Effect of extracorporeal shock wave therapy combined with tamsulosin on category ⅢB chronic prostatitis/chronic pelvic pain syndrome and the mechanis

Bin LIN; Xingyan ZHANG; Liang WANG

doi:10.16016/j.1000-5404.201611236

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Effect of extracorporeal shock wave therapy combined with tamsulosin on category ⅢB chronic prostatitis/chronic pelvic pain syndrome and the mechanis

Clinical Medicine | 更新时间：2026-01-09

- Effect of extracorporeal shock wave therapy combined with tamsulosin on category ⅢB chronic prostatitis/chronic pelvic pain syndrome and the mechanis
- Journal of Third Military Medical University Vol. 39, Issue 14, Pages: 1498-1502(2017)
- 作者机构：
  
  1.610400 成都，金堂县第一人民医院(四川大学华西医院金堂医院)泌尿外科
  2.400037 重庆，重庆市肿瘤医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.201611236
  CLC： R392.32; R454.4; R697.33
- Received：28 November 2016，
  
  Revised：2016-12-27，
  
  Published：30 July 2017
- 稿件说明：
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Bin LIN, Xingyan ZHANG, Liang WANG. Effect of extracorporeal shock wave therapy combined with tamsulosin on category ⅢB chronic prostatitis/chronic pelvic pain syndrome and the mechanis[J]. Journal of Third Military Medical University, 2017, 39(14): 1498-1502.
DOI：

Bin LIN, Xingyan ZHANG, Liang WANG. Effect of extracorporeal shock wave therapy combined with tamsulosin on category ⅢB chronic prostatitis/chronic pelvic pain syndrome and the mechanis[J]. Journal of Third Military Medical University, 2017, 39(14): 1498-1502. DOI： 10.16016/j.1000-5404.201611236.

摘要

目的

探讨体外冲击波治疗(extracorporeal shock wave therapy，ESWT)对ⅢB型慢性前列腺炎(CP)/慢性盆腔疼痛综合征(CPPS)患者免疫反应的影响，并观察其疗效。

方法

收集2014年1月至2016年9月于我院就诊的120例CP/CPPS患者，采用随机数字表法分为试验组与对照组，各60例。对照组给予坦索罗辛治疗，试验组予ESWT+坦索罗辛治疗，两组均治疗4周。治疗后收集两组患者慢性前列腺炎症状评分(NIH-CPSI)，国际前列腺症状评分(IPSS)，前列腺液中TNF-α、IL-6、卵磷脂小体及外周血中CD3

、CD4

、CD8

、CD4

CD25

、TGF-β1、CD4

CD25

Foxp3

的表达变化。

结果

治疗4周后，与对照组相比，试验组总体有效率明显提高(63.3%

93.3%，

0.05)；NIH-CPSI评分(13.12± 1.71

23.16±1.33) 和IPSS评分(8.23±2.28

13.14±2.69) 明显降低。在炎症和免疫影响方面，与对照组相比，试验组前列腺液中卵磷脂小体明显升高，炎性因子TNF-α、IL-1β水平明显降低；外周血中CD3

、CD4

、CD8

、CD4

CD25

、TGF-β1、CD4

CD25

Foxp3

表达均明显提高。

结论

ESWT治疗ⅢB型CP/CPPS安全有效，其可能的作用机制与提高患者的免疫功能、降低前列腺局部炎症应答有关。

Abstract

Objective

To investigate the effect of extracorporeal shock wave therapy (ESWT) combined with tamsulosin on category ⅢB chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and explore the possible mechanisms.

Methods

A total of 120 patients with category ⅢB CP/CPPS were randomized into ESWT group and control group (

=60) to receive treatments with ESWT plus tams

ulosin and tamsulosin alone

respectively. After 4 weeks of treatment

the improvements of clinical symptoms (NIH-CPSI and IPSS score)

levels of tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) and lecithin bodies in the prostatic fluid

and levels of CD3

CD4

CD8

CD4

CD25

CD4

CD25

Foxp3

cells and transforming growth factor (TGF)-β1 in the peripheral blood were determined.

Results

After 4 weeks of treatment

the patients in ESWT group showed a significantly higher overall response rate than those in the control group (93.3%

63.3%

0.05) with and significantly decreased scores of NIH-CPSI (13.12±1.71

23.16±1.33) and IPSS (8.23±2.28

13.14±2.69). Compared with those in the control group

the content of lecithin body was significantly increased and the levels of inflammatory factors TNF-α and IL-1 were significantly decreased in ESWT group; the contents of CD3

CD4

CD8

CD4

CD25

CD4

CD25

Foxp3

cells and TGF-β1 level in peripheral blood were significantly increased in ESWT group.

Conclusion

ESWT combined with tamsulosin is safe and effective for treatment of category ⅢB CP/CPPS possibly by improving the immune function and reducing the local inflammatory response in the prostate.

关键词

Keywords

references

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