7): 1003-1004. DOI: 10.11675/j.issn.0253-4304.2014.07.49.
Li Y, Liu X, Zhang H Z, et al. Bone marrow smear and bone marrow biopsy and 18 F-FDG value of PET-CT in diagnosis of non-Hodgkin lymphoma with bone marrow infiltration [J ] . Guangxi Medical Journal, 2014, 36 (7): 1003-1004. DOI: 10.11675/j.issn.0253-4304.2014.07.49.
岳进, 苏丽萍. 18 F-FDG PET/CT对淋巴瘤骨髓浸润的诊断及预后评估[J ] .国际肿瘤学杂志, 2016, 43(5): 395-397.DOI: 10.3760/cma.j.issn.1673-422X.2016.05.020.
Yue J, Su L P. Diagnosis and prognosis evaluation of 18 F-FDG pet/ct in bone marrow infiltration of lymphoma[J ] . Journal of Inter national Oncology, 2016, 43(5): 395-397. DOI: 10.3760/cma.j.issn.1673-422X.2016.05.020.
汤日杰, 桂思, 李建生, 等. 18 F-FDG PET/CT与大范围弥散磁共振成像评价非霍奇金淋巴瘤骨髓浸润的对比研究[J ] .中华血液学杂志, 2014, 35(3): 231-235. DOI:10.3760/cma.j.issn.0253-2727.2014.03.011.
Tang R J, Gui S, Li J S, et al. Comparative study of 18 F-FDG PET/CT and large scale diffusion magnetic resonance imaging in the evaluation of bone marrow infiltration in non Hondgkin'slymphoma [J ] . Chin J of Hematology, 2014, 35 (3): 231-235. DOI: 10.3760/cma.j.issn.0253-2727.2014.03.011.
白洁菲, 张迎强, 段明辉, 等. 18 F-FDG PET/CT三种评价方法在初治弥漫大B细胞淋巴瘤患者骨髓受累中的诊断价值[J ] .中华血液学杂志, 2015, 36(6): 489-492. DOI: 10.3760/cma.j.issn.0253-2727.2015.06.009.
Bai J F, Zhang Y Q, Duan M H, et al. Diagnostic value of three evaluation methods of 18 F-FDG PET/CT in detecting bone marrow infiltration in patients with newly diagnosed diffuse large B-cell lymphoma[J ] . Chinese Journal of Hematology, 2015, 36(6): 489-492. DOI: 10.3760/cma.j.issn.0253-2727.2015.06.009.
牛奔, 汪世存, 胡冰, 等. PET/CT标准摄取值和LDH与非霍奇金淋巴瘤临床病理特征的相关性研究[J].临床肿瘤学杂志, 2011, 16(2): 151-153. DOI: 10.3969/j.issn. 1009-0460.2011.02.013.
Niu B, Wang S C, Hu B, et al. Correlation of PET/CT and LDH standard uptake value of non Hodgkin's lymphoma with the clinico-pathological features of [J]. Journal of ClinicalOncology, 2011, 16 (2): 151-153. DOI: 10.3969/j.issn.1009-0460.2011.02.013.
张建华, 王荣福, 范岩, 等. 18 F-FDG PET/CT评价非霍奇金淋巴瘤骨髓浸润[J ] .中国介入影像与治疗学, 2012, 09(7): 539-543.
Zhang J H, Wang R F, Fan Y, et al. 18 F-FDG PET/CT for evaluation on bone marrow involvement in patients with non-Hodgkin lymphoma[J ] . Chinese Journal of Interventional Imaging and Therapy, 2012, 9(7): 539-543.
李佳, 郑柔, 国巍等. 18 F-FDG PET-CT在非霍奇金淋巴瘤结外病灶检测及精确分期中的应用[J ] .白血病·淋巴瘤, 2015, 24(9): 544-547. DOI: 10.3760/cma.j.issn.1009-9921.2015.09.008.
Li J, Zheng R, Guo W, et al. Application of 18 F-FDG PET-CT in detection and accurate staging of extranodal non-Hodgkin lymphoma[J ] . Journal of Leukemia & Lymphoma, 2015, 24(9): 544-547. DOI: 10.3760/cma.j.issn.1009-9921.2015.09.008.
