Expression and clinical significance of B cell translocation gene 2 in primary hepatocellular carcinoma

Yunfei Ye; He Xiao; Jia Luo; Guocheng Pi; Ge Wang

doi:10.16016/j.1000-5404.201611153

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Expression and clinical significance of B cell translocation gene 2 in primary hepatocellular carcinoma

更新时间：2026-01-09

- Expression and clinical significance of B cell translocation gene 2 in primary hepatocellular carcinoma
- Journal of Third Military Medical University Vol. 39, Issue 7, Pages: 685-690(2017)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(81572959)
- DOI：10.16016/j.1000-5404.201611153
  CLC：
- Received：17 November 2016，
  
  Published：2017-07
- 稿件说明：
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Yunfei Ye, He Xiao, Jia Luo, et al. Expression and clinical significance of B cell translocation gene 2 in primary hepatocellular carcinoma[J]. Journal of Third Military Medical University, 2017, 39(7): 685-690.
DOI：

Yunfei Ye, He Xiao, Jia Luo, et al. Expression and clinical significance of B cell translocation gene 2 in primary hepatocellular carcinoma[J]. Journal of Third Military Medical University, 2017, 39(7): 685-690. DOI： 10.16016/j.1000-5404.201611153.

摘要

Abstract

Objective

To investigate the expression of B cell translocation gene 2 (BTG2) in the patients with hepatocellular carcinoma (HCC)

and its relationship with postoperative prognosis.

Methods

One hundred and twenty-five patients with hepatocellular carcinoma confirmed pathologically and undergoing surgical treatment in our hospital from January 2012 to December 2014 were enrolled in this study. Among them

101 cases had complete follow-up data. According to the protein expression of BTG2 evaluated by immunohistochemical assay

the subjects were categorized to 3 groups

that is

high (+ +/+ + +)

low (+) and negative expression (-) groups. The correlation of BTG2 expression level with clinical pathological factors and overall survival were analyzed. Twelve pairs of tumor and para-carcinoma tissues were employed to detect the mRNA level of BTG2 by RT-PCR.

Results

In the obtained tumor tissues from 125 case

there 6

13 and 103 cases respectively with high

low and negative expression of BTG2

and the positive rates were 22

41 respectively for the corresponding para-carcinoma tissues. The expression was significantly different between the tumor and para-carcinoma tissues (

Chi

square=28.102

0.001). The RT-PCR results showed that there were 8/12 pairs of tumor and para-carcinoma tissues with BTG2 expression level lower in the tumor tissue than the para-carcinoma tissue. Occurrence of tumor thrombus was significantly associated with BTG2 expression (

Chi

square=8.305

=0.013)

and the low BTG2 expression group had the highest incidences of tumor thrombus. The median overall survival (mOS) was 36 months in the low BTG2 expression group (95%

: 8.436~63.564)

while there was no mOS reached in the high expression and negative groups (Log-Rank

Chi

square=4.512

=0.105). However

the OS was significantly longer in the high than low expression groups (

Chi

square=4.266

=0.039). And there was no significant difference between the high and negative groups (

Chi

square=2.729

=0.099)

or between the low and negative groups (

Chi

square=1.400

=0.237). Stepwise Cox regression analysis showed that differentiation grade

hepatocirrhosis

tumor thrombus and metastasis were independent prognostic factors for OS in the HCC patients.

Conclusion

BTG2 protein is lowly expressed in the HCC tissues

and its high expression indicates better prognosis. It can be used as a potential prognostic factor for HCC.

关键词

Keywords

references

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