刘婧慧, 李丽琴, 王争明, 等.淋巴瘤单发骨病变的 18 F-FDGPET/CT影像学分析[J ] .现代肿瘤医学, 2016, 24(9): 1452-1457. DOI: 10.3969/j.issn.1672-4992.2016.09.035.
Liu J H, Li L Q, Wang Z M, et al. Analysis of 18 F-FDGPET / CT imaging of single bone lesion of lymphoma [J ] .Modern Oncology, 2016, 24 (9): 1452-1457. DOI: 10.3969/ j.issn.1672-4992.2016.09.035.
党娜, 徐文贵, 宋秀宇, 等. 18 F-FDG PET-CT 显像在原发结外淋巴瘤诊断中的应用价值[J ] .中华血液学杂志, 2014, 35(1): 35-39. DOI: 10.3760/cma.j.issn.0253-2727.2014.01.009.
Dang N, Xu W G, Song X Y, et al. The value of 18 F-FDG PET-CT imaging in the diagnosis of primary extranodal lymphoma [J ] . Chinese Journal of Hematology, 2014, 35 (1): 35-39. DOI: 10.3760/cma.j.issn.0253-2727.2014. 01.009.
Chen L, Taida M S, Andres J, et al.The role of bone marrow biopsy and FDG-PET/CT in identifying bone marrow infiltration in the initial diagnosis of high grade non-Hodgkin B-cell lymphoma and Hodgkin lymphoma. Accuracy in a multicenter series of 372 patients[J]. American Journal of Hematology, 2015, 90(8): 686-690.
桂思, 汤日杰, 李建生, 等.非霍奇金淋巴瘤治疗前PET/CT中SUV的相关因素研究[J].中国煤炭工业医学杂志, 2014, 17(11): 1741-1745. DOI: 10.11723/mtgyyx1007-9564201411007.
Gui S, Tang R J, Li J S, et al. Correlation analysis of the SUV value in pre-therapy FDG-PET/CT in patients with non-Hodgkin lymphoma[J]. Chinese Journal of Coal Industry Medicine, 2014(11): 1741-1745. DOI: 10.11723/mtgyyx1007-9564201411007.
曹登敏, 林美福, 陈文新, 等.继发性骨淋巴瘤的 18 F-FDG PET/CT影像学表现[J ] .国际放射医学核医学杂志, 2016, 40(6): 403-407. DOI: 10.3760/cma.j.issn.1673-4114.2016.06.001.
Cao D M, Lin M F, Chen W X, et al. Analysis on 18 F-FDG PET/CT imaging characteristics in secondary bone lymphoma[J ] . International Journa l of Radiation Medicine and Nuclear Medicine, 2016, 40(6): 403-407. DOI: 10.3760/cma.j.issn.1673-4114.2016.06.001.
刘辉, 张春丽. PET-CT在淋巴瘤中的应用:第56届美国血液学会年会报道[J].白血病·淋巴瘤, 2015, 24(4): 197-199.DOI: 10.3760/cma.j.issn.1009-9921.2015.04.002.
Liu H, Zhang C L. Application of positron emission tomography-computed tomography in lymphoma: Reports from the 56th american society of hematology annual meeting[J]. Journal of Leukemia&Lymphoma, 2015, 24(4): 197-199. DOI: 10.3760/cma.j.issn.1009-9921.2015.04.002.
吴媛, 苏丽萍, 杨晓棠, 等.正电子发射计算机体层摄影和磁共振扩散加权成像评价淋巴瘤骨髓浸润的初步研究[J].中华肿瘤杂志, 2016, 38(11): 853-860. DOI: 10.3760/cma.j.issn.0253-3766.2016.11.011.
Wu Y, Su L P, Yang X T, et al. Preliminary evaluation of pet-ct and dwi for the detection of lymphoma bone marrow infiltration[J]. Chinese Journal of Oncology, 2016, 38(11): 853-860. DOI: 10.3760/cma.j.issn.0253-3766.2016.11.011.
Akhtar S, Al-Sugair A S, Abouzied M, et al. Pre-transplant (18) F-fluorodeoxyglucose positron emission tomography-based survival model in patients with aggressive lymphoma undergoing high-dose chemotherapy and autologous SCT[J]. Bone Marrow Transplant, 2013, 48(4): 551-556. DOI: 10.1038/bmt.2012.168.
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